STAT3 and NF-κB Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 • 2,856 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

2003 • 1,828 citations

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

2003 • 1,652 citations

A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

2002 • 1,238 citations

Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway

2005 • 1,010 citations

IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages.

1998 • 954 citations

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades

2001 • 930 citations

Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17

2005 • 895 citations

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

2005 • 844 citations

IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages

1998 • 810 citations

Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

2000 • 713 citations

Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4

2004 • 547 citations

IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

2003 • 488 citations

The molecular basis of T helper 1 and T helper 2 cell differentiation

2000 • 400 citations

Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-α and Granulocyte Colony-Stimulating Factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis

2005 • 388 citations

The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.

2005 • 378 citations

IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways

2004 • 372 citations

Induction of Experimental Autoimmune Encephalomyelitis in IL-12 Receptor-β2-Deficient Mice: IL-12 Responsiveness Is Not Required in the Pathogenesis of Inflammatory Demyelination in the Central Nervous System

2003 • 304 citations

Blocking of Interleukin-17 during Reactivation of Experimental Arthritis Prevents Joint Inflammation and Bone Erosion by Decreasing RANKL and Interleukin-1

2005 • 299 citations

Interleukin‐17 in rheumatoid arthritis: If T cells were to contribute to inflammation and destruction through synergy

2003 • 260 citations

Interleukin-17: a mediator of inflammatory responses

2004 • 252 citations

IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis

2003 • 166 citations

IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis

2003 • 164 citations

IL‐23 up‐regulates IL‐10 and induces IL‐17 synthesis by polyclonally activated naive T cells in human

2005 • 143 citations

IL-12– and IL-23–induced T helper cell subsets

2005 • 139 citations

Prevention of Hepatic Apoptosis and Embryonic Lethality in RelA/TNFR-1 Double Knockout Mice

2000 • 132 citations

TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice

2004 • 122 citations

Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.

2004 • 113 citations

CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3–kinase/AKT/NF-κB signaling

2003 • 112 citations

Granulocyte-Macrophage Colony-stimulating Factor-activated Signaling Pathways in Human Neutrophils

1999 • 87 citations

Effector function of type II collagen–stimulated T cells from rheumatoid arthritis patients: Cross‐talk between T cells and synovial fibroblasts

2004 • 85 citations

IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells

2003 • 83 citations

The Pro-atherogenic Cytokine Interleukin-18 Induces CXCL16 Expression in Rat Aortic Smooth Muscle Cells via MyD88, Interleukin-1 Receptor-associated Kinase, Tumor Necrosis Factor Receptor-associated Factor 6, c-Src, Phosphatidylinositol 3-Kinase, Akt, c-Jun N-terminal Kinase, and Activator Protein-1 Signaling

2005 • 83 citations

Interleukin‐17: the missing link between T‐cell accumulation and effector cell actions in rheumatoid arthritis?

2004 • 83 citations

The role of IL-17 and family members in the pathogenesis of arthritis.

2003 • 73 citations

IL-23 Induces Stronger Sustained CTL and Th1 Immune Responses Than IL-12 in Hepatitis C Virus Envelope Protein 2 DNA Immunization

2004 • 72 citations

Role of the IL-12/IL-23 System in the Regulation of T-Cell Responses in Central Nervous System Inflammatory Demyelination;

2004 • 67 citations

Cytokines in the induction and resolution of experimental autoimmune encephalomyelitis

2005 • 66 citations

Genetic variations in the interleukin-12/interleukin-23 receptor (β1) chain, and implications for IL-12 and IL-23 receptor structure and function

2003 • 52 citations

The IL-12Rβ2 gene functions as a tumor suppressor in human B cell malignancies

2004 • 52 citations

The IL-12Rβ2 gene functions as a tumor suppressor in human B cell malignancies

2004 • 52 citations

NF-κB Couples Protein Kinase B/Akt Signaling to Distinct Survival Pathways and the Regulation of Lymphocyte Homeostasis In Vivo

2005 • 48 citations

Activation of Nuclear Factor of Activated T Cells-(NFAT) and Activating Protein 1 (AP-1) by Oncogenic 70Z Cbl Requires an Intact Phosphotyrosine Binding Domain but Not Crk(L) or p85 Phosphatidylinositol 3-Kinase Association

1999 • 33 citations

IL-23 and IL-27: new members of the growing family of IL-12-related cytokines with important implications for therapeutics

2003 • 31 citations

Interleukin-1β and tumor necrosis factor-α upregulate interleukin-23 subunit p19 gene expression in human colonic subepithelial myofibroblasts

2005 • 30 citations

Phosphorylation of the Grb2- and Phosphatidylinositol 3-Kinase p85–binding p36/38 by Syk in Lck-Negative T Cells

1998 • 21 citations

Enhancement of Interleukin-12 Gene-Based Tumor Immunotherapy by the Reduced Secretion of p40 Subunit and the Combination with Farnesyltransferase Inhibitor

2005 • 21 citations

Fas Ligand Induces Cell-Autonomous IL-23 Production in Dendritic Cells, a Mechanism for Fas Ligand-Induced IL-17 Production

2005 • 21 citations

T cell-to-T cell clustering enhances NF-κB activity by a PI3K signal mediated by Cbl-b and Rho

2005 • 9 citations