IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma

Statistical Methods in Cancer Research

1980 • 6,825 citations

Statistical methods in cancer research. Volume I - The analysis of case-control studies.

1980 • 4,991 citations

Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men

2000 • 2,394 citations

The analysis of case-control studies

1980 • 2,363 citations

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

1998 • 2,261 citations

Statistical methods in cancer research. Vol. 1. The analysis of case-control studies

1983 • 1,720 citations

Comprehensive human genome amplification using multiple displacement amplification

2002 • 1,429 citations

Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty

2000 • 1,245 citations

PATHOGENESIS OF LIPOID NEPHROSIS: A DISORDER OF T-CELL FUNCTION

1974 • 1,152 citations

[Hodgkin's disease].

1988 • 829 citations

Cooperative Influence of Genetic Polymorphisms on Interleukin 6 Transcriptional Regulation

2000 • 802 citations

A revised estimate of twin concordance in systemic lupus erythematosus

1992 • 765 citations

The pathology and nomenclature of Hodgkin's disease.

1972 • 762 citations

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

1996 • 749 citations

Epidemiology of Hodgkin's Disease

1973 • 492 citations

The paradigm of IL-6: from basic science to medicine.

2002 • 476 citations

Hodgkin's Disease and Epstein-Barr Virus

1989 • 447 citations

Interleukin-6 Gene −174G>C and −572G>C Promoter Polymorphisms Are Strong Predictors of Plasma Interleukin-6 Levels After Coronary Artery Bypass Surgery

2001 • 408 citations

Altered cytokine production in the elderly

1998 • 379 citations

ASSOCIATION OF CYTOKINE POLYMORPHIC INHERITANCE AND IN VITRO CYTOKINE PRODUCTION IN ANTI-CD3/CD28-STIMULATED PERIPHERAL BLOOD LYMPHOCYTES1

2001 • 345 citations

Concordance for Hodgkin's Disease in Identical Twins Suggesting Genetic Susceptibility to the Young-Adult Form of the Disease

1995 • 335 citations

THE ORIGIN OF HODGKIN AND REED/STERNBERG CELLS IN HODGKIN'S DISEASE

1998 • 314 citations

Hodgkin's lymphoma

2003 • 233 citations

1 The epidemiology of Hodgkin's disease

1996 • 215 citations

Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjogren's syndrome and correlate with the clinical manifestations of the disease

2001 • 208 citations

Coagulation and fibrinolysis abnormalities in obesity

2002 • 204 citations

Validation of a telephone zygosity questionnaire in twins of known zygosity.

1998 • 193 citations

Hodgkin's Disease in Siblings

1977 • 184 citations

Molecular and cellular biology of interleukin-6 and its receptor

1996 • 183 citations

Epidemiology of Hodgkin's disease in the young

1977 • 180 citations

Glomerular lesions in lymphomas and leukemias

1986 • 164 citations

An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in men infected with human immunodeficiency virus

2000 • 145 citations

Risk of Hodgkin's Disease and Other Cancers After Infectious Mononucleosis

2000 • 144 citations

Epidemiology of EBV and Hodgkin's lymphoma

1996 • 142 citations

Risk factors for Hodgkin’s disease by Epstein-Barr virus (EBV) status: prior infection by EBV and other agents

2000 • 136 citations

The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults.

2001 • 135 citations

Immune escape mechanisms in Hodgkin’s disease

1998 • 111 citations

Application of the Missing-Indicator Method in Matched Case-Control Studies with Incomplete Data

1999 • 109 citations

A Polymorphism in the Promoter Region of the Gene for Interleukin-6 Is Associated with Susceptibility to Type 1 Diabetes Mellitus

2000 • 105 citations

Lymphotoxin, tumour necrosis factor and interleukin‐6 gene transcripts are present in Hodgkin and Reed‐Sternberg cells of most Hodgkin's disease cases

1993 • 105 citations

Social class and age at diagnosis of Hodgkin's disease: new epidemiologic evidence for the "two-disease hypothesis".

1982 • 98 citations

Localization of predisposition to Hodgkin disease in the HLA class II region.

1994 • 90 citations

HLA and Susceptibility to Hodgkin's Disease

1983 • 90 citations

Hodgkin's disease in patients with previous infectious mononucleosis

1979 • 84 citations

Clinical Correlates of Elevated Serum Levels of Interleukin-6 in Patients with Untreated Hodgkin's Disease

1997 • 83 citations

Risk patterns of Hodgkin's disease in Los Angeles vary by cell type.

1992 • 75 citations

Interleukin 6 expression by Hodgkin/Reed–Sternberg cells is associated with the presence of ‘B’ symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease

2002 • 73 citations

3 Immunology of Hodgkin's disease

1996 • 69 citations

Serum cytokine levels correlate with clinical parameters in Hodgkin’s disease

1995 • 61 citations

Cross-sectional study on cytokine polymorphisms, cytokine production after T-cell stimulation and clinical parameters in a random sample of a German population

2001 • 58 citations

HLA-DR, HLA-DQ, and TAP genes in familial Hodgkin disease

2002 • 55 citations

Modulation of interleukin-6 expression in Hodgkin and Reed-Sternberg cells by Epstein-Barr virus

1997 • 51 citations

Interleukin-6, but not interleukin-4, is expressed by Reed-Sternberg cells in Hodgkin's disease with or without histologic features of Castleman's disease.

1992 • 47 citations

Soluble Cytokine Levels Correlate with the Activity and Clinical Stage of Hodgkin's Disease at Diagnosis

2000 • 33 citations

FAMILIAL HODGKIN'S DISEASE

1972 • 31 citations

IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2

2002 • 31 citations

Familial Hodgkin's disease a clinical and laboratory investigation

1987 • 30 citations

Representativeness of a roster of volunteer North American twins with chronic disease

2000 • 29 citations

Serum concentrations of cytokines in patients with Hodgkin's disease

1994 • 24 citations

Increased levels of circulating cytokines in patients with untreated Hodgkin's disease.

1992 • 24 citations

Development and Representativeness of a Large Population-Based Cohort of Native Californian Twins

2001 • 21 citations

Hodgkin and Reed-Sternberg Cells Express Interleukin 6 and Interleukin 6 Receptors

1992 • 19 citations

bcl-2 Oncogene Protein Is Preferentially Expressed in Reed-Sternberg Cells in Hodgkin’s Disease of the Nodular Sclerosis Subtype

1994 • 12 citations

Analysing the effects of anaemia on local recurrence of head and neck cancer when covariate values are missing

2000 • 5 citations