IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 • 2,856 citations

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

2003 • 1,828 citations

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

2003 • 1,652 citations

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

2003 • 1,280 citations

EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON

1987 • 1,062 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

1999 • 723 citations

Treatment with a neutralizing anti‐murine interleukin‐17 antibody after the onset of collagen‐induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

2004 • 698 citations

Development of anti-TNF therapy for rheumatoid arthritis

2002 • 673 citations

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.

1996 • 642 citations

Microbial Lipopeptides Induce the Production of IL-17 in Th Cells

2000 • 589 citations

IL-17: prototype member of an emerging cytokine family

2002 • 589 citations

High Levels of IL-17 in Rheumatoid Arthritis Patients: IL-15 Triggers In Vitro IL-17 Production Via Cyclosporin A-Sensitive Mechanism

2000 • 588 citations

Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes

1998 • 565 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

2003 • 488 citations

Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response toKlebsiella pneumoniaeInfection

2003 • 452 citations

IL-17 Is Produced by Some Proinflammatory Th1/Th0 Cells But Not by Th2 Cells

1999 • 415 citations

The molecular basis of T helper 1 and T helper 2 cell differentiation

2000 • 400 citations

IL-12p35-Deficient Mice Are Susceptible to Experimental Autoimmune Encephalomyelitis: Evidence for Redundancy in the IL-12 System in the Induction of Central Nervous System Autoimmune Demyelination

2002 • 395 citations

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

2002 • 382 citations

Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

1991 • 362 citations

Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12

2002 • 332 citations

The role of gamma interferon in antimicrobial immunity

2001 • 328 citations

Induction of Experimental Autoimmune Encephalomyelitis in IL-12 Receptor-β2-Deficient Mice: IL-12 Responsiveness Is Not Required in the Pathogenesis of Inflammatory Demyelination in the Central Nervous System

2003 • 304 citations

Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivo

2002 • 289 citations

Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis.

1995 • 283 citations

Interferon-γ-Induced Oligodendrocyte Cell Death: Implications for the Pathogenesis of Multiple Sclerosis

1995 • 249 citations

A Protective and Agonistic Function of IL-12p40 in Mycobacterial Infection

2001 • 226 citations

Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 in the VLA family of heterodimers

1988 • 218 citations

Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice

2004 • 209 citations

IL-12 unmasks latent autoimmune disease in resistant mice.

1996 • 182 citations

IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-12

2004 • 167 citations

Inducible costimulator is essential for collagen-induced arthritis

2003 • 118 citations

Interferon-γ in Progression to Chronic Demyelination and Neurological Deficit Following Acute EAE

1998 • 100 citations

The IL-12Rβ2 gene functions as a tumor suppressor in human B cell malignancies

2004 • 52 citations

The IL-12Rβ2 gene functions as a tumor suppressor in human B cell malignancies

2004 • 52 citations