Regulation of Tumor Growth and Metastasis by Interleukin-10: The Melanoma Experience

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Angiogenic Factors

1987 • 3,702 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Interleukin-10

1993 • 1,820 citations

The role of angiogenesis in tumor growth.

1992 • 1,267 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

Macrophages and angiogenesis

1994 • 1,123 citations

The origin and function of tumor-associated macrophages

1992 • 1,081 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Biological properties of interleukin 10

1992 • 656 citations

Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1

1990 • 539 citations

IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.

1992 • 417 citations

A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses.

1995 • 415 citations

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1990 • 347 citations

Production of IL‐10 by melanoma cells: Examination of its role in immunosuppression mediated by melanoma

1994 • 248 citations

Interleukin‐10 production by human carcinoma cell lines and its relationship to interleukin‐6 expression

1993 • 245 citations

Consequences of angiogenesis for tumor progression, metastasis and cancer therapy

1995 • 243 citations

Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes

1994 • 238 citations

Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.

1992 • 235 citations

Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism.

1996 • 227 citations

Differential effects of IL-4 and IL-10 on IL-2-induced IFN-γ synthesis and lymphokine-activated killer activity

1992 • 210 citations

Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors.

1995 • 190 citations

Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.

1994 • 187 citations

Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory.

1995 • 180 citations

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.

1994 • 167 citations

Antimetastatic and Antitumor Activities of Interleukin 10 in a Murine Model of Breast Cancer

1996 • 157 citations

Pharmacokinetics and immunomodulatory properties of intravenously administered recombinant human interleukin-10 in healthy volunteers

1996 • 153 citations

Interleukin 10 suppresses tumor growth and metastasis of human melanoma cells: potential inhibition of angiogenesis.

1996 • 151 citations

Expression of interleukin 10 in human melanoma

1994 • 147 citations

Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.

1993 • 140 citations

Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma

1995 • 138 citations

Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis: IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2/MMP-9 secretion.

1999 • 130 citations

Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers

1992 • 124 citations

Interleukin 10 production by human melanoma.

1996 • 113 citations

Interleukin-10 production in malignant melanoma: Preferential detection of IL-10-secreting tumor cells in metastatic lesions

1996 • 105 citations

The short unique region of the B95-8 Epstein-Barr virus genome

1985 • 90 citations

Interleukin 10

1991 • 87 citations

Loss of Tumorigenicity and Increased Immunogenicity Induced by Interleukin-10 Gene Transfer in B16 Melanoma Cells

1996 • 83 citations

Differential modulation by interferon γ of the sensitivity of human melanoma cells to cytolytic T cell clones that recognize differentiation or progression antigens

1996 • 15 citations

Deleted Work

1955 • 0 citations