Immune cell migration in inflammation: present and future therapeutic targets

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Immunobiology of Dendritic Cells

2000 • 6,653 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

2003 • 3,265 citations

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

1998 • 1,943 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

2002 • 1,734 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

T-Cell Function and Migration — Two Sides of the Same Coin

2000 • 1,437 citations

A Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis

2003 • 1,228 citations

C<scp>hemokines in</scp>I<scp>nnate and</scp>A<scp>daptive</scp>H<scp>ost</scp>D<scp>efense</scp>: Basic Chemokinese Grammar for Immune Cells

2004 • 1,199 citations

Extracellular matrix remodelling: the role of matrix metalloproteinases

2003 • 1,061 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

2002 • 989 citations

Essential involvement of interleukin-8 (IL-8) in acute inflammation

1994 • 982 citations

CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANS

2004 • 840 citations

Natalizumab for Active Crohn's Disease

2003 • 815 citations

Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response

2003 • 798 citations

Ligands for L-Selectin: Homing, Inflammation, and Beyond

2003 • 762 citations

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

1997 • 735 citations

Treatment of Ulcerative Colitis with a Humanized Antibody to the α₄β₇Integrin

2005 • 692 citations

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

2005 • 681 citations

Macromolecular organization of basement membranes

1996 • 661 citations

A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them

2004 • 625 citations

Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment

2000 • 620 citations

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes

2002 • 581 citations

Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes

2003 • 563 citations

RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium

2001 • 561 citations

Integrin cytoplasmic domain-binding proteins

2000 • 560 citations

Intracellular signalling controlling integrin activation in lymphocytes

2005 • 547 citations

Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8

1993 • 529 citations

Plasma-cell homing

2003 • 514 citations

Migratory Properties of Naive, Effector, and Memory Cd8+ T Cells

2001 • 514 citations

CC Chemokine Receptor (CCR)4 and the CCR10 Ligand Cutaneous T Cell–attracting Chemokine (CTACK) in Lymphocyte Trafficking to Inflamed Skin

2001 • 502 citations

Integrin avidity regulation: are changes in affinity and conformation underemphasized?

2003 • 491 citations

Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics

2005 • 489 citations

Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood–Brain Barrier in Experimental Autoimmune Encephalomyelitis

2001 • 487 citations

CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue

2000 • 485 citations

Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses

2005 • 462 citations

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues

2005 • 458 citations

Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases

2003 • 419 citations

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

2000 • 419 citations

Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment

2003 • 416 citations

Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

1998 • 415 citations

Selectins: lectins that initiate cell adhesion under flow

2002 • 409 citations

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

2005 • 405 citations

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness

2002 • 385 citations

An Antagonist of Monocyte Chemoattractant Protein 1 (MCP-1) Inhibits Arthritis in the MRL-lpr Mouse Model

1997 • 382 citations

Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor.

1997 • 372 citations

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

2003 • 362 citations

Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues

2003 • 361 citations

Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease

2003 • 349 citations

Role of the cytoskeleton during leukocyte responses

2004 • 348 citations

CCR7 Expression and Memory T Cell Diversity in Humans

2001 • 342 citations

Rapid leukocyte integrin activation by chemokines

2002 • 341 citations

α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

2001 • 330 citations

Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues

2005 • 307 citations

The Collagen Binding α1β1 Integrin VLA-1 Regulates CD8 T Cell-Mediated Immune Protection against Heterologous Influenza Infection

2004 • 300 citations

The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent.

1994 • 250 citations

Integration of inflammatory signals by rolling neutrophils

2002 • 245 citations

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

2002 • 243 citations

P-selectin Glycoprotein Ligand-1 Mediates L-Selectin–dependent Leukocyte Rolling in Venules

2003 • 240 citations

Lymphoid neogenesis:de novoformation of lymphoid tissue in chronic inflammation through expression of homing chemokines

2001 • 236 citations

Homing Phenotypes of Tumor-Specific CD8 T Cells Are Predetermined at the Tumor Site by Crosspresenting APCs

2005 • 231 citations

The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2

2004 • 227 citations

PECAM-1 (CD31) Homophilic Interaction Up-Regulates α6β1 on Transmigrated Neutrophils In Vivo and Plays a Functional Role in the Ability of α6 Integrins to Mediate Leukocyte Migration through the Perivascular Basement Membrane

2002 • 224 citations

L-Selectin Shedding Regulates Leukocyte Recruitment

2001 • 221 citations

Membranes as messengers in T cell adhesion signaling

2004 • 220 citations

T-cell trafficking in asthma: lipid mediators grease the way

2004 • 218 citations

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

2005 • 211 citations

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

2002 • 209 citations

Targeting leukocyte integrins in human diseases

2004 • 195 citations

The parting of the endothelium: miracle, or simply a junctional affair?

2000 • 186 citations

Signal Transducer and Activator of Transcription 6 Controls Chemokine Production and T Helper Cell Type 2 Cell Trafficking in Allergic Pulmonary Inflammation

2001 • 182 citations

Leukocyte Arrest During Cytokine-Dependent Inflammation In Vivo

2000 • 170 citations

Travellers in many guises: The origins and destinations of dendritic cells

2002 • 161 citations

Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease

2002 • 148 citations

Bimolecular Complex between Rolling and Firm Adhesion Receptors Required for Cell Arrest

2004 • 145 citations

Acquisition of Selectin Binding and Peripheral Homing Properties by CD4+ and CD8+ T Cells

1999 • 143 citations

Combinatorial signals by inflammatory cytokines and chemokines mediate leukocyte interactions with extracellular matrix

2001 • 142 citations

CXCR2- and E-Selectin–induced Neutrophil Arrest during Inflammation In Vivo

2004 • 135 citations

Reversing systemic inflammatory response syndrome with chemokine receptor pepducins

2005 • 134 citations

Absence of the Endothelial Oxidase AOC3 Leads to Abnormal Leukocyte Traffic In Vivo

2005 • 126 citations

Regulation of endothelial cell contacts during leukocyte extravasation

2002 • 122 citations

LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds

2003 • 115 citations

Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium

2003 • 104 citations

Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin α_Xβ₂

2005 • 94 citations

Rolling of Th1 Cells via P-Selectin Glycoprotein Ligand-1 Stimulates LFA-1-Mediated Cell Binding to ICAM-1

2005 • 89 citations

Targeting Monocyte Recruitment in CNS Autoimmune Disease

2002 • 88 citations

Arrest Chemokines

2003 • 65 citations

Role of chemokines in the development of secondary and tertiary lymphoid tissues

2003 • 58 citations

Blockade of α6 integrin inhibits IL-1β- but not TNF-α-induced neutrophil transmigration in vivo

2004 • 56 citations

Cutting Edge: Th2 Cell Trafficking into the Allergic Lung Is Dependent on Chemoattractant Receptor Signaling

2002 • 48 citations

Therapeutic Antagonists and the Conformational Regulation of the &amp;#946;2 Integrins

2004 • 46 citations

Glycosaminoglycans and the Regulation of Allergic Inflammation

2004 • 28 citations