Tumor-induced immune dysfunction: the macrophage connection

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Secretory products of macrophages.

1987 • 2,670 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

1996 • 1,206 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Lectins as Cell Recognition Molecules

1989 • 1,204 citations

Macrophages and angiogenesis

1994 • 1,123 citations

The origin and function of tumor-associated macrophages

1992 • 1,081 citations

The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells

1987 • 1,040 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?

1992 • 794 citations

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

1989 • 741 citations

Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

1996 • 606 citations

Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

1997 • 567 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Secretory products of macrophages and their physiological functions

1984 • 494 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

IL-4 down-regulates IL-1 and TNF gene expression in human monocytes.

1989 • 421 citations

Modulation of Macrophage Function by Transforming Growth Factor ?, Interleukin-4, and Interleukin-10

1993 • 393 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

Hydrogen peroxide secreted by tumor‐derived macrophages down‐modulates signal‐transducing zeta molecules and inhibits tumor‐specific T cell‐and natural killer cell‐mediated cytotoxicity

1996 • 364 citations

The host—tumor immune conflict: from immunosuppression to resistance and destruction

1997 • 363 citations

Macrophage-mediated suppression. I. Evidence for participation of both hdyrogen peroxide and prostaglandins in suppression of murine lymphocyte proliferation.

1980 • 345 citations

Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway.

1991 • 344 citations

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

1994 • 335 citations

EVIDENCE OF SUPPRESSOR CELL ACTIVITY IN SPLEENS OF MICE BEARING PRIMARY TUMORS INDUCED BY MOLONEY SARCOMA VIRUS

1974 • 325 citations

Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.

1991 • 312 citations

Transforming growth factor β: a matter of life and death

1994 • 306 citations

LFA-3, CD44, and CD45: Physiologic Triggers of Human Monocyte TNF and IL-1 Release

1990 • 300 citations

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

1991 • 266 citations

The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2).

1990 • 260 citations

Cancer Cell Invasion and Metastasis

1992 • 260 citations

The Mac-2 antigen is a galactose-specific lectin that binds IgE.

1989 • 251 citations

Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now?

1994 • 245 citations

Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin E2.

1994 • 244 citations

Macrophage-mediated tumor cell killing: regulation of expression of cytolytic activity by prostaglandin E.

1981 • 238 citations

Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine.

1990 • 230 citations

Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy.

1993 • 228 citations

Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function.

1988 • 227 citations

Cytokine networks in solid human tumors: regulation of angiogenesis

1994 • 209 citations

Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma.

1992 • 205 citations

The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene.

1996 • 204 citations

Macrophage arginine metabolism and the inhibition or stimulation of cancer.

1992 • 192 citations

Inhibition of Proliferation of Lymphoma Cells and T Lymphocytes by Suppressor Cells from Spleens of Tumor-Bearing Mice

1975 • 190 citations

Induction of prostaglandin E synthesis in normal and neoplastic macrophages: role for colony-stimulating factor(s) distinct from effects on myeloid progenitor cell proliferation.

1979 • 189 citations

Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self

1988 • 186 citations

Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity.

1995 • 186 citations

Nitric oxide involvement in tumor-induced immunosuppression.

1994 • 171 citations

Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression.

1992 • 168 citations

Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation.

1998 • 163 citations

Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes.

1988 • 162 citations

Immunosuppression and the Role of Suppressive Factors in Cancer

1977 • 162 citations

The Pathophysiology Of Tumor Necrosis Factors

1992 • 153 citations

Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex.

1995 • 150 citations

Molecular cloning of a human macrophage lectin specific for galactose.

1990 • 147 citations

Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-beta and nitric oxide.

1996 • 147 citations

Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.

1993 • 140 citations

Synergistic activation of human monocytes by granulocyte-macrophage colony-stimulating factor and IFN-gamma. Increased TNF-alpha but not IL-1 activity.

1988 • 139 citations

Cross-linking of both Fc gamma RI and Fc gamma RII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-Fc gamma R interactions. Functional activation of Fc gamma RII by treatment with proteases or neuraminidase.

1990 • 136 citations

Inhibition of rat mixed lymphocyte cultures by suppressor macrophages

1977 • 129 citations

Identification of the metastasis-associated, galactoside-binding lectin as a chimeric gene product with homology to an IgE-binding protein.

1989 • 126 citations

Human monocytes are stimulated for nitric oxide release in vitro by some tumor cells but not by cytokines and lipopolysaccharide

1994 • 118 citations

Involvement of inflammatory mediators in macrophage antitumor activity

1993 • 117 citations

Endogenous lectins from cultured cells: subcellular localization of carbohydrate-binding protein 35 in 3T3 fibroblasts.

1986 • 114 citations

Production of colony-stimulating factor by tumor cells and the factor-mediated induction of suppressor cells.

1988 • 112 citations

Suppressor cell activity in tumor-bearing mice. I. Dualistic inhibition by suppressor T lymphocytes and macrophages.

1978 • 111 citations

Inhibition of macrophage Ia expression by nitric oxide.

1994 • 111 citations

Identification of carbohydrate binding protein 35 in heterogeneous nuclear ribonucleoprotein complex

1988 • 106 citations

IFN-alpha induces autocrine production of IL-6 in myeloma cell lines.

1991 • 105 citations

Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase.

1993 • 104 citations

Origin and regulation of tumor-associated macrophages: the role of tumor-derived chemotactic factor

1986 • 103 citations

Suppressor Cells in the Spleens of Tumor-Bearing Mice: Enrichment by Centrifugation on Hypaque-Ficoll and Characterization of the Suppressor Population

1976 • 99 citations

Prostaglandin E2-Mediated Inactivation of Various Killer Lineage Cells by Tumor-Bearing Host Macrophages

1988 • 91 citations

Regulation of tumor necrosis factor gene expression in colorectal adenocarcinoma: in vivo analysis by in situ hybridization.

1989 • 90 citations

Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF‐β

1991 • 89 citations

Effects of recombinant murine tumor necrosis factor-alpha on immune function.

1990 • 89 citations

Role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma. II. Down-regulation of macrophage-mediated cytotoxicity by tumor-derived granulocyte-macrophage colony-stimulating factor.

1991 • 88 citations

Suppressor Cells in Tumor-Bearing Mice Capable of Nonspecific Blocking of in Vitro Immunization Against Transplant Antigens

1975 • 83 citations

Role of Fcγ receptors in cancer and infectious disease

1994 • 82 citations

Profiles of prostaglandin biosynthesis in sixteen established cell lines derived from human lung, colon, prostate, and ovarian tumors.

1988 • 80 citations

IL-10 inhibits prostaglandin E₂ production by lipopolysaccharide-stimulated monocytes

1994 • 77 citations

Control of nitric oxide synthase expression by transforming growth factor-β: Implications for homeostasis

1994 • 73 citations

Macrophage tumor necrosis factor-alpha release is induced by contact with some tumors.

1990 • 70 citations

Macrophage-Mediated Suppression of Natural Killer Cell Activity in Mice Bearing Lewis Lung Carcinoma2

1986 • 70 citations

Tumor-bearing mice exhibit a progressive increase in tumor antigen-presenting cell function and a reciprocal decrease in tumor antigen-responsive CD4+ T cell activity.

1992 • 69 citations

Inhibition of in vitro lymphoproliferative responses to tumor‐associated antigens by suppressor cells from rats bearing progressively growing gross leukemia virus‐induced tumors

1975 • 69 citations

Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production.

1990 • 67 citations

The role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma. I. Induction of regulatory macrophages in normal mice by the in vivo administration of rGM-CSF.

1991 • 65 citations

Suppression of in vitro lymphocyte stimulation in mice bearing primary moloney sarcoma virus-induced tumors

1974 • 64 citations

Aberrant antigen presentation by macrophages from tumor-bearing mice is involved in the down-regulation of their T cell responses.

1995 • 63 citations

Interleukin-10 is a potent inhibitor of tumor cytotoxicity by human monocytes and alveolar macrophages

1994 • 63 citations

Distinct tumor cell membrane constituents activate human monocytes for tumor necrosis factor synthesis.

1990 • 61 citations

Prostaglandin E Production by Lewis Lung Carcinoma: Mechanism for Tumor Establishment In Vivo<xref ref-type="fn" rid="FN2">2</xref>

1984 • 61 citations

Macrophage requirement for growth of a murine fibrosarcoma

1978 • 60 citations

Depressed T cell proliferative responses in Hodgkin's disease: role of monocyte-mediated suppression via prostaglandins and hydrogen peroxide.

1982 • 59 citations

Tumor-derived cytokines induce bone marrow suppressor cells that mediate immunosuppression through transforming growth factor β

1992 • 58 citations

Interleukin-12 Gene-Expression of Macrophages Is Regulated by Nitric Oxide

1996 • 58 citations

IL-10 Inhibits Alloreactive Cytotoxic T Lymphocyte Generation in Vivo

1994 • 57 citations

Characterization of immunosuppressive functions of murine peritoneal macrophages induced with various agents

1992 • 57 citations

T-cell based cancer immunotherapy: direct or redirected tumor-cell recognition?

1994 • 56 citations

TGF-beta1 inhibits both endotoxin-induced prostaglandin synthesis and expression of the TIS10/prostaglandin synthase 2 gene in murine macrophages

1994 • 56 citations

Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages

1994 • 55 citations

Differential induction of prostaglandin E2-dependent and -independent immune suppressor cells by tumor-derived GM-CSF and M-CSF

1993 • 53 citations

Macrophage-tumor cell associations: a factor in metastasis of breast cancer?

1993 • 52 citations

Interleukin‐4‐mediated tumor suppression in nude mice involves interferon‐γ

1992 • 48 citations

Macrophage deactivation. Altered kinetic properties of superoxide-producing enzyme after exposure to tumor cell-conditioned medium.

1986 • 48 citations

Macrophage tumoricidal mechanisms

1993 • 46 citations

Switching on the macrophage-mediated suppressor mechanism by tumor cells to evade host immune surveillance.

1980 • 44 citations

Tumor Growth Alters T Cell and Macrophage Production of and Responsiveness to Granulocyte-Macrophage Colony-Stimulating Factor: Partial Dysregulation through Interleukin-10

1994 • 44 citations

Two Distinct Populations of Suppressor Cells in the Spleens of Mice Bearing Methylcholanthrene-Induced Tumors

1978 • 44 citations

Significance of Suppressor Macrophages for Immunosurveillance of Tumor-Bearing Mice<xref ref-type="fn" rid="FN2">2</xref>

1987 • 43 citations

Regulation of murine macrophage function by IL-4: IL-4 and IFN-gamma differentially regulate macrophage tumoricidal activation.

1993 • 42 citations

Antitumor Activity of Interleukin-12

1994 • 39 citations

Macrophages as Regulators of Immune Responses Against Tumors

1980 • 38 citations

Tumor growth increases la− macrophage synthesis of tumor necrosis factor-α and prostaglandin E2: changes in macrophage suppressor activity

1993 • 37 citations

Potentiation of macrophage tumor cytostasis by tumor-induced ascites.

1981 • 37 citations

Shifts in macrophage (Mφ) surface phenotypes during tumor growth: Association of Mac-2+ and Mac-3+ Mφ with immunosuppressive activity

1987 • 35 citations

Peritoneal macrophages exposed to purified macrophage colony-stimulating factor (M-CSF) suppress mitogen- and antigen-stimulated lymphocyte proliferation.

1986 • 35 citations

Physically Damaged Extracellular Matrix Induces TNF‐α Secretion by Interacting Resting CD4⁺ T Cells and Macrophages

1993 • 34 citations

Alteration in IL-1 and arginase activity of tumor-associated macrophages: a role in the promotion of tumor growth

1996 • 34 citations

Purification of macrophage deactivating factor.

1990 • 33 citations

The activation state of macrophage subpopulations from a murine fibrosarcoma

1980 • 33 citations

Stimulation of immune-suppressive bone marrow cells by colony-stimulating factors.

1990 • 33 citations

Suppression of antitumor immunity by macrophages in spleens of mice bearing a large MOPC-315 tumor

1984 • 33 citations

Taxol, a microtubule-stabilizing antineoplastic agent, differentially regulates normal and tumor-bearing host macrophage nitric oxide production

1997 • 32 citations

Anti-tumor activity of recombinant tumor necrosis factor on mouse fibrosarcoma in vivo and in vitro.

1988 • 32 citations

Suppression of T Lymphocyte Proliferation during Lymphoma Growth in Mice : Role of PGE2-Producing Suppresser Macrophages

1982 • 32 citations

Characterization of Macrophage Subsets Regulating Murine Natural Killer Cell Activity

1990 • 31 citations

Decreased macrophage‐mediated cytotoxicity in mammary‐tumor‐bearing mice is related to alteration of nitric‐oxide production and/or release

1995 • 30 citations

Changes in Macrophage Populations: Phenotypic Differences between Normal and Tumor-Bearing Host Macro phages

1989 • 30 citations

CHARACTERISTICS OF MONONUCLEAR PHAGOCYTES FROM DIFFERENT TISSUES

1981 • 29 citations

Variations in Macrophage Antigen Phenotype: A Correlation Between Ia Antigen Reduction and Immune Dysfunction During Tumor Growth

1986 • 27 citations

Interferon-γ inhibits tumor antigen presentation by epidermal antigen-presenting cells

1994 • 27 citations

Pasl expression on epithelial cells: the Bottazzo-Feldmann hypothesis revisited

1997 • 27 citations

Prostaglandin E2 Production by Mac-2+ Macrophages: Tumor-Induced Population Shift

1987 • 27 citations

Anti-tumoral effect of GM-CSF with or without cytokines and monoclonal antibodies in solid tumors

1996 • 27 citations

Tumoricidal Activity of Alveolar and Peritoneal Macrophages of C57BL/6 Mice Bearing Metastatic or Nonmetastatic Variants of Lewis Lung Carcinoma

1991 • 25 citations

Suppressor cell activity in tumor-bearing mice. II. Inhibition of DNA synthesis and DNA polymerases by TBH splenic suppressor cells.

1978 • 25 citations

Regulation of macrophage suppression and cytotoxicity by interferon role of Ia-bearing macrophages.

1982 • 25 citations

Tumor Cell-Triggered Macrophage-Mediated Suppression of the T-Cell Cytotoxic Response to Tumor-Associated Antigens. I. Characterization of the Cell Components for Induction of Suppression<xref ref-type="fn" rid="FN2">2</xref>

1982 • 24 citations

Down-Regulation of Macrophage I-A Expression in Tumor-Bearing Mice

1990 • 24 citations

Tumor-induced alteration in macrophage accessory cell activity on autoreactive T cells

1989 • 23 citations

Suppression of Antibody-Sensitized Tumor Cells by Macrophages: Insufficient Supply or Activation of Macrophages within Large Tumors

1979 • 23 citations

Transforming growth factor β1 regulation of macrophage activation depends on the triggering stimulus

1993 • 23 citations

Fibrosarcoma-induced increase in macrophage tumor necrosis factor α synthesis suppresses T cell responses

1993 • 22 citations

Peritoneal and Splenic Macrophage Functions in the Tumor-Bearing Host

1995 • 22 citations

Inhibition of mitogen and immune blastogenesis by two distinct populations of suppressor cells present in the spleens of fibrosarcoma‐bearing mice: Adoptive transfer of suppression

1978 • 21 citations

In vitro replication dynamics of human culture-derived macrophages in a long term serum-free system.

1993 • 21 citations

Induction of suppressor cells by a tumor-derived suppressor factor

1985 • 20 citations

Tumor‐associated macrophages stimulate the proliferation of murine tumor cells surviving treatment with the oncolytic cyclophosphamide analogue ASTA Z‐7557: In vivo implications

1984 • 20 citations

Tumor modulation of autoreactivity: Decreased macrophage and autoreactive T cell interactions

1990 • 20 citations

Regulation of Systemic Macrophage IL-1 Gene Transcription: The Involvement of Tumor-Derived Macrophage Growth Factor, CSF-1

1989 • 19 citations

Correlation of macrophage‐mediated tumor‐cell lysis with the production of macrophage cytolytic factor (CF). preliminary characterization of a factor inhibiting cf production

1986 • 19 citations

Changes in Splenic Macrophage Mac Antigen Expression During Tumor Growth: A Kinetic Study of Accessory Cell Function and Antigen-Defined Phenotypes

1986 • 19 citations

Tumor-Induced Macrophage Tumor Necrosis Factor-α Production Suppresses Autoreactive T Cell Proliferation

1993 • 19 citations

Suppressor Monocytes in Human Disease: A Review

1980 • 17 citations

In vitro immune blastogenesis during contact sensitivity in tumor-bearing mice

1978 • 17 citations

Correlation of tumor necrosis factor and prostaglandin E2 production of monocytes in bladder cancer patients

1989 • 17 citations

The Respiratory Burst of Phagocytes

1988 • 16 citations

Regulation of T-cell mixed lymphocyte reaction reactivity: Demonstration of enhancing and inhibitory activity in tumor-bearing host macrophage supernatants

1979 • 16 citations

Interferon-γ reduces tumor-induced Ia− macrophage-mediated suppression: role of prostaglandin E2, Ia, and tumor necrosis factor-α

1993 • 16 citations

Activity of human peritoneal macrophages against a human tumor: role of tumor necrosis factor-α, PGE2 and nitrite, in vitro studies

1993 • 16 citations

Cytokines and suppressor macrophages cause tumor-bearing host CD8+ T cells to suppress recognition of allogeneic and syngeneic MHC class II molecules

1992 • 16 citations

Tumor-induced modulation of macrophage class II MHC molecule mRNA expression

1993 • 15 citations

Ability of cancer patients' macrophages to kill autologous tumor targets: Effect of prostaglandin inhibitors on cytotoxicity

1984 • 15 citations

Development and mechanisms of interferon resistance

1990 • 15 citations

IA⁻Macrophages and Cytokine Networks Contribute to Tumor-Induced Suppression of CD4⁺Autoreactive T Cells

1993 • 14 citations

Tumor growth and adherence change the expression of macrophage Mac-2

1993 • 14 citations

Level of Macrophage Induction During Tumor Growth: Primed or Activated?

1983 • 14 citations

Down-regulation of cytotoxic T lymphocyte development by a minor stimulating locus-induced suppressor cascade that involves Lyt-1+ suppressor T cells, IA- macrophages, and their factors.

1988 • 14 citations

Impaired NK Response of Cancer Patients to IFN‐α but Not to IL‐2: Correlation with Serum Immunosuppressive Acidic Protein (IAP) and Role of Suppressor Macrophage

1992 • 14 citations

Normal and tumor-bearing host macrophage responses: variability in accessory function, surface markers, and cell-cycle kinetics

1990 • 13 citations

Augmentation of antitumor immunity using genetically M-CSF-expressing L1210 cells.

1996 • 13 citations

Study of natural lipocortin I. A potent mediator for macrophage-mediated immunosuppression in tumor-bearing mice.

1993 • 13 citations

Immunoregulation of the Mixed Lymphocyte Reaction by Macrophage-Derived Factors: Functional and Biochemical Separation of Enhancing and Inhibitory Factors

1983 • 12 citations

Significance of suppressor macrophages for immunosurveillance of tumor-bearing mice

1987 • 12 citations

Modulation of tumoricidal function in alveolar macrophages from lung cancer patients by interleukin-6

1997 • 12 citations

Two‐color flow cytometric analysis of the expression of MAC and MHC Class II antigens on macrophages during tumor growth

1990 • 12 citations

Suppression by Interleukin 4 of Activation of Human Blood Monocytes to the Tumoricidal State

1990 • 11 citations

Promotion of Macrophage-Stimulated Autoreactive T Cell Proliferation by Interleukin-10: Counteraction of Macrophage Suppressor Activity During Tumor Growth

1995 • 11 citations

Inhibitory factors derived from human tumors: Isolation of factors which suppress macrophage mediated cytotoxicity

1983 • 11 citations

Modulation of Alloreactivity by Mac-1+, -2+, and -3+ Macrophages From Normal and Tumor-Bearing Hosts: Flow Cytofluorometrically Separated Macrophages

1990 • 11 citations

Granulocyte-macrophage colony-stimulating factor enhances macrophage accessory function in Con A-stimulated T-cell proliferation

1990 • 11 citations

Role of colony-stimulating factor-1 in macrophage activation in tumor-bearing mice.

1992 • 11 citations

Increased sensitivity of tumor-bearing host macrophages to interleukin-10: a counter-balancing action to macrophage-mediated suppression.

1994 • 11 citations

Normal and tumor-bearing host macrophage factor-mediated modulation of mixed-lymphocyte reaction responsiveness: Separation of T-lymphocyte subset susceptibility to enhancing and inhibitory factors

1984 • 10 citations

Some aspects of the macrophage-cancer relationship

1993 • 10 citations

Interleukin-4 production by the malignant cell line HUT78.

1993 • 10 citations

Immune rejection of tumor cells: in vivo significance of anti-tumor in vitro immune reactions.

1975 • 9 citations

Suppressor macrophages.

1994 • 9 citations

Antiinflammatory effects of neoplasms

1993 • 9 citations

Suppressor cell activity in tumor-bearing mice. III. Co-purification of a factor inhibiting cellular DNA synthesis and DNA polymerase activity.

1981 • 8 citations

Human monocyte tumouristatic ability: Modulation by cytokines and tumour cell products

1990 • 8 citations

Suppression of the Immune Response in Tumor-Bearing Mice. III. Induction of Functionally Suppressive Antigen-Driven Macrophages

1983 • 8 citations

Tumor growth changes the contribution of granulocyte-macrophage colony-stimulating factor during macrophage-mediated suppression of allorecognition

1992 • 8 citations

COOPERATION BETWEEN IL-4 AND IL-10 RESULTS IN INHIBITION OF DTH RESPONSES

1993 • 6 citations

Macrophage Priming and Activation During Fibrosarcoma Growth: Expression of c-myb, c-myc, c-fos, and c-fms

1994 • 6 citations

Macrophages stimulated by receptor-ligand interactions exhibit differences in cell-cycle kinetics during tumor growth: stimulation at Mac-1 and Mac-3 receptors alters DNA synthesis

1992 • 5 citations

Granules of human CD3+ large granular lymphocytes contain a macrophage regulating factor(s) that induces macrophage H202 production and tumoricidal activity but decreases cell surface la antigen expression

1991 • 2 citations