Ammonium Trichloro(dioxoethylene-o,o′)tellurate (AS101) Sensitizes Tumors to Chemotherapy by Inhibiting the Tumor Interleukin 10 Autocrine Loop

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

2002 • 1,027 citations

Stat proteins and oncogenesis

2002 • 776 citations

Stat proteins and oncogenesis

2002 • 660 citations

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

1998 • 496 citations

Phosphorylation of Bcl2 and regulation of apoptosis

2001 • 453 citations

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways

1998 • 442 citations

IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.

1995 • 420 citations

The host—tumor immune conflict: from immunosuppression to resistance and destruction

1997 • 363 citations

Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression.

1994 • 314 citations

Interleukin-10

1992 • 303 citations

Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cytotoxic drugs.

2001 • 293 citations

TGF-beta contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice.

1996 • 274 citations

Cooperation between STAT3 and c-Jun Suppresses Fas Transcription

2001 • 248 citations

Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules

1997 • 239 citations

Serum interleukin-10 in non-Hodgkin's lymphoma: a prognostic factor

1993 • 239 citations

Prognostic Significance of Circulating IL-10 and IL-6 Serum Levels in Colon Cancer Patients Undergoing Surgery

2002 • 221 citations

Protein Tyrosine Kinase Inhibitors as Novel Therapeutic Agents

1999 • 217 citations

A new immunomodulating compound (AS-101) with potential therapeutic application

1987 • 184 citations

Interleukin 10 is expressed in human gliomas in vivo and increases glioma cell proliferation and motility in vitro.

1997 • 176 citations

Interleukin-10 levels are often elevated in serum of adults with Hodgkin's disease and are associated with inferior failure-free survival

1999 • 161 citations

Increased interleukin-10 serum levels in patients with solid tumours

1996 • 157 citations

Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10.

2003 • 145 citations

Interleukin‐10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl‐2

1997 • 141 citations

Anti-IL-10 Therapeutic Strategy Using the Immunomodulator AS101 in Protecting Mice from Sepsis-Induced Death: Dependence on Timing of Immunomodulating Intervention

2002 • 132 citations

Lack of interleukin‐2 (IL‐2) expression and selective expression of IL‐10 mRNA in human renal cell carcinoma

1995 • 129 citations

Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.

2001 • 127 citations

Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop

1996 • 124 citations

Treatment of Recurrent Glioblastoma Multiforme Using Fractionated Stereotactic Radiosurgery and Concurrent Paclitaxel

2000 • 123 citations

Serum interleukin-10 levels as a prognostic factor in advanced non-small cell lung cancer patients

2013 • 108 citations

Predominance of TH1 Response in Tumor-Bearing Mice and Cancer Patients Treated With AS 101

1996 • 90 citations

Interleukin‐10 promotes B16‐melanoma growth by inhibition of macrophage functions and induction of tumour and vascular cell proliferation

2002 • 87 citations

Escape from Host-Antitumor Immunity

1997 • 81 citations

Salvage chemotherapy with paclitaxel for recurrent primary brain tumors.

1995 • 78 citations

Delay in the onset of systemic lupus erythematosus following treatment with the immunomodulator AS101: association with IL-10 inhibition and increase in TNF-alpha levels.

1997 • 70 citations

Bone marrow-sparing and prevention of alopecia by AS101 in non-small-cell lung cancer patients treated with carboplatin and etoposide.

1995 • 66 citations

Circulating Levels of Interleukin-10 and Interleukin-6 in Gastric and Colon Cancer Patients Before and After Surgery: Relationship with Radicality and Outcome

2002 • 64 citations

Prognostic significance of Bcl-2, Bcl-xL/S, Bax and Bak expressions in colorectal carcinomas.

1999 • 63 citations

Synergistic anti-tumoral effect of paclitaxel (taxol)+AS101 in a murine model of B16 melanoma: Association with ras-dependent signal-transduction pathways

2000 • 48 citations

Antisense-mediated inhibition of the bcl-2 gene induces apoptosis in human malignant glioma

2000 • 40 citations

The Immunomodulator AS-101 Inhibits IL-10 Release and Augments TNFα and IL-1α Release by Mouse and Human Mononuclear Phagocytes

1997 • 39 citations

Production of the Novel Mesangial Autocrine Growth Factors GDNF and IL-10 Is Regulated by the Immunomodulator AS101

2003 • 37 citations

Role of endogenous cytokines secretion in radioprotection conferred by the immunomodulator ammonium trichloro(dioxyethylene-0-0')tellurate

1995 • 37 citations

Expression of Bax and bcl-2 proteins, regulators of programmed cell death, in human brain tumors

1997 • 35 citations

Up-Regulation by Ammonium Trichloro(Dioxoethylene-0,0′) Tellurate (AS101) of Fas/Apo-1 Expression on B16 Melanoma Cells: Implications for the Antitumor Effects of AS101

1998 • 29 citations

The Immunomodulator AS101 Restores TH1Type of Response Suppressed byBabesia rodhainiin BALB/c Mice

1998 • 26 citations

In vitro assessment of Taxol for human glioblastoma

1995 • 24 citations

The protective role of ammonium trichloro(dioxoethylene-O,O')tellurate in combination with several cytotoxic drugs acting by different mechanisms of action.

1993 • 20 citations