Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

NF-κB in cancer: from innocent bystander to major culprit

2002 • 2,457 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

Safety and antitumor activity of recombinant soluble Apo2 ligand

1999 • 2,215 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

IAP proteins: blocking the road to death's door

2002 • 1,753 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

2002 • 1,325 citations

A matter of life and death

2002 • 1,251 citations

Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

1998 • 1,177 citations

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL

1997 • 1,119 citations

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

2000 • 968 citations

Apo2L/TRAIL and its death and decoy receptors

2003 • 851 citations

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

2000 • 847 citations

The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

1997 • 829 citations

PKR; a sentinel kinase for cellular stress

1999 • 823 citations

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

2000 • 792 citations

Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.

2003 • 790 citations

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

2001 • 757 citations

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

2002 • 739 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

2000 • 651 citations

A novel receptor for Apo2L/TRAIL contains a truncated death domain

1997 • 650 citations

Cloning and Characterization of TRAIL-R3, a Novel Member of the Emerging TRAIL Receptor Family

1997 • 634 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice

2002 • 608 citations

Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

1997 • 566 citations

c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

2002 • 565 citations

Inhibition of Fas death signals by FLIPs

1998 • 531 citations

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

2000 • 526 citations

Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8

2001 • 521 citations

Tumor-cell resistance to death receptor–induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax

2002 • 515 citations

Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

1999 • 477 citations

The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex

2002 • 475 citations

Monocyte-mediated Tumoricidal Activity via the Tumor Necrosis Factor–related Cytokine, TRAIL

1999 • 470 citations

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO

2002 • 448 citations

Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

2002 • 447 citations

Triggering Cell Death

1999 • 425 citations

Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail)

1999 • 408 citations

TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

2001 • 397 citations

Caspase-10 is an initiator caspase in death receptor signaling

2001 • 387 citations

Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression

2002 • 386 citations

Molecular determinants of response to TRAIL in killing of normal and cancer cells.

2000 • 379 citations

FOXO Proteins Regulate Tumor Necrosis Factor-related Apoptosis Inducing Ligand Expression

2002 • 368 citations

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Is an Inhibitor of Autoimmune Inflammation and Cell Cycle Progression

2000 • 357 citations

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8

2002 • 354 citations

MAPK/ERK Overrides the Apoptotic Signaling from Fas, TNF, and TRAIL Receptors

2001 • 337 citations

TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

1997 • 331 citations

Expression and Function of TNF-Related Apoptosis-Inducing Ligand on Murine Activated NK Cells

1999 • 330 citations

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

1998 • 327 citations

An Inducible Pathway for Degradation of FLIP Protein Sensitizes Tumor Cells to TRAIL-induced Apoptosis

2002 • 317 citations

Characterization of two receptors for TRAIL¹

1997 • 293 citations

IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression.

1999 • 273 citations

Elevated Akt Activity Protects the Prostate Cancer Cell Line LNCaP from TRAIL-induced Apoptosis

2001 • 272 citations

Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells.

2002 • 272 citations

Antiviral response by natural killer cells throughTRAIL gene induction by IFN-α/β

2001 • 262 citations

A Unique Zinc-Binding Site Revealed by a High-Resolution X-ray Structure of Homotrimeric Apo2L/TRAIL

2000 • 259 citations

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.

1999 • 247 citations

Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: correlation with TRAIL/Apo2L induction in melanoma cell lines.

2001 • 245 citations

Temperature-sensitive Differential Affinity of TRAIL for Its Receptors

2000 • 244 citations

Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

2000 • 239 citations

Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.

1999 • 236 citations

IFN-γ Mediates a Novel Antiviral Activity Through Dynamic Modulation of TRAIL and TRAIL Receptor Expression

1999 • 220 citations

Differential Localization and Regulation of Death and Decoy Receptors for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Human Melanoma Cells

2000 • 213 citations

Pretreatment with paclitaxel enhances apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels.

2001 • 204 citations

Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria.

2001 • 203 citations

Apo2L/TRAIL and Bcl-2–related proteins regulate type I interferon–induced apoptosis in multiple myeloma

2001 • 201 citations

Roles of TNF-Related Apoptosis-Inducing Ligand in Experimental Autoimmune Encephalomyelitis

2001 • 194 citations

Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L–induced apoptosis of human acute leukemia cells

2000 • 184 citations

Characterization of the in vivo function of TNF-α-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice

2002 • 177 citations

Identification of X-linked Inhibitor of Apoptosis-associated Factor-1 as an Interferon-stimulated Gene That Augments TRAIL Apo2L-induced Apoptosis

2002 • 176 citations

Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice.

2002 • 173 citations

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-κB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

2001 • 166 citations

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative–(BMS 247550) and Apo-2L/TRAIL–induced apoptosis

2002 • 162 citations

Rare loss-of-function mutation of a death receptor gene in head and neck cancer.

1998 • 160 citations

Inositol Hexakisphosphate Kinase 2 Mediates Growth Suppressive and Apoptotic Effects of Interferon-β in Ovarian Carcinoma Cells

2001 • 158 citations

Identification of Inhibitors of TRAIL-induced Death (ITIDs) in the TRAIL-sensitive Colon Carcinoma Cell Line SW480 Using a Genetic Approach

2001 • 157 citations

Intracellular regulation of tumor necrosis factor–related apoptosis-inducing ligand–induced apoptosis in human multiple myeloma cells

2002 • 155 citations

T cells require TRAIL for optimal graft-versus-tumor activity

2002 • 151 citations

Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis

2001 • 151 citations

Cysteine 230 Is Essential for the Structure and Activity of the Cytotoxic Ligand TRAIL

2000 • 145 citations

Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL.

1998 • 142 citations

Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L).

2002 • 132 citations

Innate Direct Anticancer Effector Function of Human Immature Dendritic Cells. II. Role of TNF, Lymphotoxin-α1β2, Fas Ligand, and TNF-Related Apoptosis-Inducing Ligand

2002 • 131 citations

Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP

2000 • 128 citations

Direct stimulation of apoptotic signaling by soluble Apo2l/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells.

2001 • 122 citations

Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells.

2000 • 120 citations

Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines.

1997 • 120 citations

TRAIL (APO-2L) induces apoptosis in human prostate cancer cells that is inhibitable by Bcl-2

2001 • 119 citations

Failure of Bcl‐2 to block cytochrome c redistribution during TRAIL‐induced apoptosis

2000 • 109 citations

Death and survival: viral regulation of TNF signaling pathways

2003 • 108 citations

Long-term tumor-free survival from treatment with the GFP–TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells

2002 • 108 citations

Pro-survival Function of Akt/Protein Kinase B in Prostate Cancer Cells

2001 • 108 citations

Cutting Edge: Lymphocyte Inhibitor of TRAIL (TNF-Related Apoptosis-Inducing Ligand): A New Receptor Protecting Lymphocytes from the Death Ligand TRAIL

1998 • 104 citations

Pediatric rhabdomyosarcoma cell lines are resistant to Fas-induced apoptosis and highly sensitive to TRAIL-induced apoptosis.

2000 • 95 citations

Targeted expression of green fluorescent protein/tumor necrosis factor-related apoptosis-inducing ligand fusion protein from human telomerase reverse transcriptase promoter elicits antitumor activity without toxic effects on primary human hepatocytes.

2002 • 89 citations

REGULATION OF APO-2 LIGAND/TRAIL EXPRESSION IN NK CELLS—INVOLVEMENT IN NK CELL-MEDIATED CYTOTOXICITY

1999 • 83 citations

TRAIL-induced eradication of primary tumour cells from multiple myeloma patient bone marrows is not related to TRAIL receptor expression or prior chemotherapy

2001 • 80 citations

IFN-β Pretreatment Sensitizes Human Melanoma Cells to TRAIL/Apo2 Ligand-Induced Apoptosis

2002 • 78 citations

Genomic Organization and Transcriptional Regulation of Human Apo2/TRAIL Gene

2000 • 76 citations

Antitumor Activity and Prolonged Expression from a TRAIL-Expressing Adenoviral Vector

2002 • 72 citations

Ionizing radiation-induced, Bax-mediated cell death is dependent on activation of cysteine and serine proteases.

1999 • 68 citations

Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics

2002 • 67 citations

Mitochondria-dependent and -independent mechanisms in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis are both regulated by interferon-γ in human breast tumour cells

2002 • 59 citations

Ectopic Expression of Bcl-2 and Bcl-xL Inhibits Apoptosis Induced by TNF-Related Apoptosis-Inducing Ligand (TRAIL) Through Suppression of Caspases-8, 7, and 3 and BID Cleavage in Human Acute Myelogenous Leukemia Cell Line HL-60

2002 • 56 citations

Activation of protein kinase C inhibits TRAIL-induced caspases activation, mitochondrial events and apoptosis in a human leukemic T cell line

2001 • 51 citations

Human myeloma cell apoptosis induced by interferon‐α

1998 • 48 citations

Bcl-2 over-expression and activation of protein kinase C suppress the Trail-induced apoptosis in Jurkat T cells

2001 • 39 citations

Three polymorphisms in the 3′ UTR of the TRAIL (TNF-related apoptosis-inducing ligand) gene

2001 • 25 citations

T cells require TRAIL for optimal graft-versus-tumor activity

2002 • 24 citations