Myeloid C-type lectins in innate immunity

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

NK CELL RECOGNITION

2004 • 2,685 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Innate immune recognition of viral infection

2006 • 1,790 citations

Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2

2003 • 1,593 citations

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 • 1,381 citations

Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin

2006 • 1,344 citations

Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance

2002 • 1,296 citations

Immune Inhibitory Receptors

2000 • 1,283 citations

The C‐type lectin‐like domain superfamily

2005 • 1,273 citations

Dectin-1 Mediates the Biological Effects of β-Glucans

2003 • 1,167 citations

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells

2005 • 1,142 citations

Dectin-1: a signalling non-TLR pattern-recognition receptor

2005 • 1,083 citations

Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

2002 • 1,037 citations

Regulation of Phagosome Maturation by Signals from Toll-Like Receptors

2004 • 982 citations

DC-SIGN: escape mechanism for pathogens

2003 • 898 citations

Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins

2005 • 844 citations

Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

2006 • 794 citations

BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction

2001 • 749 citations

Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments

2005 • 638 citations

The Dendritic Cell-Specific Adhesion Receptor DC-SIGN Internalizes Antigen for Presentation to T Cells

2002 • 613 citations

C-type lectin-like domains

1999 • 609 citations

Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling

1980 • 574 citations

The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments

2000 • 546 citations

A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells

2005 • 530 citations

Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance

2006 • 525 citations

Involvement of LOX-1 in Dendritic Cell-Mediated Antigen Cross-Presentation

2002 • 524 citations

DC-SIGN-Mediated Internalization of HIV Is Required for Trans-Enhancement of T Cell Infection

2002 • 513 citations

Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

2005 • 501 citations

Self- and Nonself-Recognition by C-Type Lectins on Dendritic Cells

2004 • 500 citations

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2

2005 • 499 citations

The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus

2005 • 492 citations

The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis

2005 • 482 citations

Mannose Receptor-Mediated Regulation of Serum Glycoprotein Homeostasis

2002 • 477 citations

Identification of a Novel, Dendritic Cell-associated Molecule, Dectin-1, by Subtractive cDNA Cloning

2000 • 457 citations

Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages

2004 • 443 citations

Aspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific β-Glucan Display

2005 • 421 citations

Molecular Bases for the Recognition of Tyrosine-based Sorting Signals

1999 • 414 citations

Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells

1998 • 385 citations

Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN

2005 • 382 citations

The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose

2006 • 368 citations

Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program

2003 • 361 citations

Ligands for the β-Glucan Receptor, Dectin-1, Assigned Using “Designer” Microarrays of Oligosaccharide Probes (Neoglycolipids) Generated from Glucan Polysaccharides

2005 • 347 citations

Helicobacter pyloriModulates the T Helper Cell 1/T Helper Cell 2 Balance through Phase-variable Interaction between Lipopolysaccharide and DC-SIGN

2004 • 306 citations

Gram-negative Bacteria-binding Protein, a Pattern Recognition Receptor for Lipopolysaccharide and β-1,3-Glucan That Mediates the Signaling for the Induction of Innate Immune Genes in Drosophila melanogaster Cells

2000 • 297 citations

You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling

2006 • 251 citations

Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum

2006 • 244 citations

Human Macrophage C-Type Lectin Specific for Galactose andN-Acetylgalactosamine Promotes Filovirus Entry

2004 • 243 citations

DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production

2006 • 239 citations

Microbial Recognition Via Toll-Like Receptor-Dependent and -Independent Pathways Determines the Cytokine Response of Murine Dendritic Cell Subsets to CD40 Triggering

2002 • 231 citations

Characterization of β-Glucan Recognition Site on C-Type Lectin, Dectin 1

2004 • 221 citations

Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells

2005 • 216 citations

Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells

2000 • 214 citations

Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells

1999 • 208 citations

Siglecs in innate immunity

2005 • 208 citations

The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide ofStreptococcus pneumoniaein the marginal zone of mouse spleen

2003 • 202 citations

A Pattern-recognition Protein for β-1,3-Glucan

2000 • 201 citations

Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45

2006 • 192 citations

Normal Host Defense during Systemic Candidiasis in Mannose Receptor-Deficient Mice

2002 • 179 citations

Birbeck Granules Are Subdomains of Endosomal Recycling Compartment in Human Epidermal Langerhans Cells, Which Form Where Langerin Accumulates

2002 • 177 citations

Characterization of carbohydrate recognition by langerin, a C-type lectin of Langerhans cells

2003 • 175 citations

The mannose-binding lectin: a prototypic pattern recognition molecule

2005 • 171 citations

Dendritic Cells Recognize Tumor-Specific Glycosylation of Carcinoembryonic Antigen on Colorectal Cancer Cells through Dendritic Cell–Specific Intercellular Adhesion Molecule-3–Grabbing Nonintegrin

2005 • 167 citations

SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran

2003 • 165 citations

From Pattern Recognition Receptor to Regulator of Homeostasis: The Double-Faced Macrophage Mannose Receptor

2004 • 160 citations

Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation

2004 • 151 citations

Identification and Characterization of a Novel Human Myeloid Inhibitory C-type Lectin-like Receptor (MICL) That Is Predominantly Expressed on Granulocytes and Monocytes

2004 • 145 citations

Inhibition of Immune Responses by ITAM-Bearing Receptors

2006 • 144 citations

The role of dendritic cell C-type lectin receptors in HIV pathogenesis

2003 • 136 citations

B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands

2006 • 118 citations

Absence of the Macrophage Mannose Receptor in Mice Does Not Increase Susceptibility toPneumocystis cariniiInfection In Vivo

2003 • 115 citations

Targeting antigens to dendritic cells in vivo

2006 • 112 citations

Molecular Cloning and Characterization of a Novel Mouse Macrophage C-type Lectin, mMGL2, Which Has a Distinct Carbohydrate Specificity from mMGL1

2002 • 110 citations

Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production

2005 • 101 citations

DCIR Acts as an Inhibitory Receptor Depending on its Immunoreceptor Tyrosine-Based Inhibitory Motif11A preliminary report of these results was presented by the first author at the 61st annual meeting of SID in Chicago in the session “General Immunology”.

2002 • 101 citations

Interactions of DC‐SIGN with Mac‐1 and CEACAM1 regulate contact between dendritic cells and neutrophils

2005 • 98 citations

Dendritic Cell Immunoactivating Receptor, a Novel C-type Lectin Immunoreceptor, Acts as an Activating Receptor through Association with Fc Receptor γ Chain

2003 • 90 citations

Recognition of tumor glycans by antigen-presenting cells

2005 • 89 citations

Specific ICAM‐3 grabbing nonintegrin‐related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcuspneumoniae infection

2005 • 88 citations

The human C‐type lectin CLECSF8 is a novel monocyte/macrophage endocytic receptor

2003 • 86 citations

Association of SIGNR1 with TLR4–MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria

2005 • 84 citations

Involvement of Dectin-2 in Ultraviolet Radiation-Induced Tolerance

2003 • 81 citations

Dendritic Cell-Associated Lectin-1: A Novel Dendritic Cell-Associated, C-Type Lectin-Like Molecule Enhances T Cell Secretion of IL-4

2002 • 79 citations

The C-type Lectin Receptor Endo180 Displays Internalization and Recycling Properties Distinct from Other Members of the Mannose Receptor Family

2002 • 75 citations

Regulation of lutropin circulatory half-life by the mannose/N-acetylgalactosamine-4-SO4 receptor is critical for implantation in vivo

2002 • 66 citations

Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: A new mechanism of action for SHP-2

2005 • 61 citations

Identification of Sialoadhesin as a Dominant Lymph Node Counter-receptor for Mouse Macrophage Galactose-type C-type Lectin 1

2004 • 51 citations

Retardation of removal of radiation-induced apoptotic cells in developing neural tubes in macrophage galactose-type C-type lectin-1-deficient mouse embryos

2005 • 35 citations

SRCL/CL-P1 Recognizes GalNAc and a Carcinoma-Associated Antigen, Tn Antigen

2003 • 28 citations

Identification and Characterization of Endogenous Langerin Ligands in Murine Extracellular Matrix

2006 • 18 citations

Redistributions of macrophages expressing the macrophage galactose-type C-type lectin (MGL) during antigen-induced chronic granulation tissue formation

2005 • 11 citations