NF-κB in cancer: from innocent bystander to major culprit

The Hallmarks of Cancer

2000 • 27,569 citations

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Cancer statistics, 2000

2000 • 3,907 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Interleukin-1 polymorphisms associated with increased risk of gastric cancer

2000 • 2,355 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Helicobacter pylori and gastrointestinal tract adenocarcinomas

2002 • 1,775 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 • 1,282 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

Specific protection against breast cancers by cyclin D1 ablation

2001 • 930 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice

1996 • 839 citations

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

1997 • 824 citations

Aspirin Use and the Risk for Colorectal Cancer and Adenoma in Male Health Professionals

1994 • 804 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

1997 • 780 citations

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G₀/G₁-to-S-Phase Transition

1999 • 777 citations

The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development

2000 • 731 citations

Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.

1998 • 721 citations

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.

1997 • 717 citations

Increased risk of large-bowel cancer in Crohn's disease with colonic involvement

1990 • 703 citations

Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa

1998 • 696 citations

Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

1995 • 682 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Bcl10 Is Involved in t(1;14)(p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types

1999 • 666 citations

Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

1999 • 638 citations

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

1996 • 613 citations

Transcriptional Cross Talk between NF-κB and p53

1999 • 590 citations

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

2001 • 551 citations

Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.

1996 • 549 citations

Synergistic upregulation of metalloproteinase‐9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF‐κB

1998 • 500 citations

Sulindac Inhibits Activation of the NF-κB Pathway

1999 • 490 citations

IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development

2001 • 469 citations

The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

1990 • 469 citations

Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3

2000 • 451 citations

Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells

1997 • 413 citations

Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer.

1998 • 413 citations

Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-κB Signaling Pathway

2001 • 409 citations

B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50

1991 • 403 citations

The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis

2000 • 403 citations

A requirement for NF-kappa B activation in Bcr-Abl-mediated transformation

1998 • 397 citations

Signaling Pathways in Mammary Gland Development

2001 • 396 citations

HER-2/neu Blocks Tumor Necrosis Factor-induced Apoptosis via the Akt/NF-κB Pathway

2000 • 375 citations

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

1997 • 375 citations

Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8.

2000 • 372 citations

A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

1999 • 354 citations

Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene

1996 • 338 citations

The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators

1999 • 314 citations

Elevated cyclooxygenase-2 levels in Min mouse adenomas

1996 • 311 citations

Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells

2000 • 307 citations

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha

2001 • 294 citations

Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells

1999 • 285 citations

Suppression of NF-κB activity by sulfasalazine is mediated by direct inhibition of IκB kinases α and β

2000 • 285 citations

Modulation of NF-κB Activity and Apoptosis in Chronic Lymphocytic Leukemia B Cells

2000 • 278 citations

Nuclear factor-κB is upregulated in colorectal cancer

2001 • 266 citations

Her-2/neu overexpression induces NF-κB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IκB-α that can be inhibited by the tumor suppressor PTEN

2001 • 266 citations

NF-κB inhibition causes spontaneous apoptosis in Epstein–Barr virus-transformed lymphoblastoid cells

2000 • 258 citations

Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7, 12-dimethylbenz[a]anthracene-induced mammary cancer in rats

1996 • 248 citations

Hereditary Gastrointestinal Polyposis and Nonpolyposis Syndromes

1994 • 243 citations

RelB Cellular Regulation and Transcriptional Activity Are Regulated by p100

2002 • 213 citations

REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma

1996 • 212 citations

Inhibition of Interleukin-1-stimulated NF-κB RelA/p65 Phosphorylation by Mesalamine Is Accompanied by Decreased Transcriptional Activity

1999 • 209 citations

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

1999 • 204 citations

Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.

1996 • 193 citations

Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice

1993 • 193 citations

Methotrexate Suppresses NF-κB Activation Through Inhibition of IκBα Phosphorylation and Degradation

2001 • 189 citations

Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2

1997 • 178 citations

The nuclear factor kappa B (NF-κB): A potential therapeutic target for estrogen receptor negative breast cancers

2001 • 164 citations

Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

1999 • 160 citations

Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-kappaB in breast cancer.

2001 • 158 citations

The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily

1998 • 158 citations

Activation of NF-kappaB/Rel occurs early during neoplastic transformation of mammary cells

2000 • 158 citations

Aspirin protects against gastric cancer: Results of a case-control study from Moscow, Russia

1999 • 137 citations

Highly-expressed p100/p52 (NFKB2) sequesters other NF-kappa B-related proteins in the cytoplasm of human breast cancer cells.

1995 • 126 citations

Matrix Metalloproteinase 9 Expression Is Induced by Epstein-Barr Virus Latent Membrane Protein 1 C-Terminal Activation Regions 1 and 2

1999 • 121 citations

NF-κB Inhibits Apoptosis in Murine Mammary Epithelia

2000 • 112 citations

NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps

2001 • 106 citations

Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies

1994 • 105 citations

B‐CELL LYMPHOMA OF MALT TYPE: A REVIEW WITH SPECIAL EMPHASIS ON DIAGNOSTIC AND MANAGEMENT PROBLEMS OF LOW‐GRADE GASTRIC TUMOURS

1998 • 100 citations

Constitutive Expression of Bcl-3 in Thymocytes Increases the DNA Binding of NF-κB1 (p50) Homodimers In Vivo

1996 • 98 citations

P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts

2001 • 98 citations

Alterations at the rel locus in human lymphoma.

1991 • 93 citations

Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel

2001 • 89 citations

Molecular analysis of cutaneous B- and T-cell lymphomas

1995 • 82 citations

The Role of Epstein-Barr Virus in Neoplastic Transformation

2001 • 79 citations

The role of Rel/NF-κB proteins in viral oncogenesis and the regulation of viral transcription

1997 • 74 citations

Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice

1998 • 73 citations

Helicobacter pylori-induced Expression of Interleukin-8 and Cyclooxygenase-2 in AGS Gastric Epithelial Cells: Mediation by Nuclear Factor-κB

2001 • 70 citations

COX-2 and colon cancer

1998 • 69 citations

Identification of a tumor-associated mutant form of the NF-κB RelA gene with reduced DNA-binding and transactivating activities

1997 • 34 citations

Characterization of a novel promoter insertion in the c-rel locus.

1990 • 15 citations