Toll-like receptors mediate proliferation and survival of multiple myeloma cells

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2001 • 5,893 citations

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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A clinical staging system for multiple myeloma correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival

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International Staging System for Multiple Myeloma

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CpG Motifs in Bacterial DNA and Their Immune Effects

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Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

2002 • 1,919 citations

Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells

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Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

2002 • 1,214 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

Recognition of pathogen-associated molecular patterns by TLR family

2003 • 1,124 citations

mRNA Is an Endogenous Ligand for Toll-like Receptor 3

2004 • 994 citations

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

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Endogenous ligands of Toll-like receptors

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A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells

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Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses

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Toll‐like receptors, endogenous ligands, and systemic autoimmune disease

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The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells

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Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105

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The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B Cells

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A review of the cytokine network in multiple myeloma

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Signaling in B cells via Toll-like receptors

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Toll‐like receptor‐dependent activation of several human blood cell types by protamine‐condensed mRNA

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Interleukin-21 is a growth and survival factor for human myeloma cells

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IL-12p70-Dependent Th1 Induction by Human B Cells Requires Combined Activation with CD40 Ligand and CpG DNA

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ROLE OF INTERLEUKIN‐6 IN THE PATHOGENESIS OF MULTIPLE MYELOMA

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New insights into the pathophysiology of multiple myeloma

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Prophylactic antibiotics for the prevention of early infection in multiple myeloma

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Immunosuppression and infection in multiple myeloma.

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B-Cell Lymphomas Differ in their Responsiveness to CpG Oligodeoxynucleotides

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Novel therapeutic approaches for multiple myeloma

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Immunostimulatory oligodeoxynucleotides induce apoptosis of B cell chronic lymphocytic leukemia cells

2004 • 95 citations

The rise and fall of long‐lived humoral immunity: terminal differentiation of plasma cells in health and disease

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Plasma cell differentiation and multiple myeloma

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TNF and IL‐6 are potent growth factors for OH‐2, a novel human myeloma cell line

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Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4

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The Immune Response Modifier Resiquimod Mimics CD40-Induced B Cell Activation

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Frequent detection of the replicative form of TT virus DNA in peripheral blood mononuclear cells and bone marrow cells in cancer patients

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Lack of IL‐1 secretion from human myeloma cells highly purified by immunomagnetic separation

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Distinct Response of Human B Cell Subpopulations in Recognition of an Innate Immune Signal, CpG DNA

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Circulating clonal cells in multiple myeloma do not express CD34 mRNA, as measured by single‐cell and real‐time RT‐PCR assays

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Occurrence of dysregulated oncogenes in primary plasma cells representing consecutive stages of myeloma pathogenesis: indications for different disease entities

2003 • 28 citations

Heat shock up-regulates TLR9 expression in human B cells through activation of ERK and NF-κB signal pathways

2004 • 17 citations