CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

1991 • 3,869 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.

1992 • 3,047 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Inflammatory bowel disease: Etiology and pathogenesis

1998 • 2,095 citations

The Vienna classification of gastrointestinal epithelial neoplasia

2000 • 2,041 citations

World Health Organization classification of tumors

2000 • 1,998 citations

Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications

1983 • 1,856 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer

2000 • 580 citations

Hepatic Helicobacter species identified in bile and gallbladder tissue from chileans with chronic cholecystitis

1998 • 498 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

Control of intestinal inflammation by regulatory T cells

2001 • 496 citations

Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice

1994 • 485 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

Animal models of mucosal inflammation and their relation to human inflammatory bowel disease

1999 • 456 citations

Helicobacter hepaticusTriggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

1998 • 449 citations

Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10

1998 • 397 citations

Pathology and genetics of tumors of the digestive system

2001 • 365 citations

Phylogeny of the Defined Murine Microbiota: Altered Schaedler Flora

1999 • 360 citations

T cells in inflammatory bowel disease: protective and pathogenic roles

1995 • 359 citations

HELICOBACTER PYLORI AND GASTRIC CANCER

1993 • 357 citations

Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis

2002 • 324 citations

Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus

1997 • 318 citations

Regulatory T cells and inflammatory bowel disease

1999 • 270 citations

Chronic proliferative hepatitis in A/JCr mice associated with persistent Helicobacter hepaticus infection: a model of helicobacter-induced carcinogenesis

1996 • 229 citations

XII. IL-10-deficient (IL-10^−/−) mice and intestinal inflammation

2000 • 227 citations

Transforming growth factor beta1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis.

1999 • 221 citations

Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation

2000 • 209 citations

Recent Developments in the Immunology of Inflammatory Bowel Disease

2000 • 206 citations

Failure of Lymphopoiesis after Adoptive Transfer of NF-κB–Deficient Fetal Liver Cells

1997 • 193 citations

Inflammatory large bowel disease in immunodeficient mice naturally infected with Helicobacter hepaticus.

1996 • 184 citations

Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice

2001 • 180 citations

Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus

1996 • 175 citations

Identification of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay

1995 • 164 citations

Bacterial Infection Promotes Colon Tumorigenesis inApc^Min/+Mice

2001 • 160 citations

Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment

2000 • 153 citations

Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice.

2001 • 151 citations

T Helper 1 and T Helper 2 Cells Are Pathogenic in an Antigen-specific Model of Colitis

2002 • 142 citations

Helicobacter hepaticus-Induced Colitis in Interleukin-10-Deficient Mice: Cytokine Requirements for the Induction and Maintenance of Intestinal Inflammation

2001 • 140 citations

Interleukin-10 Inhibits Tumor Metastasis, Downregulates MHC Class I, and Enhances NK Lysis

1997 • 138 citations

Cutting Edge: Typhlocolitis in NF-κB-Deficient Mice

2001 • 134 citations

Diagnostic criteria for gastrointestinal carcinomas in Japan and Western countries: Proposal for a new classification system of gastrointestinal epithelial neoplasia

2000 • 126 citations

Spontaneous Inflammatory Bowel Disease in Multiple Mutant Mouse Lines: Association with Colonization by Helicobacter hepaticus

1998 • 117 citations

Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development

2001 • 94 citations

Impact of Helicobacter hepaticus Infection in B6C3F₁ Mice from Twelve National Toxicology Program Two-Year Carcinogenesis Studies

1998 • 93 citations

Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses.

2002 • 91 citations

Colitis-Inducing Potency of CD4+ T Cells in Immunodeficient, Adoptive Hosts Depends on Their State of Activation, IL-12 Responsiveness, and CD45RB Surface Phenotype

1999 • 87 citations

Cutting Edge: IL-10-Producing CD4+ T Cells Mediate Tumor Rejection

2002 • 80 citations

Fluorogenic PCR-Based Quantitative Detection of a Murine Pathogen, Helicobacter hepaticus

2001 • 78 citations

Differential Susceptibility to Hepatic Inflammation and Proliferation in AXB Recombinant Inbred Mice Chronically Infected with Helicobacter hepaticus

1999 • 77 citations

IL-7 Deficiency Prevents Development of a Non-T Cell Non-B Cell-Mediated Colitis

1998 • 68 citations

The pattern of cell proliferation in neoplastic and nonneoplastic lesions of ulcerative colitis

1996 • 68 citations

Natural CD4⁺ CD25⁺ regulatory T cells. Their role in the control of superantigen responses

2001 • 47 citations

Contributions of the T Cell Receptor–associated CD3γ–ITAM to Thymocyte Selection

2002 • 40 citations

Long-term colonization levels of Helicobacter hepaticus in the cecum of hepatitis-prone A/JCr mice are significantly lower than those in hepatitis-resistant C57BL/6 mice.

2001 • 39 citations