The p53 Tumor Suppressor Network Is a Key Responder to Microenvironmental Components of Chronic Inflammatory Stress

Inflammation and cancer

2002 • 14,174 citations

Surfing the p53 network

2000 • 6,487 citations

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

2004 • 3,161 citations

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

2003 • 1,851 citations

Radical causes of cancer

2003 • 1,611 citations

The causes and prevention of cancer.

1995 • 1,326 citations

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

2000 • 650 citations

Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

2000 • 643 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

2005 • 624 citations

Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease.

2000 • 475 citations

Identifying protein-binding sites from unaligned DNA fragments.

1989 • 471 citations

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

1996 • 455 citations

p53: 25 years after its discovery

2004 • 428 citations

Macrophage responses to hypoxia: relevance to disease mechanisms

1999 • 391 citations

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

2002 • 346 citations

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

1998 • 333 citations

Hypoxic Regulation of Inducible Nitric Oxide Synthase via Hypoxia Inducible Factor-1 in Cardiac Myocytes

2000 • 309 citations

Hypoxia Links ATR and p53 through Replication Arrest

2002 • 309 citations

Investigating hypoxic tumor physiology through gene expression patterns

2003 • 301 citations

Hypoxic inducible factor 1α, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide

2004 • 278 citations

High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID)

2005 • 274 citations

Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases

2000 • 247 citations

The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins

2004 • 247 citations

Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling

2004 • 214 citations

Nitric oxide in cancer and chemoprevention

2003 • 208 citations

Transcriptional repression mediated by the p53 tumour suppressor

2003 • 199 citations

The adaptive imbalance in base excision–repair enzymes generates microsatellite instability in chronic inflammation

2003 • 194 citations

Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression

2003 • 182 citations

Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice

1998 • 166 citations

Analyses of p53 Target Genes in the Human Genome by Bioinformatic and Microarray Approaches

2001 • 166 citations

Oxygen-Dependent and -Independent Regulation of HIF-1alpha

2002 • 149 citations

Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells.

2002 • 116 citations

The Role of Nitric Oxide (NO) in Stability Regulation of Hypoxia Inducible Factor-1α (HIF-1α)

2003 • 107 citations

Ribonucleotide reductases and radical reactions

1998 • 104 citations

Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells

2002 • 94 citations

Hydroxyurea Induces Site‐specific DNA Damage via Formation of Hydrogen Peroxide and Nitric Oxide

2001 • 93 citations

Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest

2003 • 90 citations

Hypoxia induces nitric oxide production in mouse microglia via p38 mitogen-activated protein kinase pathway

2002 • 86 citations

Tumor suppressor p53 represses transcription of RECQ4 helicase

2005 • 78 citations

Apoptotic Signaling Pathways Induced by Nitric Oxide in Human Lymphoblastoid Cells Expressing Wild-Type or Mutant p53

2004 • 74 citations

Ontologies: Formalising biological knowledge for bioinformatics

2003 • 62 citations

Tumor hypoxia and the cell cycle: implications for malignant progression and response to therapy.

1998 • 61 citations

p53-Mediated Apoptosis and Genomic Instability Diseases

2001 • 52 citations

Cell death and free radicals: A mechanism for hydroxyurea teratogenesis

1979 • 51 citations

Negative Regulation of Chk2 Expression by p53 Is Dependent on the CCAAT-binding Transcription Factor NF-Y

2004 • 47 citations

NO and transcriptional regulation: from signaling to death

2004 • 46 citations

Global Genechip Profiling to Identify Genes Responsive to p53-Induced Growth Arrest and Apoptosis in Human Lung Carcinoma Cells

2003 • 41 citations

Continuous monitoring of oxygen concentrations in several systems for cultivation of anaerobic bacteria

1996 • 41 citations

HIF-1α and p53 as Targets of NO in Affecting Cell Proliferation, Death and Adaptation

2004 • 36 citations

Depletion of deoxyribonucleoside triphosphate pools in tumor cells by nitric oxide

2004 • 33 citations

Quiescent S-phase cells as indicators of extreme physiological conditions in human tumor xenografts

1999 • 13 citations