Blocking NO synthesis: how, where and why?

Nitric oxide synthases: structure, function and inhibition

2001 • 3,508 citations

Nitric oxide and the immune response

2001 • 3,222 citations

Nitric oxide synthases: structure, function and inhibition

2001 • 2,499 citations

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

1992 • 2,138 citations

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

1995 • 2,075 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

1990 • 1,869 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Nitrosylation

2001 • 1,229 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

Nitric oxide in skeletal muscle

1994 • 972 citations

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy

1995 • 954 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo

1997 • 828 citations

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

2002 • 779 citations

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

2002 • 754 citations

Nitric Oxide as a Signaling Molecule in the Vascular System: An Overview

1999 • 754 citations

Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

1996 • 713 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Accelerated Atherosclerosis, Aortic Aneurysm Formation, and Ischemic Heart Disease in Apolipoprotein E/Endothelial Nitric Oxide Synthase Double-Knockout Mice

2001 • 609 citations

Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase

2001 • 596 citations

Novel Effects of Nitric Oxide

2001 • 584 citations

Protein-Protein Interactions

1954 • 574 citations

Role of nitric oxide in carcinogenesis and tumour progression

2001 • 552 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

1994 • 518 citations

Nitric oxide and bone

2001 • 503 citations

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits.

1994 • 501 citations

Inflammatory Regulators in Parkinson's Disease: iNOS, Lipocortin-1, and Cyclooxygenases-1 and -2

2000 • 482 citations

Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases

1999 • 469 citations

Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide

2002 • 469 citations

L-N6-(1-Iminoethyl)lysine: A Selective Inhibitor of Inducible Nitric Oxide Synthase

1994 • 464 citations

Biological significance of endogenous methylarginines that inhibit nitric oxide synthases

1999 • 456 citations

PIN: An Associated Protein Inhibitor of Neuronal Nitric Oxide Synthase

1996 • 454 citations

Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer.

1998 • 430 citations

Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase

1996 • 409 citations

Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69

2002 • 398 citations

Enhanced Electron Flux and Reduced Calmodulin Dissociation May Explain “Calcium-independent” eNOS Activation by Phosphorylation

2000 • 380 citations

NITRERGIC TRANSMISSION: NITRIC OXIDE AS A MEDIATOR OF NON‐ADRENERGIC, NON‐CHOLINERGIC NEURO‐EFFECTOR TRANSMISSION

1992 • 378 citations

Purification and properties of a new enzyme, N, N-dimethylarginine dimethylaminohydrolase, from rat kidney

1989 • 368 citations

Chapter 15 Nitric oxide in neurodegeneration

1998 • 366 citations

Nitric Oxide and Atherosclerosis

2001 • 363 citations

Nitric oxide and intestinal inflammation

2000 • 340 citations

Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice.

1998 • 339 citations

Expression of Inducible Nitric Oxide Synthase and Nitrotyrosine in Multiple Sclerosis Lesions

2001 • 318 citations

Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.

1994 • 318 citations

Neural roles for heme oxygenase: Contrasts to nitric oxide synthase

2001 • 298 citations

Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO

2001 • 298 citations

S -nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase

2002 • 297 citations

Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration

2002 • 242 citations

NO, nitrotyrosine, and cyclic GMP in signal transduction.

2001 • 239 citations

Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice

1999 • 232 citations

Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase.

2001 • 225 citations

Nitric Oxide-Dependent Penile Erection in Mice Lacking Neuronal Nitric Oxide Synthase

1996 • 224 citations

Expression and function of inducible nitric oxide synthase in neurons

2001 • 224 citations

Crystal Structures of Zinc-free and -bound Heme Domain of Human Inducible Nitric-oxide Synthase

1999 • 220 citations

Contribution of Nitric Oxide Synthases 1, 2, and 3 to Airway Hyperresponsiveness and Inflammation in a Murine Model of Asthma

1999 • 216 citations

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

2000 • 198 citations

Role of Nitric Oxide in Myocardial Preconditioning

2002 • 188 citations

Inducible Nitric Oxide Synthase Expression after Traumatic Brain Injury and Neuroprotection with Aminoguanidine Treatment in Rats

1998 • 186 citations

Inducible nitric oxide synthase expression in human cerebral infarcts

1999 • 184 citations

Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial

1999 • 177 citations

Nitric oxide inhibitors attenuate excitotoxicity in rat hippocampal slices

1992 • 174 citations

Critical role for nitric oxide signaling in cardiac and neuronal ischemic preconditioning and tolerance.

2001 • 171 citations

Modulation of mouse cardiac function in vivo by eNOS and ANP

2000 • 167 citations

Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase

1996 • 165 citations

The role of nitric oxide in nociception

2000 • 161 citations

Nitric oxide chemistry and cellular signaling

2001 • 161 citations

Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans

1997 • 156 citations

Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption

2000 • 156 citations

Effects of nitric oxide on the induction and differentiation of Th1 cells

1999 • 155 citations

Compartmentalised inducible nitric-oxide synthase activity in septic shock

2000 • 153 citations

Deletion of Exon 6 of the Neuronal Nitric Oxide Synthase Gene in Mice Results in Hypogonadism and Infertility

2002 • 151 citations

Neuronal and Glial Coexpression of Argininosuccinate Synthetase and Inducible Nitric Oxide Synthase in Alzheimer Disease

2001 • 144 citations

[3] Aconitases: A class of metalloproteins highly sensitive to nitric oxide synthesis

1996 • 142 citations

Potent and Selective Inhibition of Human Nitric Oxide Synthases

1994 • 136 citations

Nitric oxide and human skin blood flow responses to acetylcholine and ultraviolet light

1994 • 135 citations

Inducible nitric oxide synthase: a little bit of good in all of us

2000 • 127 citations

Nitric Oxide Trapping of Tyrosyl Radicals Generated during Prostaglandin Endoperoxide Synthase Turnover

1998 • 124 citations

Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission.

1996 • 119 citations

N5-(1-Imino-3-butenyl)-l-ornithine

1998 • 111 citations

Gene Expression Profiling of Mouse Bladder Inflammatory Responses to LPS, Substance P, and Antigen-Stimulation

2002 • 109 citations

Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo

1998 • 106 citations

Temporal Correlation Mapping Analysis of the Hemodynamic Penumbra in Mutant Mice Deficient in Endothelial Nitric Oxide Synthase Gene Expression

1996 • 103 citations

Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the ApcMin/+ mouse

2001 • 96 citations

Mechanistic Studies with Potent and Selective Inducible Nitric-oxide Synthase Dimerization Inhibitors

2002 • 95 citations

Endogenous nitric oxide in allergic airway disease

2000 • 94 citations

Regulation of Caspases by Nitric Oxide

2002 • 93 citations

Nitric oxide is proangiogenic in the retina and choroid*

2002 • 90 citations

[47] Nitration of unsaturated fatty acids by nitric oxide-derived reactive species

1999 • 87 citations

Long-Term Treatment With N ^ω -Nitro- <scp>l</scp> -Arginine Methyl Ester Causes Arteriosclerotic Coronary Lesions in Endothelial Nitric Oxide Synthase-Deficient Mice

2002 • 84 citations

Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis

2001 • 79 citations

Mouse Models of Nitric Oxide Synthase Deficiency

2000 • 78 citations

Synthesis and Biological Characterization of L-N⁶-(1-Iminoethyl)lysine 5-Tetrazole-amide, a Prodrug of a Selective iNOS Inhibitor

2002 • 75 citations

Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS

1999 • 74 citations

The dual mode of inhibition of calmodulin-dependent nitric-oxide synthase by antifungal imidazole agents

1993 • 71 citations

The Protective Role of Nitric Oxide in a Neurotoxicant- Induced Demyelinating Model

2002 • 70 citations

Nitric Oxide in Asthma

1999 • 64 citations

Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease

2001 • 63 citations

Inducible nitric oxide synthase (iNOS) activity promotes ischaemic skin flap survival

2001 • 61 citations

The Use of Aminoguanidine, a Selective iNOS Inhibitor, to Evaluate the Role of Nitric Oxide in the Development of Autoimmune Diabetes

1996 • 54 citations

Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice

2002 • 53 citations

Increased activity and expression of iNOS in human duodenal enterocytes from patients with celiac disease

2002 • 53 citations

ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia

2000 • 52 citations

Regulation of the nitric oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage

2001 • 48 citations

Increased Expression of Inducible Nitric Oxide Synthase in Circulating Monocytes from Patients with Active Inflammatory Bowel Disease

2002 • 46 citations

Interactive roles of superoxide and inducible nitric oxide synthase in rat intestinal injury provoked by non-steroidal anti-inflammatory drugs

2001 • 45 citations

Differential Sensitivity of the Tyrosyl Radical of Mouse Ribonucleotide Reductase to Nitric Oxide and Peroxynitrite

1998 • 41 citations

Expression of Inducible Nitric Oxide Synthase and Fas/Fas Ligand Correlates with the Incidence of Apoptotic Cell Death in Atheromatous Plaques of Human Coronary Arteries

2000 • 40 citations

The preferred source of arginine for high-output nitric oxide synthesis in blood vessels

2000 • 39 citations

3,4-Dihydro-1-isoquinolinamines: A novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency

2001 • 38 citations

Synthesis and Evaluation of Peptidomimetics as Selective Inhibitors and Active Site Probes of Nitric Oxide Synthases

2000 • 33 citations

Endothelial Nitric Oxide Synthase Expression in Tumor Vasculature Is Correlated with Malignancy in Human Supratentorial Astrocytic Tumors

1999 • 33 citations

Dimethylarginine dimethylaminohydrolase (DDAH) as a nerve‐injury‐associated molecule: mRNA localization in the rat brain and its coincident up‐regulation with neuronal NO synthase (nNOS) in axotomized motoneurons

1999 • 31 citations

Histochemical evidence for inducible nitric oxide synthase in advanced but non-ruptured human atherosclerotic carotid arteries.

2000 • 31 citations

NO in septic shock: Good, bad or ugly? Learning from iNOS knockouts

1996 • 28 citations

Cholinergic Contraction Is Altered in nNOS Knockouts

1999 • 26 citations

Implications for Isoform-selective Inhibitor Design Derived from the Binding Mode of Bulky Isothioureas to the Heme Domain of Endothelial Nitric-oxide Synthase

2001 • 25 citations

Structural Requirements for Inhibition of the Neuronal Nitric Oxide Synthase (NOS-I): 3D-QSAR Analysis of 4-Oxo- and 4-Amino-Pteridine-Based Inhibitors

2002 • 25 citations

Nitric oxide synthase is expressed in the lymphomononuclear cells of synovial fluid in patients with rheumatoid arthritis.

1999 • 24 citations

Functional effects of econazole on inducible nitric oxide synthase: production of a calmodulin‐dependent enzyme

1996 • 15 citations

Untitled

1998 • 12 citations

Purification and Assessment of Proteins Associated with Nitric Oxide Synthase

2002 • 1 citations