Role of Nitric Oxide in Myocardial Preconditioning

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Nitric Oxide: Pathophysiological Mechanisms

1995 • 876 citations

The Late Phase of Preconditioning

2000 • 753 citations

Nitric Oxide and Cardiac Function

1996 • 721 citations

Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia.

1993 • 629 citations

Preconditioning protects ischemic rabbit heart by protein kinase C activation

1994 • 603 citations

Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

1996 • 576 citations

Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms ε and η in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity

1997 • 491 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene

1999 • 389 citations

Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits

2000 • 389 citations

The Protective Effect of Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Mediated by Nitric Oxide Synthase

1997 • 316 citations

Nuclear Factor-κB Plays an Essential Role in the Late Phase of Ischemic Preconditioning in Conscious Rabbits

1999 • 302 citations

Reactions between Nitric Oxide, Superoxide, and Peroxynitrite: Footprints of Peroxynitrite in Vivo

1995 • 295 citations

The nitric oxide hypothesis of late preconditioning

1998 • 274 citations

Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning.

1994 • 272 citations

Isoform-Selective Activation of Protein Kinase C by Nitric Oxide in the Heart of Conscious Rabbits

1999 • 258 citations

Evidence That Late Preconditioning Against Myocardial Stunning in Conscious Rabbits Is Triggered by the Generation of Nitric Oxide

1997 • 255 citations

Nitric Oxide Synthase Is the Mediator of Late Preconditioning Against Myocardial Infarction in Conscious Rabbits

1998 • 254 citations

Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs.

1996 • 244 citations

PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits

1999 • 217 citations

Characterisation of the infarct-limiting effect of delayed preconditioning: timecourse and dose-dependency studies in rabbit myocardium

1997 • 214 citations

Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide.

1993 • 213 citations

Nitric Oxide Donors Induce Late Preconditioning Against Myocardial Stunning and Infarction in Conscious Rabbits via an Antioxidant-Sensitive Mechanism

1998 • 210 citations

Nitric Oxide Synthases: Gene Structure and Regulation

1995 • 189 citations

Demonstration of Selective Protein Kinase C–Dependent Activation of Src and Lck Tyrosine Kinases During Ischemic Preconditioning in Conscious Rabbits

1999 • 179 citations

Delayed Preconditioning-Mimetic Action of Nitroglycerin in Patients Undergoing Coronary Angioplasty

2001 • 166 citations

Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits

1997 • 151 citations

Biphasic response of cardiac NO synthase isoforms to ischemic preconditioning in conscious rabbits

2000 • 142 citations

Cellular Mechanisms in Ischemic Preconditioning: The Role of Adenosine and Protein Kinase C a

1994 • 134 citations

Time Course of Late Preconditioning Against Myocardial Stunning in Conscious Pigs

1996 • 132 citations

A ₁ or A ₃ Adenosine Receptors Induce Late Preconditioning Against Infarction in Conscious Rabbits by Different Mechanisms

2001 • 130 citations

Aldose Reductase Is an Obligatory Mediator of the Late Phase of Ischemic Preconditioning

2002 • 125 citations

The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase: an overview

1996 • 122 citations

Nitroglycerin Induces Late Preconditioning Against Myocardial Infarction in Conscious Rabbits Despite Development of Nitrate Tolerance

2001 • 103 citations

Increased protein synthesis is necessary for the development of late preconditioning against myocardial stunning

1999 • 91 citations

Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation

1996 • 90 citations

The Early and Late Phases of Ischemic Preconditioning

1997 • 85 citations

Ischemic Preconditioning Increases iNOS Transcript Levels in Conscious Rabbits via a Nitric Oxide-dependent Mechanism

1999 • 78 citations

Differential role of K_ATP channels in late preconditioning against myocardial stunning and infarction in rabbits

2000 • 66 citations

Nitroglycerin induces late preconditioning against myocardial stunning via a PKC-dependent pathway

1999 • 61 citations

Role of adenosine receptors in late preconditioning against myocardial stunning in conscious rabbits

1997 • 60 citations

Bifunctional Role of Protein Tyrosine Kinases in Late Preconditioning Against Myocardial Stunning in Conscious Rabbits

1999 • 48 citations

Myocardial Adaptation, Stress Proteins, and the Second Window of Protection

1996 • 44 citations