Reduction in asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease

“Mini-mental state”

1975 • 82,784 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Cerebral Blood Flow in Dementia

1975 • 3,133 citations

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

1992 • 2,138 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation

1998 • 507 citations

Bioenergetic and oxidative stress in neurodegenerative diseases

1995 • 365 citations

An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates

1988 • 349 citations

Brain S‐Adenosylmethionine Levels Are Severely Decreased in Alzheimer's Disease

1996 • 261 citations

Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine.

1990 • 258 citations

Reactive oxygen species and Alzheimer's disease

1997 • 228 citations

NG-Methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase

1993 • 178 citations

Relative sparing of nitric oxide synthase–containing neurons in the hippocampal formation in Alzheimer's disease

1992 • 175 citations

Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain

1997 • 175 citations

Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease

1999 • 166 citations

Determinants of neuronal vulnerability in neurodegenerative diseases

1998 • 115 citations

The nitric oxide hypothesis of brain aging

1997 • 113 citations

Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type

1985 • 110 citations

Increased number of NADPH-d-positive neurons within the substantia innominata in Alzheimer's disease

1995 • 46 citations

Isolation and Identification of Methylarginines from Bovine Brain

1992 • 28 citations