Compartmentalised inducible nitric-oxide synthase activity in septic shock

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study

1993 • 6,337 citations

A New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study

1993 • 5,263 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

Prognosis in Acute Organ-System Failure

1985 • 1,248 citations

Septic Shock in Humans

1990 • 1,170 citations

Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity.

1997 • 1,109 citations

Nitrite and nitrate determinations in plasma: a critical evaluation

1995 • 1,095 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Widespread tissue distribution, species distribution and changes in activity of Ca²⁺‐dependent and Ca²⁺‐independent nitric oxide synthases

1991 • 645 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway

1990 • 462 citations

Mechanisms of nitric oxide-related antimicrobial activity

1997 • 439 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

NO Inhibitions: Antimicrobial Properties of Nitric Oxide

1995 • 343 citations

Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia

1992 • 327 citations

Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria.

1996 • 310 citations

Bacterial infection induces nitric oxide synthase in human neutrophils.

1997 • 305 citations

N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin.

1992 • 252 citations

Differential Expression of iNOS and cNOS mRNA in Human Vascular Smooth Muscle Cells and Endothelial Cells under Normal and Inflammatory Conditions

1993 • 238 citations

Marked Induction of Calcium-Independent Nitric Oxide Synthase Activity after Focal Cerebral Ischemia

1995 • 220 citations

Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: role of TNF-alpha and IL-1-beta.

1994 • 192 citations

Expression of Inducible Nitric Oxide Synthase and Inflammatory Cytokines in Alveolar Macrophages of ARDS Following Sepsis

1998 • 111 citations

Association of microvascular leakage with induction of nitric oxide synthase: effects of nitric oxide synthase inhibitors in various organs

1995 • 101 citations

Nitric Oxide and Infection: Another View

1995 • 66 citations

Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats

1995 • 62 citations

Effect of bacterial lipopolysaccharide on function of rat small femoral arteries

1994 • 48 citations

Lipoteichoic Acid from Viridans Streptococci Induces the Production of Tumor Necrosis Factor and Nitric Oxide by Murine Macrophages

1996 • 40 citations

Pneumococci Stimulate the Production of the Inducible Nitric Oxide Synthase and Nitric Oxide by Murine Macrophages

1998 • 35 citations