Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

1992 • 837 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Selective inhibition of the inducible nitric oxide synthase by aminoguanidine

1993 • 734 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

1993 • 552 citations

Effects of a nitric oxide synthase inhibitor in humans with septic shock

1994 • 521 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

1991 • 386 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

1990 • 277 citations

Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine

1993 • 274 citations

Identification of N‐iminoethyl‐<scp>l</scp>‐ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells

1991 • 258 citations

Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L-thiocitrulline.

1994 • 220 citations

Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line

1993 • 204 citations

NG-Methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase

1993 • 178 citations

Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process.

1993 • 158 citations

Inhibition of nitric oxide formation by guanidines

1993 • 154 citations

Optical difference spectrophotometry as a probe of rat brain nitric oxide synthase heme-substrate interaction

1993 • 149 citations

Reversal of hyperdynamic response to continuous endotoxin administration by inhibition of NO synthesis

1992 • 143 citations

Aggression and emotional development.

1948 • 141 citations

Synthesis of L-Thiocitrulline, L-Homothiocitrulline, and S-Methyl-L-thiocitrulline: A New Class of Potent Nitric Oxide Synthase Inhibitors

1994 • 107 citations

Purification and Characterization of the Constitutive Nitric-Oxide Synthase from Human Placenta

1994 • 103 citations

NG-allyl- and NG-cyclopropyl-L-arginine: two novel inhibitors of macrophage nitric oxide synthase

1992 • 66 citations

Characterization of cell selectivity of two novel inhibitors of nitric oxide synthesis

1992 • 57 citations

Reversible inactivation of endothelial nitric oxide synthase byN^G-nitro-<scp>l</scp>-arginine

1993 • 31 citations

Preliminary Note on the Properties of s-Methyl Isothiourea Sulphate

1941 • 7 citations

Cardiovascular actions of a bis-isothiourea.

1958 • 3 citations