Chapter 15 Nitric oxide in neurodegeneration

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Neuronal NADPH diaphorase is a nitric oxide synthase.

1991 • 1,917 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.

1991 • 1,872 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

1991 • 1,364 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex

1988 • 1,244 citations

Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients.

1986 • 1,242 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

1994 • 1,052 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

[23] Oxidative chemistry of peroxynitrite

1994 • 981 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Nitric Oxide Inhibits Apoptosis by Preventing Increases in Caspase-3-like Activity via Two Distinct Mechanisms

1997 • 889 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

1997 • 809 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Poly(ADP-Ribose) in the Cellular Response to DNA Damage

1985 • 771 citations

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

1996 • 771 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

Selective Sparing of a Class of Striatal Neurons in Huntington's Disease

1985 • 767 citations

Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport

1996 • 719 citations

Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

1996 • 713 citations

Simulation of the diffusion and reaction of endogenously produced nitric oxide.

1994 • 699 citations

Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.

1994 • 658 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Synthesis of nitric oxide in CNS glial cells

1993 • 627 citations

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

1996 • 626 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

High nitric oxide production in human paranasal sinuses

1995 • 607 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains

1994 • 570 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation

1997 • 530 citations

Models of the diffusional spread of nitric oxide: Implications for neural nitric oxide signalling and its pharmacological properties

1994 • 517 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Nitric oxide neurotoxicity

1996 • 496 citations

In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases.

1993 • 484 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

The double-edged role of nitric oxide in brain function and superoxide-mediated injury.

1991 • 471 citations

Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase

1996 • 436 citations

Reduced Brain Edema and Infarction Volume in Mice Lacking the Neuronal Isoform of Nitric Oxide Synthase after Transient MCA Occlusion

1996 • 422 citations

Immunologic NO Synthase: Elevation in Severe AIDS Dementia and Induction by HIV-1 gp41

1996 • 422 citations

Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice

1996 • 413 citations

Localization of HIV‐1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry

1996 • 405 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Spectrum of human immunodeficiency virus–associated neocortical damage

1992 • 369 citations

Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite.

1997 • 368 citations

Nitric Oxide and Apoptosis: Another Paradigm for the Double-Edged Role of Nitric Oxide

1997 • 317 citations

Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia–reperfusion injury in the heart and skeletal muscle

1997 • 310 citations

Temporal trends in the incidence of HTV‐1‐related neurologic diseases

1994 • 305 citations

A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue

1996 • 304 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective

1995 • 301 citations

Molecular and biochemical features of poly (ADP-ribose) metabolism

1993 • 300 citations

The fine localization of dehydrogenases in the nervous system

1961 • 292 citations

Neurons Containing NADPH-Diaphorase Are Selectively Resistant to Quinolinate Toxicity

1986 • 292 citations

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

1985 • 290 citations

MPTP Toxicity: Implications for Research in Parkinson's Disease

1988 • 287 citations

New insights into the cause of Parkinson's disease

1992 • 272 citations

Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells

1995 • 270 citations

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione

1994 • 268 citations

Manganese Superoxide Dismutase Protects nNOS Neurons from NMDA and Nitric Oxide-Mediated Neurotoxicity

1998 • 266 citations

Nitric Oxide Induces Oxidative Damage in Addition to Deamination in Macrophage DNA

1995 • 258 citations

Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures

1994 • 251 citations

MPTP-induced parkinsonism in human and non-human primates--clinical and experimental aspects.

1984 • 250 citations

Inhibitors of Poly(Adenosine Diphosphate-Ribose) Synthesis: Effect on Other Metabolic Processes

1984 • 241 citations

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition

1997 • 238 citations

Neurological complications of HIV infection

1996 • 234 citations

The solitary active cells histochemical demonstration of damage-resistant nerve cells with a TPN-diaphorase reaction

1964 • 231 citations

Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome

1994 • 230 citations

Selective sparing of NADPH‐diaphorase–somatostatin–neuropeptide Y neurons in ischemic gerbil striatum

1990 • 218 citations

Structure and function of poly(ADP-ribose) polymerase

1994 • 206 citations

Chapter 31 Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration

1994 • 199 citations

Differential sparing of somatostatin‐neuropeptide y and cholinergic neurons following striatal excitotoxin lesions

1989 • 197 citations

Cortical dendritic pathology in human immunodeficiency virus encephalitis.

1992 • 194 citations

Relative sparing of nitric oxide synthase–containing neurons in the hippocampal formation in Alzheimer's disease

1992 • 175 citations

Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium

1993 • 171 citations

Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase

1996 • 165 citations

Quantitation of 8-Oxoguanine and Strand Breaks Produced by Four Oxidizing Agents

1997 • 163 citations

Neuroprotective Effects of Inhibiting Poly(ADP-Ribose) Synthetase on Focal Cerebral Ischemia in Rats

1997 • 158 citations

Oxygen-Dependent Regulation of Mitochondrial Energy Metabolism by Nitric Oxide

1995 • 156 citations

Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain.

1995 • 154 citations

Suppression of neuronal apoptosis by S-nitrosylation of caspases

1997 • 153 citations

Inducible Nitric-oxide Synthase and Nitric Oxide Production in Human Fetal Astrocytes and Microglia

1997 • 150 citations

Peroxynitrite and Nitric Oxide Donors Induce Neuronal Apoptosis by Eliciting Autocrine Excitotoxicity

1997 • 147 citations

Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse

1989 • 141 citations

Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase

1997 • 141 citations

Dual role of nitric oxide in focal cerebral ischemia

1994 • 141 citations

Nitric Oxide in Neuronal Degeneration

1996 • 140 citations

Cyclooxygenase‐2: an essential regulator of NO‐mediated apoptosis

1997 • 133 citations

Cultured striatal neurons containing NADPH-diaphorase or acetylcholinesterase are selectively resistant to injury by NMDA receptor agonists

1988 • 130 citations

AIDS Dementia Is Associated with Massive, Activated HIV-1 Infection and Concomitant Expression of Several Cytokines

1996 • 128 citations

ADP-ribosylation reactions

1995 • 127 citations

Nitric oxide inhibits DNA ligase activity: potential mechanisms for NO-mediated DNA damage

1996 • 126 citations

Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis

1997 • 119 citations

Poly(ADP‐Ribose) Synthetase Activation: An Early Indicator of Neurotoxic DNA Damage

1995 • 118 citations

Molecular Mechanisms of Nitric Oxide Actions in the Brain^a

1994 • 115 citations

Appearance of inducible nitric oxide synthase in the rat central nervous system after rabies virus infection and during experimental allergic encephalomyelitis but not after peripheral administration of endotoxin

1995 • 112 citations

Synaptic plasticity: A role for nitric oxide in LTP

1997 • 104 citations

Nitric oxide: inducer or suppressor of apoptosis?

1997 • 102 citations

Effects of Redox-Related Congeners of NO on Apoptosis and Caspase-3 Activity

1997 • 101 citations

Differential Susceptibility to Neurotoxicity Mediated by Neurotrophins and Neuronal Nitric Oxide Synthase

1997 • 97 citations

Parkinsonism‐inducing neurotoxin MPP⁺: Uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA

1992 • 94 citations

Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57Bl/6 mice

1996 • 84 citations

Protection by Inhibition of Poly (ADP-ribose) Synthetase Against Oxidant Injury in Cardiac MyoblastsIn Vitro

1997 • 76 citations

Relation of superoxide generation and lipid peroxidation to the inhibition of NADH-Q oxidoraductase by rotenone, piericidin A, and MPP+

1992 • 75 citations

Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri‐infarct zone during focal cerebral ischemia

1997 • 61 citations

Structural dependence of the inhibition of mitochondrial respiration and of NADH oxidase by 1-methyl-4-phenylpyridinium (MPP+) analogs and their energized accumulation by mitochondria.

1989 • 55 citations

Nitric Oxide Inhibits CPP32-like Activity under Redox Regulation

1997 • 54 citations

Preincubation with protein synthesis inhibitors protects cortical neurons against oxygen-glucose deprivation-induced death

1996 • 51 citations

Protection of rat spinal cord from ischemia with dextrorphan and cycloheximide: Effects on necrosis and apoptosis

1997 • 48 citations

Molecular Mechanisms of Apoptosis in HL-60 Cells Induced by a Nitric Oxide-Releasing Compound

1997 • 45 citations

Differential induction of apoptosis in Swiss 3T3 cells by nitric oxide and the nitrosonium cation

1997 • 45 citations

Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice

1996 • 41 citations

Chapter 14 Neurotoxic and Neuroprotective Roles of Nitric Oxide in Cerebral Ischaemia

1996 • 39 citations

The mapping of HIV-1 gpl60 epitopes required for interleukin-1 and tumor necrosis factor a production in glial cells

1995 • 33 citations

Complete inhibition of poly(ADP-ribose) polymerase activity prevents the recovery of C3H1OT1/2 cells from oxidative stress

1996 • 32 citations

Mitochondrial and metabolic toxicity of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine.

1987 • 31 citations

Oxygen-Dependent Fragmentation of Cellular DNA by Nitric Oxide

1997 • 29 citations

Influence of Poly(ADP-ribose) Synthesis Inhibitors on the Repair of Sublethal and Potentially Lethal Damage in γ-irradiated Mammalian Cells

1985 • 29 citations

Cloning and expression of a cDNA encoding human endothelium-derived relating factor/nitric oxide synthase.

1992 • 28 citations

Nitric Oxide Synthase Type II mRNA Stability Is Translation‐ and Transcription‐Dependent

1996 • 26 citations

Poly-(ADP-ribose) polymerase partially contributes to target cell death triggered by cytolytic T lymphocytes.

1992 • 22 citations

The kinetics and regulation of the induction of type II nitric oxide synthase and nitric oxide in human fetal glial cell cultures

1997 • 18 citations

21‐Aminosteroids Interact with the Dopamine Transporter to Protect Against 1‐Methyl‐4‐Phenylpyridinium‐Induced Neurotoxicity

1992 • 15 citations

Nitric oxide and cerebral ischemia.

1996 • 15 citations

Metabolic Effects of Poly(ADP-Ribose) Inhibitors

1985 • 1 citations