ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia

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NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices

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Middle Cerebral Artery Occlusion in the Rat by Intraluminal Suture

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Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

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Oxygen radical mechanisms of brain injury following ischemia and reperfusion

1991 • 657 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

1994 • 462 citations

Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice

1996 • 413 citations

Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles

1993 • 371 citations

The NOS Inhibitor, 7-Nitroindazole, Decreases Focal Infarct Volume but Not the Response to Topical Acetylcholine in Pial Vessels

1994 • 298 citations

Nitric oxide synthases: targets for therapeutic strategies in neurological diseases

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Nitric oxide: foe or friend to the injured brain?

1993 • 212 citations

Selective inhibitors of neuronal nitric oxide synthase – is no NOS really good NOS for the nervous system?

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Aminoguanidine Ameliorates and <scp>l</scp> -Arginine Worsens Brain Damage From Intraluminal Middle Cerebral Artery Occlusion

1996 • 184 citations

Mechanisms Involved in the Neuroprotective Activity of a Nitric Oxide Synthase Inhibitor During Focal Cerebral Ischemia

1993 • 171 citations

Role of nitric oxide in traumatic brain injury in the rat

1998 • 165 citations

Attenuated hippocampal damage after global cerebral ischemia in mice mutant in neuronal nitric oxide synthase

1996 • 165 citations

ARL 17477, a Potent and Selective Neuronal NOS Inhibitor Decreases Infarct Volume after Transient Middle Cerebral Artery Occlusion in Rats

1996 • 163 citations

Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome.

1994 • 144 citations

BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: A promising neuroprotective strategy

1999 • 128 citations

Reduction of the Neurological Deficit in Mice with Traumatic Brain Injury by Nitric Oxide Synthase Inhibitors

1996 • 100 citations

The antinociceptive effect of 1‐(2‐trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse

1995 • 98 citations

Striatal Malonate Lesions Are Attenuated in Neuronal Nitric Oxide Synthase Knockout Mice

1996 • 88 citations

Cerebroprotective Effect of the Nitric Oxide Synthase Inhibitors, 1-(2-Trifluoromethylphenyl) Imidazole and 7-Nitro Indazole, after Transient Focal Cerebral Ischemia in the Rat

1998 • 84 citations

Consecutive evaluation of nitric oxide production after transient cerebral ischemia in the rat hippocampus using in vivo brain microdialysis

1998 • 82 citations

enhances neuronal death following transient forebrain ischemia in gerbils

1992 • 81 citations

Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion

1995 • 76 citations

Effects of <scp>l</scp>-NAME and 7-NI on NOS Catalytic Activity and Behavioral Outcome After Traumatic Brain Injury in the Rat

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p53 from basic research to clinical applications.

1992 • 67 citations

LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia

2000 • 60 citations

Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia

1996 • 59 citations

Nitric oxide synthase inhibitorNG-nitro-l-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischemia in hyperglycemic rats

1995 • 55 citations

Endothelin-1 induced middle cerebral artery occlusion: pathological consequences and neuroprotective effects of MK801

1994 • 53 citations

Anti‐ischaemic efficacy of a nitric oxide synthase inhibitor and a N‐methyl‐<scp>d</scp>‐aspartate receptor antagonist in models of transient and permanent focal cerebral ischaemia

1994 • 53 citations

Nitric oxide synthase in cerebral ischemia

1995 • 50 citations

Synergistic Protective Effects of Antioxidant and Nitric Oxide Synthase Inhibitor in Transient Focal Ischemia

1999 • 48 citations

protects against ischaemia-induced increases in nitric oxide and hippocampal neuro-degeneration in the gerbil

1994 • 44 citations

Nitric Oxide Production in the CA1 Field of the Gerbil Hippocampus After Transient Forebrain Ischemia

1999 • 40 citations

Regional measurements of NO formedin vivoduring brain ischemia

1997 • 37 citations

A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat

1999 • 37 citations

Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia

1999 • 36 citations

Neuroprotective effects of the antioxidant LY231617 and NO synthase inhibitors in global cerebral ischaemia

1997 • 34 citations

Mechanisms of neuronal cell injury/death and targets for drug intervention

1997 • 26 citations

Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia

1999 • 23 citations

NG-nitro-l-arginine methyl ester protects against lipid peroxidation in the gerbil following cerebral ischaemia

1995 • 22 citations

Effect of AR-R 17477, a potent neuronal nitric oxide synthase inhibitor, on infarction volume resulting from permanent focal ischemia in rats

1999 • 19 citations

Nitric oxide: from basic research to clinical applications

1999 • 6 citations