Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Nitric Oxide Synthases: Properties and Catalytic Mechanism

1995 • 1,275 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Inducible nitric oxide synthase: what difference does it make?

1997 • 964 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo

1997 • 828 citations

Three-dimensional structure of NADPH–cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes

1997 • 722 citations

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate

1998 • 659 citations

Nitric Oxide Synthase in Models of Focal Ischemia

1997 • 659 citations

Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase

1998 • 610 citations

Nitric Oxide: A New Paradigm for Second Messengers

1995 • 566 citations

Complex synthetic chemical libraries indexed with molecular tags.

1993 • 444 citations

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.

1999 • 424 citations

The Structure of Nitric Oxide Synthase Oxygenase Domain and Inhibitor Complexes

1997 • 344 citations

Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors.

1995 • 308 citations

Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer.

1995 • 292 citations

Excitotoxicity and nitric oxide in parkinson's disease pathogenesis

1998 • 285 citations

Crystal Structures of Zinc-free and -bound Heme Domain of Human Inducible Nitric-oxide Synthase

1999 • 220 citations

The role of nitric oxide in articular cartilage breakdown in osteoarthritis

1998 • 220 citations

Dopamine D2‐type agonists protect mesencephalic neurons from glutamate neurotoxicity: Mechanisms of neuroprotective treatment against oxidative stress

1998 • 191 citations

Characterization of Heme-deficient Neuronal Nitric-oxide Synthase Reveals a Role for Heme in Subunit Dimerization and Binding of the Amino Acid Substrate and Tetrahydrobiopterin

1996 • 184 citations

Domain Swapping in Inducible Nitric-oxide Synthase

1998 • 179 citations

Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate‐liganded heme protein that hydroxylates L‐arginine to produce NO as a cellular signal

1996 • 178 citations

Nitric oxide and inflammatory joint diseases

1998 • 176 citations

Intracellular Assembly of Inducible NO Synthase Is Limited by Nitric Oxide-mediated Changes in Heme Insertion and Availability

1996 • 175 citations

Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization

1997 • 148 citations

Characterization of the Inducible Nitric Oxide Synthase Oxygenase Domain Identifies a 49 Amino Acid Segment Required for Subunit Dimerization and Tetrahydrobiopterin Interaction

1997 • 145 citations

The role of nitric oxide in multiple sclerosis

1997 • 143 citations

Neuronal Nitric Oxide Synthase

1995 • 133 citations

Role of nitric oxide in the circulatory failure and organ injury in a rodent model of Gram‐positive shock

1996 • 100 citations

Antifungal Imidazoles Block Assembly of Inducible NO Synthase into an Active Dimer

1999 • 87 citations

Physiological and Toxicological Actions of Nitric Oxide in the Central Nervous System

1995 • 85 citations

The Inhibition of the Constitutive Bovine Endothelial Nitric Oxide Synthase by Imidazole and Indazole Agents

1994 • 65 citations

Active-Site Structure Analysis of Recombinant Human Inducible Nitric Oxide Synthase Using Imidazole

1996 • 47 citations