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Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Induction of nitric oxide synthase in asthma

1993 • 852 citations

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

1993 • 671 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

1994 • 518 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Selected Treatment Strategies for Septic Shock Based on Proposed Mechanisms of Pathogenesis

1994 • 450 citations

Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle.

1992 • 444 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter.

1996 • 394 citations

Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.

1995 • 389 citations

Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat

1990 • 369 citations

Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.

1994 • 365 citations

Modulation of Nitrogen Oxide Synthesis In Vivo: NG-Monomethyl-L-Arginine Inhibits Endotoxin-Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage

1990 • 345 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat

1993 • 295 citations

Induction of Nitric Oxide Synthase in Human Chondrocytes

1993 • 286 citations

Inhibition of nitric oxide synthesis increases blood pressure in healthy humans

1993 • 278 citations

L-arginine pathway in the sepsis syndrome

1993 • 242 citations

Platelet adhesion to human vascular endothelium is modulated by constitutive and cytokine induced nitric oxide

1993 • 222 citations

Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock

1995 • 211 citations

Novel signal transduction pathway mediating endothelium‐dependent β‐adrenoceptor vasorelaxation in rat thoracic aorta

1992 • 181 citations

Nitric oxide and cardiovascular control

1993 • 178 citations

A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome

1993 • 155 citations

Inhibition of Nitric Oxide Synthesis Is Detrimental During Endotoxemia

1994 • 151 citations

Mapping of the Genes Encoding Human Inducible and Endothelial Nitric Oxide Synthase (NOS2 and NOS3) to the Pericentric Region of Chromosome 17 and to Chromosome 7, Respectively

1994 • 58 citations

NG-methyl-L-arginine, an inhibitor of nitric oxide formation, acts synergistically with dobutamine to improve cardiovascular performance in endotoxemic dogs

1994 • 40 citations

Effect of anti‐fungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase

1994 • 40 citations

Effects of hepatocellular mitogens on cytokine-induced nitric oxide synthesis in human hepatocytes

1996 • 24 citations

Molecular Genetic Analysis of the Duplication of Human Inducible Nitric Oxide Synthase (NOS2) Sequences

1995 • 21 citations

Changes in nitric oxide release in vivo in response to vasoactive substances

1996 • 20 citations

THE NITRIC OXIDE SYNTHASE INHIBITOR 546C88 PROMOTES THE RESOLUTION OF SHOCK IN PATIENTS WITH SEVERE SEPSIS

1998 • 14 citations