Nitric oxide and bone

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Bone Resorption by Osteoclasts

2000 • 3,797 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor

1992 • 1,063 citations

Methods in nitric oxide research

1996 • 826 citations

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

Sensitivity of osteocytes to biomechanical stress in vitro

1995 • 768 citations

Methods in Nitric Oxide Research

1997 • 726 citations

Evidence for nitric oxide‐mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients

1994 • 718 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

Chondrocyte apoptosis induced by nitric oxide.

1995 • 627 citations

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

1992 • 622 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress

1995 • 572 citations

A Molecular Redox Switch on p21

1997 • 488 citations

The Akt kinase signals directly to endothelial nitric oxide synthase

1999 • 469 citations

Parathyroid Hormone Stimulates TRANCE and Inhibits Osteoprotegerin Messenger Ribonucleic Acid Expression in Murine Bone Marrow Cultures: Correlation with Osteoclast-Like Cell Formation*

1999 • 443 citations

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.

1992 • 428 citations

Estrogen Increases Endothelial Nitric Oxide by a Receptor Mediated System

1995 • 403 citations

Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter.

1996 • 394 citations

Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides.

1995 • 389 citations

Apoptosis in rheumatoid arthritis synovium.

1995 • 378 citations

Nitric Oxide-stimulated Guanine Nucleotide Exchange on p21ras

1995 • 367 citations

Differential Activation of Mitogen-activated Protein Kinases by Nitric Oxide-related Species

1996 • 332 citations

Nitric Oxide Synthase Expression in Bone Cells

1998 • 319 citations

Modulation of adjuvant arthritis by endogenous nitric oxide

1993 • 316 citations

Osteoclastic inhibition: an action of nitric oxide not mediated by cyclic GMP.

1991 • 307 citations

Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients.

1996 • 285 citations

Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

1996 • 284 citations

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine

1992 • 254 citations

Nitric oxide: A cytokine-induced regulator of bone resorption

1995 • 247 citations

Osteoclast Differentiation Factor Mediates an Essential Signal for Bone Resorption Induced by 1α,25-Dihydroxyvitamin D3, Prostaglandin E2, or Parathyroid Hormone in the Microenvironment of Bone

1998 • 243 citations

Mechanical Strain Stimulates Nitric Oxide Production by Rapid Activation of Endothelial Nitric Oxide Synthase in Osteocytes

1999 • 241 citations

Defective Bone Formation and Anabolic Response to Exogenous Estrogen in Mice with Targeted Disruption of Endothelial Nitric Oxide Synthase**This study was supported by grants from the Arthritis Research Campaign (UK) and the Medical Research Council (UK).

2001 • 237 citations

Endothelial Nitric Oxide Synthase Gene-Deficient Mice Demonstrate Marked Retardation in Postnatal Bone Formation, Reduced Bone Volume, and Defects in Osteoblast Maturation and Activity

2001 • 236 citations

Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.

1995 • 222 citations

On the expression of nitric oxide synthase by human macrophages. Why no NO?

1995 • 218 citations

N‐Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats

1994 • 213 citations

Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts

1996 • 210 citations

Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase.

1994 • 207 citations

Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption.

1994 • 198 citations

Bone loss: Factors that regulate osteoclast differentiation - an update

2000 • 195 citations

Nitric oxide donor alleviates ovariectomy-induced bone loss

1996 • 191 citations

Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis

1997 • 189 citations

Increased nitric oxide levels in patients with rheumatoid arthritis.

1996 • 187 citations

Expression and functional role of nitric oxide synthase in osteoblast-like cells

1995 • 177 citations

Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium.

1996 • 176 citations

Nitric Oxide Response to Shear Stress by Human Bone Cell Cultures Is Endothelial Nitric Oxide Synthase Dependent

1998 • 175 citations

Cytokine-Induced Nitric Oxide Inhibits Bone Resorption by Inducing Apoptosis of Osteoclast Progenitors and Suppressing Osteoclast Activity

1997 • 167 citations

Formation of Multinucleated Cells that Respond to Osteotropic Hormones in Long Term Human Bone Marrow Cultures*

1987 • 164 citations

Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption

2000 • 156 citations

Expression of Nitric Oxide Synthase Isoforms in Bone and Bone Cell Cultures

1997 • 154 citations

v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1995 • 151 citations

The Biphasic Effects of Nitric Oxide in Primary Rat Osteoblasts Are cGMP Dependent

2000 • 143 citations

Evidence for a Pathogenic Role of Nitric Oxide in Inflammation-Induced Osteoporosis

1999 • 134 citations

Isolation and Chromosomal Localization of the Human Endothelial Nitric Oxide Synthase (NOS3) Gene

1994 • 133 citations

Organization of the bovine gene encoding the endothelial nitric oxide synthase

1994 • 124 citations

Inhibition of Cathepsin K by Nitric Oxide Donors: Evidence for the Formation of Mixed Disulfides and a Sulfenic Acid

1999 • 122 citations

Elevated nitric oxide production in rheumatoid arthritis: Detection using the fasting urinary nitrate:creatinine ratio

1996 • 120 citations

Nitric Oxide Acts in Conjunction with Proinflammatory Cytokines to Promote Cell Death in Osteoblasts

1997 • 118 citations

NITRIC OXIDE PRODUCTION IN CELLS DERIVED FROM THE HUMAN JOINT

1996 • 112 citations

Nitric oxide mediates interleukin-1-induced matrix degradation and basic fibroblast growth factor release in cultured rabbit articular chondrocytes: a possible mechanism of pathological neovascularization in arthritis.

1996 • 111 citations

Estrogen Upregulates Endothelial Constitutive Nitric Oxide Synthase Expression in Human Osteoblast-Like Cells

1998 • 107 citations

Cytokines Induce Nitric Oxide Production in Mouse Osteoblasts

1994 • 105 citations

Nitric oxide is a mediator of apoptosis in the rheumatoid joint

2000 • 101 citations

Reduction of interleukin‐17–induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin‐4

2000 • 100 citations

Comparison of the nitric oxide synthase inhibitors methylarginine and aminoguanidine as prophylactic and therapeutic agents in rat adjuvant arthritis.

1995 • 93 citations

Inflammation-Mediated Osteopenia in the Rat: A New Animal Model for Pathological Loss of Bone Mass^*

1984 • 92 citations

Nitric oxide as s‐nitrosoproteins in rheumatoid arthritis

1997 • 90 citations

Expression and functional role of nitric oxide synthase isoforms in human osteoblast-like cells

1999 • 89 citations

Mechanisms of cytokine induced bone resorption: role of nitric oxide, cyclic guanosine monophosphate, and prostaglandins

1996 • 83 citations

Reduced bone formation in patients with osteoporosis associated with inflammatory bowel disease

1993 • 80 citations

Nitric oxide synthesis and its regulation by rabbit synoviocytes.

1994 • 78 citations

Urinary nitrate excretion is increased in patients with rheumatoid arthritis and reduced by prednisolone.

1995 • 65 citations

The l-arginine

1993 • 59 citations

Developmental Regulation of Nitric Oxide Synthase Expression in Rat Skeletal Bone

1999 • 58 citations

Bone turnover in non-steroid treated rheumatoid arthritis.

1994 • 58 citations

Restoration of Ovariectomy-Induced Osteopenia by Nitroglycerin

2000 • 53 citations

Involvement of nitric oxide and biopterin in proinflammatory cytokine-induced apoptotic cell death in mouse osteoblastic cell line MC3T3-E1

1999 • 45 citations

Nitric oxide accelerates the ascorbic acid-induced osteoblastic differentiation of mouse stromal ST2 cells by stimulating the production of prostaglandin E2

2000 • 38 citations

Ca2+ or Phorbol Ester But Not Inflammatory Stimuli Elevate Inducible Nitric Oxide Synthase Messenger Ribonucleic Acid and Nitric Oxide (NO) Release in Avian Osteoclasts: Autocrine NO Mediates Ca2+-Inhibited Bone Resorption*

1997 • 36 citations

Protection against peroxynitrite dependent tyrosine nitration and alpha 1-antiproteinase inactivation by some anti-inflammatory drugs and by the antibiotic tetracycline.

1996 • 35 citations