Nitric oxide is proangiogenic in the retina and choroid*

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Linear Mixed Models for Longitudinal Data

1997 • 3,557 citations

Linear Mixed Models for Longitudinal Data

2000 • 2,599 citations

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

1995 • 2,075 citations

Oxygen-induced retinopathy in the mouse.

1994 • 1,564 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

1997 • 1,162 citations

Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization.

1995 • 1,021 citations

Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.

1997 • 924 citations

Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.

1994 • 858 citations

Roles of nitric oxide in tumor growth.

1995 • 791 citations

Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1.

1995 • 673 citations

Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.

1995 • 585 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

Vascular Endothelial Growth Factor Signals Endothelial Cell Production of Nitric Oxide and Prostacyclin through Flk-1/KDR Activation of c-Src

1999 • 481 citations

Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries

1993 • 448 citations

VEGF is major stimulator in model of choroidal neovascularization.

2000 • 430 citations

Role of Nitric Oxide in Angiogenesis and Tumor Progression in Head and Neck Cancer

1998 • 427 citations

Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide

2000 • 421 citations

Retinal and choroidal neovascularization

2000 • 386 citations

Transgenic Mice with Increased Expression of Vascular Endothelial Growth Factor in the Retina: A New Model of Intraretinal and Subretinal Neovascularization.

1998 • 367 citations

Blockade of Vascular Endothelial Cell Growth Factor Receptor Signaling Is Sufficient to Completely Prevent Retinal Neovascularization

2000 • 340 citations

Nitric Oxide Induces the Synthesis of Vascular Endothelial Growth Factor by Rat Vascular Smooth Muscle Cells

2000 • 326 citations

Targeted Disruption of the FGF2 Gene Does Not Prevent Choroidal Neovascularization in a Murine Model

1998 • 324 citations

Transforming growth factor-?1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma

2001 • 242 citations

Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair

1999 • 239 citations

Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO

1999 • 239 citations

Genetic heterogeneity of angiogenesis in mice

2000 • 216 citations

Production of angiogenic activity by human monocytes requires an L-arginine/nitric oxide-synthase-dependent effector mechanism.

1994 • 205 citations

Nitric Oxide Synthase Inhibition by NG-Nitro-l-Arginine Methyl Ester Inhibits Tumor-Induced Angiogenesis in Mammary Tumors

1999 • 173 citations

Dramatic Inhibition of Retinal and Choroidal Neovascularization by Oral Administration of a Kinase Inhibitor

1999 • 171 citations

Evidence that nitric oxide is an endogenous antiangiogenic mediator

1994 • 170 citations

Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors.

1998 • 161 citations

Inhibition of angiogenesis, tumour growth and metastasis by the NO‐releasing vasodilators, isosorbide mononitrate and dinitrate

1995 • 156 citations

Reduced severity of oxygen-induced retinopathy in eNOS-deficient mice.

2001 • 147 citations

Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1

1999 • 137 citations

The role of thrombospondin‐1 in tumor progression and angiogenesis

1996 • 124 citations

Molecular biology of natriuretic peptides and nitric oxide synthases

2001 • 121 citations

Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy

2001 • 112 citations

Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha.

1997 • 88 citations

Angiogenesis in breast cancer: The role of transforming growth factor ? and CD105

2001 • 86 citations

Transforming growth factor beta1 induces angiogenesis in vivo with a threshold pattern.

1996 • 85 citations

Nitric Oxide Induces Angiogenesis and Upregulates αvβ3 Integrin Expression on Endothelial Cells

2000 • 71 citations

Blockade of TGF-β by in vivo gene transfer of a soluble TGF-β type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis

2000 • 66 citations

Antiangiogenesis efficacy of nitric oxide donors

2000 • 41 citations

In vivo experimental evidence that the nitric oxide pathway is involved in the X-ray-induced antiangiogenicity

1996 • 37 citations

Nitric oxide synthase-II is expressed in severe corneal alkali burns and inhibits neovascularization.

1999 • 36 citations

Antiangiogenic effects of S-nitrosocaptopril crystals as a nitric oxide donor

2000 • 19 citations

Nitric oxide suppresses bFGF‐ and IL‐1‐alpha‐mediated but not VEGF₁₆₅‐mediated angiogenesis in natively vascularized mammalian tissue*

1998 • 15 citations