Crystal Structures of Zinc-free and -bound Heme Domain of Human Inducible Nitric-oxide Synthase

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Solvent content of protein crystals

1968 • 7,954 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Nitric Oxide Synthases: Properties and Catalytic Mechanism

1995 • 1,275 citations

Anatomy of protein pockets and cavities: Measurement of binding site geometry and implications for ligand design

1998 • 1,017 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Three-dimensional structure of NADPH–cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes

1997 • 722 citations

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate

1998 • 659 citations

Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase

1998 • 610 citations

The molecular surface package

1993 • 590 citations

Protein-protein interactions: A review of protein dimer structures

1995 • 559 citations

STRUCTURE-FUNCTION ASPECTS IN THE NITRIC OXIDE SYNTHASES

1997 • 534 citations

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.

1999 • 424 citations

Protein clefts in molecular recognition and function.

1996 • 412 citations

Methods in nitric oxide research

1997 • 290 citations

Morphology of protein–protein interfaces

1998 • 232 citations

The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.

1994 • 218 citations

Natural resistance and nitric oxide

1995 • 181 citations

Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate‐liganded heme protein that hydroxylates L‐arginine to produce NO as a cellular signal

1996 • 178 citations

Comparative Functioning of Dihydro- and Tetrahydropterins in Supporting Electron Transfer, Catalysis, and Subunit Dimerization in Inducible Nitric Oxide Synthase

1998 • 145 citations

Characterization of the Inducible Nitric Oxide Synthase Oxygenase Domain Identifies a 49 Amino Acid Segment Required for Subunit Dimerization and Tetrahydrobiopterin Interaction

1997 • 145 citations

Subunit Interactions of Endothelial Nitric-oxide Synthase

1997 • 141 citations

Design of isoform-selective inhibitors of nitric oxide synthase

1998 • 108 citations

Tetrahydrobiopterin Binding to Macrophage Inducible Nitric Oxide Synthase: Heme Spin Shift and Dimer Stabilization by the Potent Pterin Antagonist 4-Amino-Tetrahydrobiopterin

1997 • 97 citations

Cysteine 99 of Endothelial Nitric Oxide Synthase (NOS-III) Is Critical for Tetrahydrobiopterin-Dependent NOS-III Stability and Activity

1995 • 86 citations

Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.

1995 • 77 citations

NO Synthase Isozymes Have Distinct Substrate Binding Sites

1997 • 70 citations

The C331A Mutant of Neuronal Nitric-Oxide Synthase Is Defective in Arginine Binding

1998 • 66 citations

Domains of Macrophage NO Synthase Have Divergent Roles in Forming and Stabilizing the Active Dimeric Enzyme

1996 • 62 citations

Inhibition of Nitric Oxide Synthase Activity by Zn2+ Ion

1995 • 60 citations

Endothelial Nitric Oxide Synthase: Modulations of the Distal Heme Site Produced by Progressive N-Terminal Deletions

1997 • 55 citations

A Functional Role for Protein Cavities in Domain:Domain Motions

1996 • 50 citations

Structural Requirements for Human Inducible Nitric Oxide Synthase Substrates and Substrate Analogue Inhibitors

1998 • 49 citations

The Activation of eNOS by Copper Ion (Cu2) in Human Pulmonary Arterial Endothelial Cells (HPAEC)

1998 • 32 citations

Acetamidine Lysine Derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide Dihydrochloride: A Highly Selective Inhibitor of Human Inducible Nitric Oxide Synthase

1998 • 26 citations