Expression and function of inducible nitric oxide synthase in neurons

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 • 1,106 citations

Anti-inflammatory drugs and their mechanism of action

1998 • 741 citations

Inflammation and Stroke: Putative Role for Cytokines, Adhesion Molecules and iNOS in Brain Response to Ischemia

2000 • 653 citations

Synthesis of nitric oxide in CNS glial cells

1993 • 627 citations

Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1997 • 593 citations

Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide

1998 • 568 citations

Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells

1995 • 484 citations

Nitric oxide, mitochondria and neurological disease

1999 • 474 citations

Apoptosis and the Nervous System

2000 • 469 citations

Roles of Nuclear Factor κB in Neuronal Survival and Plasticity

2000 • 465 citations

Constitutive NF-kB Activity in Neurons

1994 • 400 citations

Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNSIn Vivo

1998 • 353 citations

Constitutive NF-kappa B activity in neurons.

1994 • 304 citations

Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS

1994 • 301 citations

Inducible nitric oxide synthase gene expression in the brain during systemic inflammation

1996 • 287 citations

Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease.

1996 • 285 citations

Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo.

2000 • 257 citations

Chronic Stress Induces the Expression of Inducible Nitric Oxide Synthase in Rat Brain Cortex

2000 • 234 citations

Inducible Nitric Oxide Synthase Up‐Regulation in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1999 • 224 citations

Peroxisome Proliferator-Activated Receptor-γ Ligands Reduce Neuronal Inducible Nitric Oxide Synthase Expression and Cell DeathIn Vivo

2000 • 218 citations

Induction of Nitric Oxide Synthase and Nitric Oxide‐Mediated Apoptosis in Neuronal PC12 Cells After Stimulation with Tumor Necrosis FActor‐α/Lipopolysaccharide

1998 • 201 citations

Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine

1997 • 197 citations

Inducible Nitric Oxide Synthase Expression after Traumatic Brain Injury and Neuroprotection with Aminoguanidine Treatment in Rats

1998 • 186 citations

Nitric Oxide Synthase in Reactive Astrocytes Adjacent to β-Amyloid Plaques

1997 • 183 citations

Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis

1997 • 169 citations

Inducible Nitric Oxide Synthase Expression in Cerebrovascular Smooth Muscle and Neutrophils after Traumatic Brain Injury in Immature Rats1

1996 • 169 citations

Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study

1996 • 157 citations

Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine

1994 • 157 citations

Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase

1999 • 156 citations

A Novel, Nerve Growth Factor-activated Pathway Involving Nitric Oxide, p53, and p21WAF1 Regulates Neuronal Differentiation of PC12 Cells

1997 • 152 citations

Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review

1999 • 141 citations

Nitric oxide synthase expression and role during cardiomyogenesis

1999 • 137 citations

Neuronal and inducible nitric oxide synthase and nitrotyrosine immunoreactivities in the cerebral cortex of the aging rat

1998 • 123 citations

Cyclo-Oxygenase-2 Inhibitors

2000 • 117 citations

Implication of Glutamate in the Expression of Inducible Nitric Oxide Synthase After Oxygen and Glucose Deprivation in Rat Forebrain Slices

2000 • 115 citations

Neuronal expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices

1998 • 115 citations

Inducible Nitric Oxide Synthase Immunoreactivity in the Alzheimer Disease Hippocampus: Association with Hirano Bodies, Neurofibrillary Tangles, and Senile Plaques

1999 • 114 citations

Distinct distribution and time-course changes in neuronal nitric oxide synthase and inducible NOS in the paraventricular nucleus following lipopolysaccharide injection

1999 • 106 citations

iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis

2000 • 95 citations

Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: Platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression

1999 • 94 citations

Human Immunodeficiency Virus-1–Infected Macrophages Induce Inducible Nitric Oxide Synthase and Nitric Oxide (NO) Production in Astrocytes: Astrocytic NO as a Possible Mediator of Neural Damage in Acquired Immunodeficiency Syndrome

1999 • 93 citations

Temporal Profiles and Cellular Sources of Three Nitric Oxide Synthase Isoforms in the Brain after Experimental Contusion

2000 • 90 citations

Spontaneous Expression of Inducible Nitric Oxide Synthase in the Hypothalamus and Other Brain Regions of Aging Rats¹

1998 • 85 citations

In Vivo Expression of Inducible Nitric Oxide Synthase in Cerebellar Neurons

1996 • 85 citations

Regulation of the Manganese Superoxide Dismutase and Inducible Nitric Oxide Synthase Gene in Rat Neuronal and Glial Cells

1996 • 76 citations

CD 14 mediates endotoxin induction of nitric oxide synthase in cultured brain glial cells

1996 • 75 citations

Both neuronal NO synthase and nitric oxide are required for PC12 cell differentiation: a cGMP independent pathway

1999 • 65 citations

Expression of monocyte chemoattractant protein (MCP-1) and nitric oxide synthase-2 following cerebral trauma

1998 • 64 citations

Expression of the inducible nitric oxide synthase in distinct cellular types after traumatic brain injury: an in situ hybridization and immunocytochemical study

2000 • 59 citations

Growth factor induction of nitric oxide synthase in rat pheochromocytoma cells

1997 • 56 citations

Chapter 18 Expression of nitric oxide synthase-2 in glia associated with CNS pathology

1998 • 54 citations

Temporal Profiles and Cellular Sources of Three Nitric Oxide Synthase Isoforms in the Brain after Experimental Contusion

2000 • 45 citations

NO synthase-II is transiently expressed in embryonic mouse olfactory receptor neurons

1997 • 44 citations

Tumor Necrosis Factor‐α and Phorbol 12‐Myristate 13‐Acetate Differentially Modulate Cytotoxic Effect of Nitric Oxide Generated by Serum Deprivation in Neuronal PC12 Cells

1999 • 42 citations

Colitis and interleukin 1beta up-regulate inducible nitric oxide synthase and superoxide dismutase in rat myenteric neurons

1996 • 42 citations

Spontaneous Expression of Inducible Nitric Oxide Synthase in the Hypothalamus and Other Brain Regions of Aging Rats

1998 • 41 citations

Nitric oxide synthase expression in cervical spinal cord in sporadic amyotrophic lateral sclerosis

1998 • 39 citations

Production of inducible nitric oxide is required for monocytic differentiation of u937 cells induced by vitamin e-succinate

1998 • 37 citations

Nitric oxide synthase induction in glial cells: Effect on neuronal survival

1993 • 36 citations

Induction of Neuronal and Inducible Nitric Oxide Synthase in the Motoneurons of Spinal Cord Following Transient Abdominal Aorta Occlusion in Rats

1999 • 35 citations

Retinoic acid-induced differentiation in a human neuroblastoma cell line is associated with an increase in nitric oxide synthesis

1998 • 31 citations

Regulation of inducible nitric oxide synthase expression in human glia: implications for inflammatory central nervous system diseases

1997 • 30 citations

HIV-1 Infection Induces Differentiation of Immature Neural Cells through Autocrine Tumor Necrosis Factor and Nitric Oxide Production

1999 • 28 citations

Induction of Adhesion/Differentiation of Human Neuroblastoma Cells by Tumour Necrosis Factor‐α Requires the Expression of an Inducible Nitric Oxide Synthase

1997 • 24 citations

Induction of calcium-independent nitric oxide synthase activity in cultured cerebellar granule neurons

1995 • 23 citations

TNF-α Mediates Inducible Nitric Oxide Synthase Expression in Human Neuroblastoma Cell Line by Cisplatin

1997 • 20 citations

Colchicine Differentially Induces the Expressions of Nitric Oxide Synthases in Central and Peripheral Catecholaminergic Neurons

1998 • 19 citations

Nitric Oxide Underlies the Differentiation of PC 12 Cells Induced by Depolarization with High KCl

2000 • 19 citations

Lipopolysaccharide-induced nitric oxide synthase activity in cultured cerebellar granule neurons

1996 • 16 citations

Role of inducible nitric oxide synthase (iNOS) and peroxynitrite in gut inflammation

1995 • 14 citations

Nitric oxide synthase expression in human neuroblastoma cell line induced by cytokines

1996 • 14 citations

Selective expression of the NOS II isoform during mouse vestibulocochlear receptorgenesis

1999 • 13 citations

Induction of iNOS mRNA by interferon-gamma in epithelial cells is associated with growth arrest and differentiation

1996 • 10 citations

The effect of age and injury on the expression of inducible nitric oxide synthase in facial motor neurons in F344 rats

1999 • 8 citations