Nitric Oxide Trapping of Tyrosyl Radicals Generated during Prostaglandin Endoperoxide Synthase Turnover

Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

1996 • 1,987 citations

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1994 • 1,263 citations

Peroxidases in chemistry and biology

1990 • 1,039 citations

Prostaglandin Endoperoxide H Synthases-1 and -2

1996 • 721 citations

Prostaglandin endoperoxide synthase: structure and catalysis

1991 • 607 citations

Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular glands

1972 • 362 citations

Prostaglandin biosynthesis can be triggered by lipid peroxides

1979 • 357 citations

Higher oxidation states of prostaglandin H synthase

1988 • 284 citations

Requirements for hydroperoxide by the cyclooxygenase and peroxidase activities of prostaglandin H synthase

1983 • 277 citations

Higher oxidation states of prostaglandin H synthase

1988 • 254 citations

Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis

1990 • 229 citations

Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages.

1994 • 187 citations

Prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Inactivation and activation by heme and other metalloporphyrins.

1978 • 167 citations

Nitric Oxide Trapping of the Tyrosyl Radical of Prostaglandin H Synthase-2 Leads to Tyrosine Iminoxyl Radical and Nitrotyrosine Formation

1997 • 166 citations

Nitric oxide rapidly scavenges tyrosine and tryptophan radicals

1995 • 150 citations

Spectroscopic Evidence for Reaction of Prostaglandin H Synthase-1 Tyrosyl Radical with Arachidonic Acid

1995 • 134 citations

Interaction Between Nitric Oxide and Prostaglandin H Synthase

1994 • 132 citations

Essential histidines of prostaglandin endoperoxide synthase. His-309 is involved in heme binding.

1991 • 115 citations

Reactions of nitric oxide with phenolic antioxidants and phenoxyl radicals

1993 • 105 citations

Inhibition of Ribonucleotide Reductase by Nitric Oxide Derived from Thionitrites: Reversible Modifications of Both Subunits

1995 • 99 citations

Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom.

1984 • 98 citations

Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis.

1991 • 96 citations

Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis.

1994 • 95 citations

Spectral analysis of the protein-derived tyrosyl radicals from prostaglandin H synthase.

1992 • 82 citations

Nitric Oxide: A Prostaglandin H Synthase 1 and 2 Reducing Cosubstrate That Does Not Stimulate Cyclooxygenase Activity or Prostaglandin H Synthase Expression in Murine Macrophages

1996 • 66 citations

NO Interacts with the Tyrosine Radical Y_D^• of Photosystem II To Form an Iminoxyl Radical

1997 • 62 citations

Reversible Binding of Nitric Oxide to Tyrosyl Radicals in Photosystem II. Nitric Oxide Quenches Formation of the S3 EPR Signal Species in Acetate-Inhibited Photosystem II^†

1996 • 50 citations

Prostaglandin endoperoxide synthase substituted with manganese protoporphyrin IX. Formation of a higher oxidation state and its relation to cyclooxygenase reaction.

1992 • 42 citations

[52] Preparation and proteolytic cleavage of apoprostaglandin endoperoxide synthase

1990 • 34 citations

An Examination of the Source of the Tyrosyl Radical in Ovine Prostaglandin Endoperoxide Synthase-1

1995 • 33 citations

Nitric oxide reactions with antioxidants in model systems: sterically hindered phenols and α-tocopherol in sodium dodecyl sulfate (SDS) micelles

1993 • 30 citations

Reactions of Prostaglandin Endoperoxide Synthase and Its Compound I with Hydroperoxides

1996 • 27 citations