NITRERGIC TRANSMISSION: NITRIC OXIDE AS A MEDIATOR OF NON‐ADRENERGIC, NON‐CHOLINERGIC NEURO‐EFFECTOR TRANSMISSION

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Role of endothelium in responses of vascular smooth muscle.

1983 • 1,975 citations

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

1990 • 1,869 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Peptidergic neurones

1980 • 1,523 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

1988 • 1,379 citations

Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

1985 • 1,266 citations

Biosynthesis of nitric oxide from l-arginine

1989 • 1,220 citations

Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter

1990 • 1,012 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase

1987 • 896 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

A specific inhibitor of nitric oxide formation from <scp>l</scp>‐arginine attenuates endothelium‐dependent relaxation

1989 • 862 citations

Textbook of Pharmacology.

1980 • 857 citations

Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle

1990 • 854 citations

Cyclic guanosine monophosphate as a mediator of vasodilation.

1986 • 811 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

<scp>l</scp>‐N^G‐nitro arginine (<scp>l</scp>‐NOARG), a novel, <scp>l</scp>‐arginine‐reversible inhibitor of endothelium‐dependent vasodilatation in vitro

1990 • 769 citations

Control of coronary vascular tone by nitric oxide.

1990 • 713 citations

The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation

1985 • 685 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Nitric oxide as a neuronal messenger

1991 • 638 citations

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells

1989 • 612 citations

Coexistence of peptides and classical neurotransmitters

1983 • 559 citations

The Endothelium: Modulator of Cardiovascular Function

2020 • 543 citations

The Innervation of the Pelvic and adjoining Viscera

1895 • 538 citations

Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid

1991 • 530 citations

Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.

1981 • 527 citations

Calcium‐dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin

1990 • 507 citations

The enteric nervous system

1988 • 449 citations

Control of regional blood flow by endothelium-derived nitric oxide.

1990 • 447 citations

Identification of arginine as a precursor of endothelium-derived relaxing factor.

1988 • 407 citations

Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.

1986 • 397 citations

Nitric oxide and vasoactive intestinal polypeptide mediate non-adrenergic, non-cholinergic inhibitory transmission to smooth muscle of the rat gastric fundus

1990 • 397 citations

Arginine is a physiological precursor of endothelium-derived nitric oxide

1988 • 392 citations

Review lecture. Neurotransmitters and trophic factors in the autonomic nervous system.

1981 • 368 citations

The rat anococcygeus muscle and its response to nerve stimulation and to some drugs

1972 • 365 citations

Motility of the Digestive Tract.

1983 • 319 citations

Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite

1981 • 318 citations

The effects of L‐arginine and N^G‐monomethyl L‐arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation

1989 • 313 citations

Nω-nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation

1990 • 310 citations

Evidence that part of the NANC relaxant response of guinea‐pig trachea to electrical field stimulation is mediated by nitric oxide

1991 • 300 citations

Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries.

1986 • 295 citations

The inhibitory innervation of the taenia of the guinea‐pig caecum

1966 • 293 citations

Regulation of the Release of Coexisting Neurotransmitters

1988 • 283 citations

Biosynthesis of endothelium-derived relaxing factor: A cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase

1989 • 271 citations

NG-nitro-L-arginine (N5-[imino(nitroamino)methyl]-L-ornithine) impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from l-arginine

1990 • 269 citations

Cyclic GMP and mechanisms of vasodilation

1989 • 260 citations

Anoxia and endothelium‐dependent reactivity of the canine femoral artery.

1983 • 259 citations

The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation

1989 • 254 citations

Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain

1990 • 252 citations

Release of nitric oxide upon stimulation of nonadrenergic noncholinergic nerves in the rat gastric fundus.

1991 • 245 citations

Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands

1989 • 238 citations

Neuropeptide Y as an autonomic neurotransmitter

1988 • 234 citations

<scp>l</scp>‐N^G‐nitro arginine inhibits non‐adrenergic, non‐cholinergic relaxations of guinea‐pig isolated tracheal smooth muscle

1990 • 230 citations

Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation.

1988 • 229 citations

Polypeptide-Containing Neurons in Airway Smooth Muscle

1987 • 227 citations

Mechanism of action of some inhibitors of endothelium-derived relaxing factor.

1986 • 218 citations

Kinetic characteristics of nitric oxide synthase from rat brain

1990 • 210 citations

Primary biliary cirrhosis: Paradigm or paradox for autoimmunity

1991 • 204 citations

<scp>l</scp>‐N^G‐monomethyl arginine and <scp>l</scp>‐N^G‐nitro arginine inhibit non‐adrenergic, non‐cholinergic relaxation of the mouse anococcygeus muscle

1990 • 201 citations

Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium

1989 • 191 citations

EVIDENCE FOR A ROLE OF NITRIC OXIDE IN THE NEUROTRANSMITTER SYSTEM MEDIATING RELAXATION OF THE RAT ANOCOCCYGEUS MUSCLEC

1989 • 190 citations

Non-adrenergic non-cholinergic relaxation mediated by nitric oxide in the canine ileocolonic junction

1990 • 185 citations

Possible role of nitric oxide in transmitting information from vasodilator nerve to cerebroarterial muscle

1990 • 180 citations

Enzymatic formation of nitrogen oxides from L-arginine in bovine brain cytosol

1989 • 160 citations

Messenger molecules in the cerebellum

1990 • 158 citations

Endothelium-derived relaxing factor

1989 • 149 citations

Nitric oxide synthesis in endothelial cytosol: Evidence for a calcium-dependent and a calcium-independent mechanism

1989 • 148 citations

Nitric oxide as an endogenous modulator of cholinergic neurotransmission in guinea-pig airways

1991 • 146 citations

Blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation of rabbit aorta by certain ferrous hemoproteins.

1985 • 145 citations

Production of endothelium derived relaxant factor is dependent on oxidative phosphorylation and extracellular calcium

1986 • 143 citations

Peripheral GABAergic mechanisms

1985 • 141 citations

Role of Nitric Oxide in Non-Adrenergic, Non-Cholinergic Nerve-Mediated Relaxation in Dog Duodenal Longitudinal Muscle Strips

1990 • 141 citations

Evidence that cyclic guanosine monophosphate (cGMP) mediates endothelium-dependent relaxation

1985 • 131 citations

Evidence for nitric oxide as mediator of non‐adrenergic, non‐cholinergic relaxations induced by ATP and GABA in the canine gut

1991 • 124 citations

Mechanisms of endothelium-dependent vascular smooth muscle relaxation

1985 • 115 citations

The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve‐evoked relaxation of human cavernosal smooth muscle

1991 • 114 citations

Endothelium-derived nitric oxide relaxes nonvascular smooth muscle

1989 • 111 citations

Essential role of nitric oxide in descending inhibition in the rat proximal colon

1990 • 111 citations

Modification by L-NG-monomethyl arginine (L-NMMA) of the response to nerve stimulation in isolated dog mesenteric and cerebral arteries.

1990 • 110 citations

Vasoactive intestinal peptide. Relaxant neurotransmitter in tenia coli of the guinea pig.

1985 • 109 citations

Cyclic GMP mediates neurogenic relaxation in the bovine retractor penis muscle

1984 • 108 citations

The role of nitric oxide in inhibitory non‐adrenergic non‐cholinergic neurotransmission in the canine lower oesophageal sphincter

1991 • 107 citations

Vasoactive intestinal peptide

1985 • 106 citations

Stimulus-Secretion Coupling in Vascular Endothelial Cells

1990 • 104 citations

cGMP: The wayward child of the cyclic nucleotide family

1991 • 103 citations

Effects of ω‐conotoxin GVIA on autonomic neuroeffector transmission in various tissues

1990 • 102 citations

L‐N^G‐nitro arginine inhibits non‐adrenergic, non‐cholinergic relaxation of human isolated corpus cavernosum

1991 • 99 citations

Bioassay of nitric oxide released upon stimulation of non‐adrenergic non‐cholinergic nerves in the canine ileocolonic junction

1991 • 98 citations

L‐N^G‐nitro‐arginine and its methyl ester are potent inhibitors of non‐adrenergic, non‐cholinergic transmission in the rat anococcygeus

1990 • 97 citations

Modulation of autonomic neuroeffector transmission by nitric oxide in guinea pig ileum

1990 • 94 citations

Non‐adrenergic, non‐cholinergic nerve‐mediated relaxation of rabbit urethra is caused by nitric oxide

1991 • 89 citations

The effects of pyrogallol and hydroquinone on the response to NANC nerve stimulation in the rat anococcygeus and the bovine retractor penis muscles

1990 • 89 citations

Nitric Oxide Mediates the Neurogenic Vasodilation of Bovine Cerebral Arteries

1991 • 88 citations

Evidence that nitric oxide participates in non-adrenergic inhibitory transmission to intestinal muscle in the guinea-pig

1991 • 86 citations

Relaxation of sheep cerebral arteries by vasoactive intestinal polypeptide and neurogenic stimulation: inhibition by <scp>l</scp>‐N^G‐monomethyl arginine in endothelium‐denuded vessels

1991 • 82 citations

Influence of haemoglobin and erythrocytes on the effects of EDRF, a smooth muscle inhibitory factor, and nitric oxide on vascular and non‐vascular smooth muscle

1988 • 81 citations

Evidence against vasoactive intestinal polypeptide being the non-adrenergic, non-cholinergic inhibitory transmitter released from nerves supplying the smooth muscle of the guinea-pig taenia coli

1980 • 80 citations

Relaxation of sheep urethral muscle induced by electrical stimulation of nerves: involvement of nitric oxide

1991 • 79 citations

The role of the <scp>l</scp>‐arginine‐nitric oxide pathway in relaxation of the opossum lower oesophageal sphincter

1991 • 78 citations

Effects of NG-monomethyl-L-arginine on field stimulation-induced decreases in cytosolic Ca2+ levels and relaxation in the rat anococcygeus muscle

1989 • 77 citations

Effects of N^G‐substituted analogues of <scp>l</scp>‐arginine on NANC relaxation of the rat anococcygeus and bovine retractor penis muscles and the bovine penile artery

1991 • 73 citations

NG-Amino-L-arginine: A new potent antagonist of L-arginine-mediated endothelium-dependent relaxation

1990 • 71 citations

Inhibitory effects of L-NG-nitro-arginine on the synthesis of EDRF and the cerebroarterial response to vasodilator nerve stimulation

1990 • 71 citations

Effect of N^G‐monomethyl <scp>l</scp>‐arginine (<scp>l</scp>‐NMMA) and N^G‐nitro <scp>l</scp>‐arginine (<scp>l</scp>‐NOARG) on non‐adrenergic non‐cholinergic relaxation in the circular muscle of the human ileum

1991 • 67 citations

Coronary vasodilatation induced by endotoxin in the rabbit isolated perfused heart is nitric oxide‐dependent and inhibited by dexamethasone

1991 • 66 citations

Block of some non‐adrenergic inhibitory responses of smooth muscle by a substance from haemolysed erythrocytes

1982 • 66 citations

Oxyhaemoglobin blocks non-adrenergic non-cholinergic inhibition in the bovine retractor penis muscle

1982 • 66 citations

Is arginine a physiological precursor of endothelium-derived nitric oxide?

1988 • 66 citations

Role of endothelium-formed nitric oxide on vascular responses

1990 • 66 citations

Relaxant responses to transmural stimulation and nicotine of dog and monkey cerebral arteries

1982 • 65 citations

Novel Peripheral Neurotransmitters

1991 • 62 citations

The spinal origin of the motor and inhibitory innervation of the rat anococcygeus muscles

1973 • 59 citations

Bradykinin induces elevations of cytosolic calcium through mobilisation of intracellular and extracellular pools in bovine aortic endothelial cells

1991 • 58 citations

The non-adrenergic non-cholinergic nervous system.

1986 • 57 citations

Hemolysate Inhibits Cerebral Artery Relaxation

1988 • 55 citations

Endothelium-derived relaxing factor release associated with increased endothelial cell inositol trisphosphate and intracellular calcium

1988 • 54 citations

Analysis of the potentiating action of NG-nitro-l-arginine on the contraction of the dog temporal artery elicited by transmural stimulation of noradrenergic nerves

1991 • 51 citations

The effect of immunosympathectomy and of 6‐hydroxydopamine on the responses of the rat anococcygeus to nerve stimulation and to some drugs

1973 • 51 citations

INHIBITION OF ENDOTHELIAL NITRIC OXIDE BIOSYNTHESIS BY N‐NITRO‐l‐ARGININE

1990 • 51 citations

Neurogenic vasodilatation in isolated bovine and canine penile arteries.

1983 • 49 citations

Endothelial nitric oxide attenuates vasoconstrictor responses to nerve stimulation and noradrenaline in the rat tail artery

1991 • 49 citations

CP‐93,129, a potent and selective 5‐HT_1B receptor agonist blocks neurogenic plasma extravasation within rat but not guinea‐pig dura mater

1991 • 46 citations

Suppression of the Excitatory Adrenergic Neurotransmission; a Possible Role of Cholinergic Nerves in the Retractor Penis Muscle

1977 • 46 citations

N‐methylhydroxylamine inhibits and M&amp;B 22948 potentiates relaxations of the mouse anococcygeus to non‐adrenergic, non‐cholinergic field stimulation and to nitrovasodilator drugs

1989 • 41 citations

NON‐ADRENERGIC, NON‐CHOLINERGIC INNERVATION IN MONKEY AND HUMAN CEREBRAL ARTERIES

1981 • 38 citations

Nitric oxide requirement for vasomotor nerve‐induced vasodilation and modulation of resting blood flow in muscle microcirculation

1991 • 38 citations

A comparison of haemoglobin and erythrocytes as inhibitors of smooth muscle relaxation by the NANC transmitter in the BRP and rat anococcygeus and by EDRF in the rabbit aortic strip

1989 • 36 citations

Effects of metabolic inhibitors on endothelium‐dependent and endothelium‐independent vasodilatation of rat and rabbit aorta

1991 • 36 citations

Role of nitric oxide and cyclic GMP as mediators of endothelium-independent neurogenic relaxation in bovine mesenteric artery.

1991 • 35 citations

The effects of adenosine triphosphate (ATP) and related purines on human isolated subcutaneous and omental resistance arteries

1991 • 35 citations

ACTIVATION OF NORADRENERGIC AND NITRERGIC MECHANISMS IN THE RAT ANOCOCCYGEUS MUSCLE BY NICOTINE

1992 • 35 citations

GABA_A receptor‐mediated stimulation of non‐adrenergic non‐cholinergic neurones in the dog ileocolonic junction

1990 • 35 citations

Prejunctional inhibition of non-adrenergic non-cholinergic transmission in the rat anococcygeus muscle

1989 • 34 citations

RESPONSES OF THE ISOLATED ANOCOCCYGEUS MUSCLE OF THE MOUSE TO DRUGS AND TO FIELD STIMULATION

1981 • 34 citations

ENDOTHELIUM‐DERIVED RELAXING FACTOR RELEASED FROM CULTURED CELLS: DIFFERENTIATION FROM NITRIC OXIDE

1988 • 34 citations

Inhibition of inositol 1,4,5‐trisphosphate formation by cyclic GMP in cultured aortic endothelial cells of the pig

1991 • 31 citations

Cyclic Nucleotide Content of the Rat Anococcygeus During Relaxations Induced by Drugs or by Non-adrenergic, Non-cholinergic Field Stimulation

1991 • 29 citations

Novel autonomic neurotransmitters and intestinal function

1989 • 28 citations

Unstimulated release of endothelium derived relaxing factor is independent of mitochondrial ATP generation

1987 • 27 citations

Co-Transmission

1982 • 27 citations

Cardiovascular pharmacology

1991 • 27 citations

RENAL VASOCONSTRICTION IS MODULATED BY NITRIC OXIDE

1992 • 24 citations

ELECTRICAL AND MECHANICAL RESPONSES OF THE BOVINE RETRACTOR PENIS TO NERVE STIMULATION AND TO DRUGS

1984 • 21 citations

Modulation of Norepinephrine-Induced Vasoconstriction by Endothelin-1 and Nitric Oxide in Rat Tail Artery

1991 • 21 citations

Nitric oxide mediates non-adrenergic non-cholinergic relaxation in some neuroeffector systems: examples of nitrergic transmission

1990 • 20 citations

NO: possible role in TTX-sensitive field-stimulated relaxations of the rat oesophageal tunica muscularis mucosae?

1990 • 20 citations

The effects of L‐arginine and N^G‐monomethyl L‐arginine on the inhibitory neurotransmission of the human corpus cavernosum penis

1990 • 20 citations

THE ACTION OF TETRAETHYL‐AMMONIUM CHLORIDE ON THE RESPONSE OF THE RAT ANOCOCCYGEUS MUSCLE TO MOTOR AND INHIBITORY NERVE STIMULATION AND TO SOME DRUGS

1976 • 19 citations

Prejunctional alpha adrenoceptor and angiotensin receptor function in isolated human, monkey and dog arteries.

1988 • 18 citations

The effect of hypoxia on neuroeffector transmission in the bovine retractor penis and rat anococcygeus muscles

1985 • 17 citations

Nonadrenergic noncholinergic mechanisms in the ileocolonic junction.

1990 • 17 citations

THE EFFECT OF ETHANOL ON INHIBITORY AND MOTOR RESPONSES IN THE RAT AND RABBIT ANOCOCCYGEUS AND THE BOVINE RETRACTOR PENIS MUSCLES

1982 • 17 citations

Action of atrial natriuretic peptide (ANP) on dog cerebral arteries: evidence that neurogenic relaxation is not mediated by release of ANP

1989 • 16 citations

Suppression by NG-Monomethyl-l-Arginine of Cerebroarterial Responses to Nonadrenergic, Noncholinergic Vasodilator Nerve Stimulation

1991 • 15 citations

Suppression by NG-Monomethyl-L-Arginine of Cerebroarterial Responses to Nonadrenergic, Noncholinergic Vasodilator Nerve Stimulation

1991 • 14 citations

Nitric oxide: Mediator of nonadrenergic noncholinergic hyperpolarization of opossum esophageal circular smooth muscle

1991 • 10 citations

Nitric Oxide Release in Response to Stimulation of Nonadrenergic, Noncholinergic Nerves

1991 • 9 citations

Nitric Oxide Release in Response to Stimulation of Nonadrenergic, Noncholinergic Nerves

1991 • 7 citations

Influence of NG-nitro-L-arginine methyl ester on vagally-induced gastric relaxation in the rat.

1991 • 5 citations

FUTURE DIRECTIONS IN CARDIOVASCULAR RESEARCH

1991 • 3 citations

FAILURE OF THE NITROUS OXIDE TISSUE EQUILIBRATION METHOD FOR THE DETERMINATION OF BRAIN AND MYOCARDIAL BLOOD FLOW UNDER CONTROLLED CONDITIONS

1992 • 2 citations

N-nitro-arginine inhibits nitric oxide biosynthesis and causes hypertension in rats

1990 • 2 citations