The role of nitric oxide in nociception

Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of a chronic constriction injury, transection, and strychnine

1990 • 356 citations

Molecular biology of nitric oxide synthases.

1998 • 326 citations

Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat

1992 • 298 citations

Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts

1996 • 285 citations

GABA decreases in the spinal cord dorsal horn after peripheral neurectomy

1993 • 262 citations

Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat

1999 • 191 citations

Nitric Oxide Synthases: Gene Structure and Regulation

1995 • 189 citations

Glyceryl Trinitrate Induces Attacks of Migraine Without Aura in Sufferers of Migraine with Aura

1999 • 184 citations

Effect of inhibition of nitric oxide synthase on chronic tension-type headache: a randomised crossover trial

1999 • 177 citations

Reorganization of the spinal dorsal horn in models of chronic pain: correlation with behaviour

1997 • 160 citations

Regulation of Expression of the Sensory Neuron-Specific Sodium Channel SNS in Inflammatory and Neuropathic Pain

1997 • 157 citations

Nitric oxide synthase and GABA colocalize in lamina II of rat spinal cord

1992 • 149 citations

Cyclic GMP pathway is critical for inducing long–term sensitization of nociceptive sensory neurons

1999 • 138 citations

Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain

1999 • 136 citations

Local nitric oxide synthase activity in a model of neuropathic pain

1998 • 102 citations

The role of systemic, spinal and supraspinal l-arginine–nitric oxide–cGMP pathway in thermal hyperalgesia caused by intrathecal injection of glutamate in mice.

1999 • 99 citations

Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan‐induced thermal hyperalgesia

1999 • 97 citations

Nitric Oxide Mediates the Central Sensitization of Primate Spinothalamic Tract Neurons

1999 • 96 citations

Nitric oxide mediates behavioral signs of neuropathic pain in an experimental rat model

1998 • 91 citations

Neuropathic pain in rats is associated with altered nitric oxide synthase activity in neural tissue

1996 • 90 citations

A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS

1999 • 90 citations

Neuronal Nitric Oxide Synthase mRNA Upregulation in Rat Sensory Neurons after Spinal Nerve Ligation: Lack of a Role in Allodynia Development

1999 • 89 citations

Activation of Spinal N-methyl-D-aspartate Receptors Stimulates a Nitric Oxide/Cyclic Guanosine 3′,5′-monophosphate/Glutamate Release Cascade in Nociceptive Signaling

1999 • 88 citations

Endogenous nitric oxide is required for tonic cholinergic inhibition of spinal mechanical transmission

1993 • 87 citations

Involvement of excitatory amino acid receptors and nitric oxide in the rostral ventromedial medulla in modulating secondary hyperalgesia produced by mustard oil

1999 • 81 citations

Possible involvement of nitric oxide in NMDA-induced glutamate release in the rat striatum: an in vivo microdialysis study

1997 • 74 citations

Platelet Nitric Oxide Metabolites in Migraine

1999 • 73 citations

Involvement of Glutamate Receptors in Strychnine- and Bicuculline-induced Allodynia in Conscious Mice

1996 • 58 citations

Rapid development of nitric oxide-induced hyperalgesia depends on an alternate to the cGMP-mediated pathway in the rat neuropathic pain model

1998 • 56 citations

Transdermal Nitroglycerine Enhances Spinal Sufentanil Postoperative Analgesia following Orthopedic Surgery

1999 • 55 citations

Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons

1990 • 55 citations

Lack of Correlation between the Reduction of Sevoflurane MAC and the Cerebellar Cyclic GMP Concentrations in Mice Treated with 7-Nitroindazole

1998 • 52 citations

The controversy about spinal neuronal nitric oxide synthase: under which conditions is it up- or downregulated?

1999 • 52 citations

Role of Nitric Oxide in the Development of Thermal Hyperesthesia Induced by Sciatic Nerve Constriction Injury in the Rat

1995 • 49 citations

The role of nitric oxide and prostaglandin signaling pathways in spinal nociceptive processing in chronic inflammation

2000 • 48 citations

Localization of NADPHd-exhibiting neurons in the spinal cord of the rabbit

1999 • 47 citations

Nitric Oxide–Mediated Spinal Disinhibition Contributes to the Sensitization of Primate Spinothalamic Tract Neurons

1999 • 46 citations

Association between arthroscopic diagnosis of temporomandibular joint osteoarthritis and synovial fluid nitric oxide levels

1999 • 43 citations

NOS Inhibitor Antagonism of PGE₂-Induced Mechanical Sensitization of Cutaneous C-Fiber Nociceptors in the Rat

1999 • 39 citations

Nitric oxide synthase and glutamate receptor immunoreactivity in the rat spinal trigeminal neurons expressing Fos protein after formalin injection

2000 • 38 citations

Gamma subunit dependent modulation by nitric oxide (NO) in recombinant GABAA receptor

1998 • 36 citations

Inhibition of inducible nitric oxide synthase in persistent pain

1999 • 35 citations

Inhibition of Primate Spinothalamic Tract Neurons by Spinal Glycine and GABA Is Modulated by Guanosine 3′,5′-Cyclic Monophosphate

1999 • 26 citations

Cerebrospinal fluid nitric oxide metabolites in painful diseases

1999 • 24 citations

Antinociceptive properties and nitric oxide synthase inhibitory action of new ruthenium complexes

1999 • 20 citations

Expression of NADPH-diaphorase and colocalization with Fos in the brain neurons of the rat following visceral noxious stimulation

1999 • 11 citations

Intrathecal Oxotremorine Affects Formalin-Induced Behavior and Spinal Nitric Oxide Synthase Immunoreactivity in Rats

1999 • 7 citations

Protein kinase and phosphatase modulation of quail brain GABAA and non-NMDA receptors co-expressed in Xenopus oocytes

2000 • 4 citations

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