Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1990 • 1,102 citations

Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin

1987 • 857 citations

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1983 • 680 citations

Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia

1989 • 600 citations

Acute Effects of Typical and Atypical Antipsychotic Drugs on the Release of Dopamine from Prefrontal Cortex, Nucleus Accumbens, and Striatum of the Rat: An In Vivo Microdialysis Study

1990 • 407 citations

Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum

1978 • 401 citations

An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates

1988 • 349 citations

Excitatory amino acid projections to the nucleus accumbens septi in the rat: A retrograde transport study utilizingd[3H]aspartate and [3H]GABA

1987 • 339 citations

Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.

1986 • 309 citations

Ionic Composition of Microdialysis Perfusing Solution Alters the Pharmacological Responsiveness and Basal Outflow of Striatal Dopamine

1989 • 281 citations

Release-regulating D-2 dopamine receptors are located on striatal glutamatergic nerve terminals.

1988 • 229 citations

Dopaminergic Modulation of Glutamate Release in Striatum as Measured by Microdialysis

1992 • 225 citations

Differential regional development of tolerance to increase in dopamine turnover upon repeated neuroleptic administration

1977 • 212 citations

Positive and Negative Schizophrenic Symptoms and the Role of Dopamine

1980 • 206 citations

Dopamine receptors: Pharmacological and anatomical evidences indicate that two distinct dopamine receptor populations are present in rat striatum

1978 • 203 citations

Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens

1991 • 201 citations

Activation of dopamine receptors inhibits calcium-dependent glutamate release from cotico-striatal terminals in vitro

1980 • 189 citations

Modulation of striatal [3H]-glutamic acid release by dopaminergic drugs

1980 • 169 citations

The effect of intraventricular administration of the 5-HT3 receptor agonist 2-methylserotonin on the release of dopamine in the nucleus accumbens: an in vivo chronocoulometric study

1990 • 160 citations

Evidence of glutamatergic deficiency in schizophrenia

1991 • 154 citations

Mesocortical dopamine neurons: rapid transmitter turnover compared to other brain catecholamine systems.

1981 • 131 citations

On the mechanism of neuroleptic induced increase in striatal dopamine release: Brain dialysis provides direct evidence for mediation by autoreceptors localized on nerve terminals

1989 • 125 citations

Regional, reversible ultrastructural changes in rat brain with chronic neuroleptic treatment

1989 • 118 citations

Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats

1993 • 118 citations

Distinct actions of endogenous excitatory amino acids on the outflow of dopamine in the nucleus accumbens.

1993 • 110 citations

A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis

1990 • 103 citations

Chronic treatment with classical and atypical antipsychotic drugs differentially decreases dopamine release in striatum and nucleus accumbens in vivo

1987 • 99 citations

Serotonin-glutamate interaction in rat cerebellum: involvement of 5-HT1 and 5-HT2 receptors

1988 • 77 citations

An Animal Model for Coexisting Tardive Dyskinesia and Tardive Parkinsonism

1993 • 75 citations

Haloperidol given chronically decreases basal dopamine in the prefrontal cortex more than the striatum or nucleus accumbens as simultaneously measured by microdialysis

1989 • 74 citations

Deficient NMDA-mediated glutamate release from synaptosomes of schizophrenics

1991 • 71 citations

Kainic acid lesions of striatum and decortication reduce specific [3H]sulpiride binding in rats, so D-2 receptors exist post-synaptically on corticostriate afferents and striatal neurons

1981 • 69 citations

Differential effects of repeated treatment with haloperidol and clozapine on dopamine release and metabolism in the striatum and the nucleus accumbens.

1991 • 69 citations

Chronic haloperidol decreases dopamine release in striatum and nucleus accumbens in vivo: Depolarization block as a possible mechanism of action

1987 • 66 citations

Effect of haloperidol and clozapine on the density of “perforated” synapses in caudate, nucleus accumbens, and medial prefrontal cortex

1992 • 63 citations

Aspartate-releasing nerve terminals in rat striatum possess D-2 dopamine receptors mediating inhibition of release.

1989 • 59 citations

The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis

1990 • 59 citations

Depolarization inactivation of dopamine neurons: Terminal release characteristics

1993 • 58 citations

Selective inhibition of mesolimbic dopamine release following chronic administration of clozapine: involvement of α1-noradrenergic receptors demonstrated by in vivo voltammetry

1988 • 55 citations

Selective cortical infarction reduces [³H]sulpiride binding in rat caudate‐putamen: Autoradiographic evidence for presynaptic D2 receptors on corticostriate terminals

1988 • 51 citations

Alterations in Extracellular and Tissue Levels of Biogenic Amines in Rat Brain Induced by the Serotonin₂ Receptor Antagonist, Ritanserin

1992 • 51 citations

Chronic treatment with clozapine selectively decreases basal dopamine release in nucleus accumbens but not in caudate-putamen as measured by in vivo brain microdialysis: Further evidence for depolarization block

1991 • 49 citations

Inhibitory effects of dopamine on high affinity glutamate uptake from rat striatum

1982 • 48 citations

Striatal dopamine metabolism increases during long-term haloperidol administration in rats but shows tolerance in response to acute challenge with raclopride

1991 • 45 citations

In vivo release of endogenous glutamate and aspartate in the rat striatum during stimulation of the cortex

1990 • 36 citations

The contrasting effects of neuroleptics on transmitter release from the nucleus accumbens and corpus striatum

1982 • 36 citations

The effect of chronic atypical antipsychotic drugs and haloperidol on amphetamine-induced dopamine release in vivo

1992 • 35 citations

Subcortical excitatory amino acid levels after acute and subchronic administration of typical and atypical neuroleptics

1993 • 35 citations

Effect of chronic haloperidol treatment on stimulated synaptic overflow of dopamine in the rat striatum.

1992 • 32 citations

Effects of the 5-HT2 receptor antagonist, ritanserin, on biogenic amines in the rat nucleus accumbens

1991 • 31 citations

Apomorphine does not reverse reduced basal dopamine release in rat striatum and nucleus accumbens after chronic haloperidol treatment

1990 • 29 citations

Cerebral Glutamate, Neuroleptic Drugs and Schizophrenia: Increase of Cerebrospinal Fluid Glutamate Levels and Decrease of Striate Body Glutamate Levels following Sulpiride Treatment in Rats

1983 • 25 citations

Effects of acute and chronic systemic administration of some typical antipsychotic drugs on turnover of dopamine and potassium ion-induced release of dopamine in the striatum of the rat in vivo

1991 • 24 citations

Regional differences in chronic neuroleptic effects on extracellular dopamine activity

1992 • 24 citations

Effects of acute and chronic clozapine on dopaminergic function in medial prefrontal cortex of awake, freely moving rats

1992 • 23 citations

A rapid and simple HPLC microassay for biogenic amines in discrete brain regions

1988 • 22 citations

Coadministration of haloperidol and SCH-23390 prevents the increase in "perforated" synapses due to either drug alone.

1992 • 17 citations

Supersensitivity of presynaptic receptors involved in the dopaminergic control of striatal high affinity glutamate uptake after 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons

1988 • 14 citations

The effect of chronic clozapine on basal dopamine release and apomorphine-induced DA release in the striatum and nucleus accumbens as measured by in vivo brain microdialysis

1992 • 11 citations

Alterations in dopamine release from striatal slices of rats after chronic treatment with haloperidol

1991 • 9 citations

The effects of clozapine on dopamine, 5-HT, and glutamate release in the rat medial prefrontal cortex

1991 • 8 citations

Decrease in the evoked release of endogenous dopamine and dihydroxyphenyiacetic acid from rat striatal slices after withdrawal from repeated haloperidol

1990 • 5 citations