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Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex

1985 • 1,984 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Intrinsic firing patterns of diverse neocortical neurons

1990 • 1,447 citations

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

1991 • 1,157 citations

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1990 • 1,102 citations

Voltage-clamp analysis of muscarinic excitation in hippocampal neurons

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The Cortex of the Rat

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Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

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1987 • 554 citations

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1988 • 554 citations

Voltage clamp analysis of cholinergic action in the hippocampus

1987 • 509 citations

Specific in vitro and in vivo binding of 3H-raclopride a potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain

1985 • 503 citations

Dopamine receptor sequences. Therapeutic levels of neuroleptics occupy D2 receptors, clozapine occupies D4.

1992 • 445 citations

Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics

1996 • 440 citations

Ketamine activates psychosis and alters limbic blood flow in schizophrenia

1995 • 438 citations

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1993 • 401 citations

Frontal Cortical and Left Temporal Glutamatergic Dysfunction in Schizophrenia

1989 • 392 citations

Physiological and morphological identification of somatostatin- or vasoactive intestinal polypeptide-containing cells among GABAergic cell subtypes in rat frontal cortex

1996 • 379 citations

Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.

1996 • 342 citations

D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients

1995 • 341 citations

The NMDA-receptor antagonist CPP abolishes neurogenic ‘wind-up pain’ after intrathecal administration in humans

1992 • 302 citations

A “Glutamatergic Hypothesis” of Schizophrenia

1989 • 270 citations

Electrophysiological and morphological properties of layers V-VI principal pyramidal cells in rat prefrontal cortex in vitro

1996 • 260 citations

The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1

1993 • 254 citations

(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

1989 • 250 citations

Antipsychotic agents antagonize non-competitiveN-methyl-d-aspartate antagonist-induced behaviors

1995 • 248 citations

Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem

1990 • 246 citations

Decreased hippocampal expression of a glutamate receptor gene in schizophrenia

1991 • 241 citations

Release-regulating D-2 dopamine receptors are located on striatal glutamatergic nerve terminals.

1988 • 229 citations

Regulation of N‐methyl‐D‐aspartate receptors revealed by intracellular dialysis of murine neurones in culture.

1989 • 225 citations

Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice

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Increased [3H]kainic acid binding in the prefrontal cortex in schizophrenia

1983 • 201 citations

Developmental changes in NMDA and non-NMDA receptor-mediated synaptic potentials in rat neocortex

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Presynaptic dopaminergic modulation of cortical input to the striatum

1986 • 184 citations

Actions of 5-hydroxytryptamine on neurons of the rat cingulate cortex

1993 • 183 citations

Pharmacological actions of the atypical antipsychotic drug clozapine: A review

1996 • 181 citations

Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs

1995 • 171 citations

Positron Emission Tomography Studies on D2 and 5-HT2 Receptor Binding in Risperidone-Treated Schizophrenic Patients

1995 • 156 citations

Clozapine and seizures

1990 • 132 citations

Somatostatin inhibition of hippocampal CA1 pyramidal neurons: mediation by arachidonic acid and its metabolites

1993 • 122 citations

Blockade of phencyclidine-induced hyperlocomotion by clozapine and MDL 100,907 in rats reflects antagonism of 5-HT2A receptors

1995 • 121 citations

Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats

1993 • 118 citations

Increases in strychnine-insensiive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis

1994 • 114 citations

GABAB receptor antagonists: from synthesis to therapeutic applications

1993 • 107 citations

Autoreceptor Regulation of Glutamate and Aspartate Release from Slices of the Hippocampal CA1 Area

1991 • 104 citations

Olanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxicity

1996 • 100 citations

Glutamate: a new target in schizophrenia?

1990 • 98 citations

Excitatory Amino Acid Receptors in Schizophrenia

1993 • 90 citations

Alterations in phencyclidine and sigma binding sites in schizophrenic brains

1991 • 90 citations

Chapter 26 The prefrontal cortex in schizophrenia and other neuropsychiatric diseases: in vivo physiological correlates of cognitive deficits

1991 • 88 citations

Regulation of ionotropic glutamate receptors following subchronic and chronic treatment with typical and atypical antipsychotics

1996 • 86 citations

Brain region effects of clozapine on amino acid and monoamine transmission.

1994 • 80 citations

Serotonin-glutamate interaction in rat cerebellum: involvement of 5-HT1 and 5-HT2 receptors

1988 • 77 citations

Glutamate agonist activity

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Single-electrode voltage-clamp analysis of the N-methyl-D-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy

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Optimal Voltage Clamping With Single Microelectrode

1985 • 61 citations

Aspartate-releasing nerve terminals in rat striatum possess D-2 dopamine receptors mediating inhibition of release.

1989 • 59 citations

Chronic haloperidol treatment enhances binding to NMDA receptors in rat cortex

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Anti-glutamatergic effects of clozapine

1993 • 54 citations

Recent basic findings in support of excitatory amino acid hypotheses of schizophrenia

1994 • 50 citations

Inhibition of N-methyl-D-aspartate receptors by haloperidol: developmental and pharmacological characterization in native and recombinant receptors.

1996 • 50 citations

Metabotropic glutamate receptor agonist-induced hyperpolarizations in rat basolateral amygdala neurons: receptor characterization and ion channels

1996 • 47 citations

NMDA-induced response in pyramidal neurons of the rat medial prefrontal cortex slices consists of NMDA and non-NMDA components

1997 • 32 citations

Biphasic modulation of evoked [³H]D‐aspartate release by D‐2 dopamine receptors in rat striatal slices

1988 • 24 citations

Pharmacokinetics of neuroleptics.

1991 • 21 citations

The effect of haloperidol on the ionic currents in the voltage-clamped node of Ranvier.

1978 • 17 citations

High concentrations of the neuroleptic remoxipride block voltage-activated Na+ channels in central and peripheral nerve membranes

1992 • 15 citations

The effects of cAMP, Ca2+, and phorbol esters on ouabain-induced depression of acetylcholine responses inHelix neurons

1992 • 15 citations

Clozapine-induced potentiation of synaptic responses in the perforant path-dentate gyrus pathway in chronically prepared rabbits

1996 • 15 citations

Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial

1995 • 14 citations

Concentration jump studies of intracellularly dialysed Xenopus oocytes show desensitization of kainate receptors

1991 • 11 citations

Antipsychotic drugs interact with 5-HT2A receptors to potentiate NMDA response in pyramidal cellsof the medial prefrontal cortex

1997 • 1 citations