Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rats

The functional anatomy of basal ganglia disorders

1989 • 5,166 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Mitochondrial Diseases in Man and Mouse

1999 • 3,008 citations

Neuropathological Classification of Huntingtonʼs Disease

1985 • 2,517 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

Positron Emission Tomographic Analysis of Central D1 and D2 Dopamine Receptor Occupancy in Patients Treated With Classical Neuroleptics and Clozapine

1992 • 1,420 citations

The Basal Ganglia and Adaptive Motor Control

1994 • 1,295 citations

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1993 • 1,017 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Dopamine receptor pharmacology

1994 • 959 citations

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1976 • 832 citations

Tardive Dyskinesia

1982 • 660 citations

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

1992 • 626 citations

Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1993 • 583 citations

Increase in caudate nuclei volumes of first-episode schizophrenic patients taking antipsychotic drugs

1994 • 572 citations

Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum

1978 • 401 citations

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.

1988 • 384 citations

Age‐Dependent Vulnerability of the Striatum to the Mitochondrial Toxin 3‐Nitropropionic Acid

1993 • 360 citations

Parkinson's disease and movement disorders

1989 • 353 citations

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

1989 • 347 citations

Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines

1993 • 318 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide

1993 • 261 citations

Identifying Risk Factors for Tardive Dyskinesia Among Long-term Outpatients Maintained With Neuroleptic Medications

1993 • 260 citations

Gender Differences in Tardive Dyskinesia: A Critical Review of the Literature

1992 • 258 citations

Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis

1984 • 252 citations

Markers of Glutamatergic Neurotransmission and Oxidative Stress Associated With Tardive Dyskinesia

1998 • 247 citations

Dopamine D3-receptor gene variant and susceptibility to tardive dyskinesia in schizophrenic patients

1997 • 242 citations

Randomised double-blind comparison of the incidence of tardive dyskinesia in patients with schizophrenia during long-term treatment with olanzapine or haloperidol

1999 • 242 citations

Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, pathophysiology and putative relationship to tardive dyskinesia

1990 • 242 citations

Tardive Dyskinesia: A Task Force Report of the American Psychiatric Association

1993 • 232 citations

Lower Incidence of Tardive Dyskinesia with Risperidone Compared with Haloperidol in Older Patients

1999 • 231 citations

Oxygen Radicals and Neuropsychiatric Illness

1991 • 230 citations

Prospective Study of Tardive Dyskinesia in the Elderly: Rates and Risk Factors

1998 • 227 citations

Dopaminergic Modulation of Glutamate Release in Striatum as Measured by Microdialysis

1992 • 225 citations

Persistent Dyskinesia

1973 • 222 citations

Acute dystonia induced by neuroleptic drugs

1986 • 220 citations

Neuroleptic medications inhibit complex I of the electron transport chain

1993 • 213 citations

Neurobiological substrates of tardive dyskinesia: the GABA hypothesis

1984 • 209 citations

Anterior striatal projections to the globus pallidus, entopeduncular nucleus and substantia nigra in the rat: The GABA connection

1978 • 206 citations

Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations

1994 • 203 citations

Induction of Reactive Oxygen Species in Neurons by Haloperidol

1998 • 195 citations

Tardive Dyskinesia—Reversible and Persistent

1979 • 195 citations

Spontaneous Orofacial Dyskinesia and Dopaminergic Function in Rats After 6 Months of Neuroleptic Treatment

1983 • 193 citations

Increased indices of free radical activity in the cerebrospinal fluid of patients with tardive dyskinesia

1990 • 177 citations

Modulation of striatal [3H]-glutamic acid release by dopaminergic drugs

1980 • 169 citations

Changes in dopamine-mediated behaviour during one year's neuroleptic administration

1979 • 160 citations

Does dopamine play a role in schizophrenia?

1977 • 160 citations

Induction of NF-κB Activity during Haloperidol-Induced Oxidative Toxicity in Clonal Hippocampal Cells: Suppression of NF-κB and Neuroprotection by Antioxidants

1998 • 153 citations

Abusive stimulation of excitatory amino acid receptors: a strategy to limit neurotoxicity

1990 • 152 citations

The Phenothiazinetranquilizers: Biochemical and Biophysical Actions

1964 • 152 citations

Free radicals and tardive dyskinesia

1986 • 151 citations

The basal ganglia.

1995 • 150 citations

The Prevalence of Tardive Dyskinesia

1991 • 149 citations

Treatment of tardive dyskinesia with vitamin E

1992 • 148 citations

Effect of fluoxetine on the electrocardiogram.

1985 • 142 citations

Reduction of nigral glutamic acid decarboxylase in rats with neuroleptic-induced oral dyskinesia

1983 • 140 citations

Haloperidol-induced morphological changes in striatum are associated with glutamate synapses

1994 • 135 citations

Loss of striatal cholinergic neurons as a basis for tardive and L-dopa-induced dyskinesias, neuroleptic-induced supersensitivity psychosis and refractory schizophrenia

1993 • 134 citations

Treatment of schizophrenia: A clinical and preclinical evaluation of neuroleptic drugs

1993 • 132 citations

Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids.

1990 • 132 citations

IMPAIRMENT OF PHAGOCYTOSIS BY GRANULOCYTES IN BRAIN-DAMAGED PATIENTS

1973 • 127 citations

Tardive dyskinesia and atypical antipsychotic drugs

1999 • 124 citations

Improvement in Tardive Dyskinesia After Muscimol Therapy

1979 • 123 citations

MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies.

1994 • 121 citations

Oral dyskinesia in rats following brain lesions and neuroleptic drug administration

1982 • 118 citations

Remodeling of synaptic architecture during hippocampal "kindling".

1988 • 118 citations

Oral stereotypy induced by amphetamine microinjection into striatum: An anatomical mapping study

1994 • 116 citations

Cholinergic stimulation of the ventrolateral striatum elicits mouth movements in rats: pharmacological and regional specificity

1989 • 116 citations

Pharmacological characterisation of spontaneous or drug-associated purposeless chewing movements in rats

1985 • 113 citations

Cholinergic manipulation of perioral behaviour induced by chronic neuroleptic administration to rats

1983 • 111 citations

Excitotoxins, Aging, and Environmental Neurotoxins: Implications for Understanding Human Neurodegenerative Diseases

1995 • 109 citations

Characterization of the potential antioxidant and pro-oxidant actions of some neuroleptic drugs

1995 • 109 citations

Inhibition of complex I by neuroleptics in normal human brain cortex parallels the extrapyramidal toxicity of neuroleptics

1997 • 108 citations

EVIDENCE OF ENHANCED LIPID PEROXIDATION IN THE CEREBROSPINAL FLUID OF PATIENTS TAKING PHENOTHIAZINES

1987 • 105 citations

Neuroleptic-induced vacuous chewing movements as an animal model of tardive dyskinesia: a study in three rat strains

1990 • 105 citations

Effect of aging on concentrations of D2-receptor-containing neurons in the rat striatum

1989 • 103 citations

Predictors of Improvement in Tardive Dyskinesia Following Discontinuation of Neuroleptic Medication

1990 • 101 citations

Schizophrenia, Affective Psychoses, and Other Disorders Treated with Neuroleptic Drugs: The Enigma of Tardive Dyskinesia, Its Neurobiological Determinants, and the Conflict of Paradigms

1989 • 99 citations

Spontaneous chewing movements in rats during acute and chronic antipsychotic drug administration

1986 • 98 citations

Non-functional CYP2D6 alleles and risk for neuroleptic-induced movement disorders in schizophrenic patients

1997 • 97 citations

Movement disorders in neurology and neuropsychiatry

1993 • 97 citations

Free radical mechanisms in schizophrenia and tardive dyskinesia

1994 • 96 citations

Evidence for cell loss in corpus striatum after long-term treatment with a neuroleptic drug (flupenthixol) in rats

1978 • 96 citations

Untitled

1997 • 95 citations

Haloperidol-induced cell death—mechanism and protection with vitamin E in vitro

1995 • 87 citations

Ultrastructural correlates of haloperidol‐induced oral dyskinesias in rat striatum

1995 • 86 citations

Alterations in mRNA levels of D2 receptors and neuropeptides in striatonigral and striatopallidal neurons of rats with neuroleptic‐induced dyskinesias

1994 • 85 citations

Neuroleptic-induced oral dyskinesias: effects of progabide and lack of correlation with regional changes in glutamic acid decarboxylase and choline acetyltransferase activities

1987 • 84 citations

MRI abnormalities in tardive dyskinesia

1991 • 82 citations

Familial tardive dyskinesia

1981 • 81 citations

Pharmacological and neurochemical differences between acute and tardive vacuous chewing movements induced by haloperidol

1996 • 81 citations

Novel antipsychotics, extrapyramidal side effects and tardive dyskinesia

1998 • 80 citations

Neuroleptic-induced mitochondrial enzyme alterations in the rat brain.

1997 • 80 citations

Basal Ganglia GABAA and Dopamine D1 Binding Site Correlates of Haloperidol-Induced Oral Dyskinesias in Rat

1994 • 77 citations

Chronic haloperidol, but not clozapine, produces altered oral movements and increased extracellular glutamate in rats

1994 • 75 citations

An Animal Model for Coexisting Tardive Dyskinesia and Tardive Parkinsonism

1993 • 75 citations

The long-term effect of perphenazine enanthate on the rat brain. Some metabolic and anatomical observations

1973 • 73 citations

An unusual cluster of tardive dyskinesia in schizophrenia: association with cognitive dysfunction and negative symptoms

1986 • 73 citations

Effectiveness of vitamin E for treatment of long-term tardive dyskinesia

1994 • 69 citations

Prevalence of abnormal involuntary movements (?spontaneous dyskinesias?) in the normal elderly

1982 • 66 citations

1-Methyl-4-phenylpyridinium-like neurotoxicity of a pyridinium metabolite derived from haloperidol: cell culture and neurotransmitter uptake studies.

1994 • 66 citations

The Effect of Chronic Haloperidol Treatment on Dendritic Spines in the Rat Striatum

1997 • 64 citations

Effect of haloperidol and clozapine on the density of “perforated” synapses in caudate, nucleus accumbens, and medial prefrontal cortex

1992 • 63 citations

Study of neuropathologic changes in the striatum following 4, 8 and 12 months of treatment with fluphenazine in rats

1992 • 60 citations

Aspartate-releasing nerve terminals in rat striatum possess D-2 dopamine receptors mediating inhibition of release.

1989 • 59 citations

Depolarization inactivation of dopamine neurons: Terminal release characteristics

1993 • 58 citations

Neuroleptic-induced oral movements in rats: Methodological issues

1987 • 57 citations

Behavioral consequences of long-term treatment with neuroleptic drugs.

1980 • 57 citations

Vitamin E, lipids, and lipid peroxidation products in tardive dyskinesia

1998 • 57 citations

Biphasic nature of the binding of cationic amphipaths with artificial and biological membranes

1988 • 52 citations

MRI in tardive dyskinesia: Shortened left caudate T2

1990 • 52 citations

Intermittent and continuous haloperidol regimens produce different types of oral dyskinesias in rats

1990 • 51 citations

Selective cortical infarction reduces [³H]sulpiride binding in rat caudate‐putamen: Autoradiographic evidence for presynaptic D2 receptors on corticostriate terminals

1988 • 51 citations

Tardive Dyskinesia: Reversible and Irreversible

1985 • 51 citations

Age-related changes in glutamate concentration and synaptosomal glutamate uptake in adult rat striatum

1981 • 50 citations

Tardive dyskinesia and substrates of energy metabolism in CSF

1995 • 50 citations

Familial occurrence of tardive dyskinesia.

1981 • 49 citations

Excitotoxic Mechanisms May Be Involved in the Pathophysiology of Tardive Dyskinesia

1991 • 49 citations

The basal ganglia

1995 • 47 citations

In Vivo Analysis of Hydrogen Peroxide and Lipid Radicals in the Striatum of Rats Under Long-Term Administration of a Neuroleptic

1998 • 46 citations

Dyskinesias Evoked in Monkeys by Weekly Administration of Haloperidol

1978 • 46 citations

Striatal dopamine metabolism increases during long-term haloperidol administration in rats but shows tolerance in response to acute challenge with raclopride

1991 • 45 citations

Extracellular glutamate levels increase with age in the lateral striatum: Potential involvement of presynaptic D‐2 receptors

1993 • 44 citations

Oxidative stress-resistant cells are protected against haloperidol toxicity

1996 • 44 citations

Can the supersensitivity of rodents to dopamine be regarded as a model of tardive dyskinesia?

1989 • 44 citations

Vitamin E (α-Tocopherol) in the Treatment of Tardive Dyskinesia: A Statistical Meta-Analysis

1998 • 42 citations

Inhibition by memantine of the development of persistent oral dyskinesias induced by long‐term haloperidol treatment of rats

1996 • 42 citations

Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxinN-methyl-4-phenylpyridinium (MMP+) towards cultured dopaminergic neuroblastoma cells

1995 • 42 citations

Vitamin E (alpha-tocopherol) in the treatment of tardive dyskinesia: a statistical meta-analysis.

1998 • 42 citations

Co-administration of progabide inhibits haloperidol-induced oral dyskinesias in rats

1992 • 41 citations

Correlation of vacuous chewing movements with morphological changes in rats following 1-year treatment with haloperidol

1996 • 41 citations

Semisynthetic sphingolipids prevent protein kinase C translocation and neuronal damage in the perifocal area following a photochemically induced thrombotic brain cortical lesion.

1993 • 41 citations

Semisynthetic sphingolipids prevent protein kinase C translocation and neuronal damage in the perifocal area following a photochemically induced thrombotic brain cortical lesion

1993 • 38 citations

Dose-dependent increases in rat spontaneous chewing rates during long-term administration of haloperidol but not clozapine

1986 • 37 citations

Risperidone

1997 • 36 citations

Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements

1994 • 36 citations

Chronic haloperidol potentiates stimulated glutamate release in caudate putamen, but not prefrontal cortex

1995 • 35 citations

Intermittent versus continuous neuroleptic treatment in a rat model

1990 • 35 citations

GM1 ganglioside attenuates the development of vacuous chewing movements induced by long-term haloperidol treatment of rats

1994 • 35 citations

Possible genetic factors underlying the pathophysiology of tardive dyskinesia

1994 • 33 citations

Oral dyskinesias and striatal lesions in rats after long-term co-treatment with haloperidol and 3-nitropropionic acid

1998 • 32 citations

Gangliosides

1994 • 31 citations

Haloperidol induces persistent down-regulation of tyrosine hydroxylase immunoreactivity in substantia nigra but not ventral tegmental area in the rat

1998 • 31 citations

Mixture in the distribution of haloperidol-induced oral dyskinesias in the rat supports an animal model of tardive dyskinesia

1998 • 31 citations

The dose-response characteristics of rat oral dyskinesias with chronic haloperidol or clozapine administration

1997 • 30 citations

Chronic Olanzapine or Sertindole Treatment Results in Reduced Oral Chewing Movements in Rats Compared to Haloperidol

1998 • 30 citations

Intermittent neuroleptic treatment induces long-lasting abnormal mouthing in the rat

1989 • 30 citations

Neuroleptic-induced vacuous chewing movements in rodents: incidence and effects of long-term increases in haloperidol dose

1995 • 30 citations

The action of chlorpromazine and imipramine on rat brain mitochondria

1979 • 26 citations

Bcl-2 prevents hippocampal cell death induced by the neuroleptic drug haloperidol

1996 • 25 citations

The effect of phenothiazine on the metabolism of liver mitochondria

1965 • 22 citations

The relationship between oral dyskinesias produced by long-term haloperidol treatment, the density of striatal preproenkephalin messenger RNA and enkephalin peptide, and the number of striatal neurons expressing preproenkephalin messenger RNA in rats

1999 • 22 citations

Drug-induced oral dyskinesias in rats after traditional and new neuroleptics

1995 • 21 citations

Persistent vacuous chewing in rats following neuroleptic treatment: relationship to dopaminergic and cholinergic function

1993 • 20 citations

Tiagabine inhibits haloperidol-induced oral dyskinesias in rats

1994 • 19 citations

Effects of rating parameters on assessment of neuroleptic-induced vacuous chewing movements

1996 • 18 citations

Clinical Activity of GABA Agonists in Neuroleptic- and L-Dopa-Induced Dyskinesia

1985 • 18 citations

The relationship between motor effects in rats following acute and chronic haloperidol treatment

1994 • 17 citations

The rat model of tardive dyskinesia: Relationship between vacuous chewing movements and gross motor activity during acute and long-term haloperidol treatment

1995 • 17 citations

Persistent catalepsy associated with severe dyskinesias in rats treated with chronic injections of haloperidol decanoate

1995 • 16 citations

Antipsychotic-Induced Tardive Dyskinesia

1995 • 16 citations

The mitochondrial toxin 3-nitropropionic acid induces vacuous chewing movements in rats. Implications for tardive dyskinesia?

1995 • 15 citations

Chapter 25 CNS Pharmacology of gangliosides

1994 • 15 citations

Development of vacuous chewing movements in rats: Role of housing environment

1991 • 14 citations

Partial attenuation of chronic fluphenazine-induced changes in regional monoamine metabolism by D-α-tocopherol in rat brain

1991 • 14 citations

Reduced number of striatal neurons expressing preprosomatostatin mRNA in rats with oral dyskinesias after long-term haloperidol administration

2000 • 13 citations

Failure to down regulate NMDA receptors in the striatum and nucleus accumbens associated with neuroleptic-induced dyskinesia

1998 • 12 citations

Modulation of NMDA effects on agonist‐stimulated phosphoinositide turnover by memantine in neonatal rat cerebral cortex

1995 • 12 citations

Neuropeptide changes in a primate model (Cebus apella) for tardive dyskinesia

1990 • 11 citations

GABAmimetic treatments for tardive dyskinesia: efficacy and mechanism.

1989 • 11 citations

Intranigral stimulation of oral movements by [Pro9] substance P, a neurokinin-1 receptor agonist, is enhanced in chronically neuroleptic-treated rats

1993 • 10 citations

YM-14673, a thyrotropin-releasing hormone analogue, injected into the nucleus accumbens and the striatum produces repetitive jaw movements in rats

1995 • 7 citations

Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia

1984 • 6 citations

The effect of phenothiazone on the metabolism of liver mitochondria

1965 • 5 citations

Deleted Work

1955 • 0 citations