Comparison of chronic intermittent haloperidol and raclopride effects on striatal dopamine release and synaptic ultrastructure in rats

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

1999 • 3,597 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 2,110 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 1,751 citations

Central D2-Dopamine Receptor Occupancy in Schizophrenic Patients Treated With Antipsychotic Drugs

1988 • 692 citations

Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats

1988 • 516 citations

Specific in vitro and in vivo binding of 3H-raclopride a potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain

1985 • 503 citations

The striatal cholinergic interneuron: Synaptic target of dopaminergic terminals?

1983 • 422 citations

Intermittent versus continuous stimulation: Effect of time interval on the development of sensitization or tolerance

1980 • 384 citations

Subsynaptic Plate Perforations: Changes with Age and Experience in the Rat

1978 • 328 citations

A Study of the Powers of Several Methods of Multiple Comparisons

1975 • 295 citations

Contributions of dendritic spines and perforated synapses to synaptic plasticity

1990 • 289 citations

Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities

1991 • 272 citations

Biphasic effect of D-2 agonist quinpirole on locomotion and movements

1989 • 245 citations

Acute dystonia induced by neuroleptic drugs

1986 • 220 citations

The selective dopamine D2 receptor antagonist raclopride discriminates between dopamine-mediated motor functions

1986 • 215 citations

Presynaptic dopaminergic modulation of cortical input to the striatum

1986 • 184 citations

Ultrastructural morphology of dopaminergic nerve terminals and synapses in the striatum of the rat using tyrosine hydroxylase immunocytochemistry: A topographical study

1984 • 172 citations

Tardive dyskinesia

1988 • 162 citations

Receptor-Binding Profiles of Neuroleptics

1985 • 144 citations

A Study of the Powers of Several Methods of Multiple Comparisons

1975 • 130 citations

The effects of haloperidol on synaptic patterns in the rat striatum

1985 • 127 citations

Regional, reversible ultrastructural changes in rat brain with chronic neuroleptic treatment

1989 • 118 citations

Raclopride, a new selective ligand for the dopamine-D2 receptors

1988 • 114 citations

An open label trial of raclopride in acute schizophrenia. Confirmation of D2-dopamine receptor occupancy by PET

1988 • 112 citations

Tolerance to haloperidol catalepsy

1977 • 106 citations

Sigma binding states in the brain; An emerging concept for multiple sites and their relevance for psychiatric disorders

1990 • 99 citations

Presynaptic regulation of dopaminergic transmission in the striatum

1988 • 81 citations

Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment

1991 • 68 citations

In vivo assessment of release and metabolism of dopamine in the ventrolateral striatum of awake rats following administration of dopamine D1 and D2 receptor agonists and antagonists

1991 • 64 citations

Effect of haloperidol and clozapine on the density of “perforated” synapses in caudate, nucleus accumbens, and medial prefrontal cortex

1992 • 63 citations

Effects of Raclopride on Exploratory Locomotor Activity, Treadmill Locomotion, Conditioned Avoidance Behaviour and Catalepsy in Rats: Behavioural Profile Comparisons between Raclopride, Haloperidol and Preclamol

1987 • 61 citations

The effect of systemically applied cholinergic drugs on the striatal release of dopamine and its metabolites, as determined by automated brain dialysis in conscious rats

1988 • 61 citations

Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats

1990 • 60 citations

Interaction of drug effects with testing procedures in the measurement of catalepsy

1976 • 60 citations

Comparison of chronic administration of haloperidol and the atypical neuroleptics, clozapine and raclopride, in an animal model of tardive dyskinesia

1990 • 53 citations

Intermittent and continuous haloperidol regimens produce different types of oral dyskinesias in rats

1990 • 51 citations

Repeated testing of rats markedly enhances the duration of effects induced by haloperidol on treadmill locomotion, catalepsy, and a conditioned avoidance response

1987 • 48 citations

Tolerance to fluphenazine and supersensitivity to apomorphine in central dopaminergic systems after chronic fluphenazine decanoate treatment

1980 • 48 citations

Chronic neuroleptics alter the effects of the D1 agonist SK&F 38393 and the D2 agonist LY171555 on oral movements in rats

1988 • 47 citations

Dyskinesias Evoked in Monkeys by Weekly Administration of Haloperidol

1978 • 46 citations

Effects of intermittent and continuous haloperidol administration on the dopaminergic system in the rat brain

1986 • 46 citations

Striatal dopamine metabolism increases during long-term haloperidol administration in rats but shows tolerance in response to acute challenge with raclopride

1991 • 45 citations

Treatment schedule as a determinant of the development of tolerance to haloperidol

1984 • 44 citations

Tolerance to behavioral effects of haloperidol

1981 • 41 citations

Selective D₁ and D₂ Receptor Manipulation in Cebus Monkeys: Relevance for Dystonia and Dyskinesia in Humans

1987 • 41 citations

Sensitization versus tolerance to the dopamine turnover-elevating effects of haloperidol: the effect of regular/intermittent dosing

1990 • 38 citations

D-1 and D-2 receptor blockade have additive cataleptic effects in mice, but receptor effects may interact in opposite ways

1988 • 32 citations

Effects of D-2 agonists on the release of dopamine: localization of the mechanism of action

1990 • 30 citations

Apomorphine does not reverse reduced basal dopamine release in rat striatum and nucleus accumbens after chronic haloperidol treatment

1990 • 29 citations

Synergy between a selective D1 antagonist and a selective D2 antagonist in the induction of catalepsy

1989 • 29 citations

Persistent increase in striatal dopamine stimulated adenylate cyclase activity persists for more than 6 months but disappears after 1 year following withdrawal from 18 months cis-flupenthixol intake

1983 • 26 citations

Conditional tolerance to haloperidol-induced catalepsy is not caused by striatal dopamine receptor supersensitivity

1986 • 24 citations

Supersensitivity of striatal D2 dopamine receptors mediating inhibition of adenylate cyclase and stimulation of guanosine triphosphatase following chronic administration of haloperidol in mice

1987 • 22 citations

Comparison of the effects of haloperidol, remoxipride and raclopride on ?pre?- and postsynaptic dopamine receptors in the rat brain

1988 • 21 citations

Coadministration of haloperidol and SCH-23390 prevents the increase in "perforated" synapses due to either drug alone.

1992 • 17 citations

Cholinergic modulation of oral activity in drug-naive and chronic haloperidol-treated rats

1991 • 12 citations

Behavioural and Biochemical Effects of Subchronic Treatment with Raclopride in the Rat: Tolerance and Brain Monoamine Receptor Sensitivity

1991 • 10 citations

Inhibition of dopamine synthesis in rat striatal minces: evidence of dopamine autoreceptor supersensitivity to S(+)- but not R(−)-N-n-propylnorapomorphine after pretreatment with fluphenazine

1991 • 7 citations

Increased Duration of Dopamine Receptor Antagonist‐Induced Effects on both Behaviour and Striatal Dopamine Turnover by Repeated Testing in Rats

1988 • 5 citations

Deleted Work

1955 • 0 citations