Lipid peroxidation: its mechanism, measurement, and significance

Free radicals in biology and medicine

1991 • 17,840 citations

[30] Microsomal lipid peroxidation

1978 • 12,818 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Beyond Cholesterol

1989 • 6,533 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

The deoxyribose method: A simple “test-tube” assay for determination of rate constants for reactions of hydroxyl radicals

1987 • 2,350 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

The Chemical Basis of Radiation Biology

1987 • 1,843 citations

Continuous Monitoring ofin VztroOxidation of Human Low Density Lipoprotein

1989 • 1,824 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems

1991 • 1,555 citations

Free-radical mechanisms in tissue injury

1984 • 1,518 citations

The antioxidants of human extracellular fluids

1990 • 1,352 citations

The measurement and mechanism of lipid peroxidation in biological systems

1990 • 1,273 citations

Mechanisms of carbon tetrachloride toxicity

1989 • 1,250 citations

Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

Role of metals in oxygen radical reactions

1985 • 1,149 citations

Superoxide dismutases

1989 • 953 citations

Antioxidant functions of carotenoids

1989 • 916 citations

Metal-catalyzed oxidation of proteins. Physiological consequences

1991 • 877 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY

1984 • 820 citations

Cytotoxicity and genotoxicity of lipid-oxidation products

1993 • 802 citations

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

1990 • 621 citations

Modulation of fibroblast proliferation by oxygen free radicals

1990 • 617 citations

Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide.

1988 • 614 citations

Central nervous system trauma and strokeII. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation

1989 • 580 citations

Review. Recent advances in lipid oxidation

1991 • 538 citations

A study of the reactivity of HO2/O2- with unsaturated fatty acids.

1983 • 519 citations

Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide

1991 • 487 citations

Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid

1991 • 485 citations

Vitamin E as an in Vitro and in Vivo Antioxidant^a

1989 • 447 citations

Assay of metabolic superoxide production in Escherichia coli.

1991 • 405 citations

Initiation of lipid peroxidation in biological systems

1987 • 385 citations

Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling

1990 • 358 citations

Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans

1991 • 323 citations

The balance between copper-zinc superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress

1991 • 302 citations

Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo?

1989 • 301 citations

Thiobarbituric acid‐reactivity following iron‐dependent free‐radical damage to amino acids and carbohydrates

1981 • 284 citations

Will antioxidant nutrients slow aging processes?

1968 • 279 citations

The role of iron in the initiation of lipid peroxidation

1987 • 268 citations

Oxygen Radicals and Tissue Injury

1997 • 257 citations

Copper salt-dependent hydroxyl radical formation

1983 • 242 citations

The mechanism of initiation of lipid peroxidation. Evidence against a requirement for an iron(II)-iron(III) complex

1989 • 212 citations

Perhydroxyl radical (HOO.) initiated lipid peroxidation. The role of fatty acid hydroperoxides

1991 • 209 citations

Determination of malonaldehyde in biological materials by high-pressure liquid chromatography

1983 • 202 citations

Biokinetics of dietaryRRR‐α‐tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not “spare” vitamin Ein vivo

1990 • 197 citations

The Inhibition of Lipid Autoxidation by Human Serum and its Relation to Serum Proteins and α-Tocopherol

1974 • 188 citations

The effect of ionizing radiation on lipid membranes

1991 • 183 citations

Mechanisms of oxidant injury of cells

1991 • 177 citations

Lipid hydroperoxide involvement in copper-dependent and independent oxidation of low density lipoproteins.

1991 • 177 citations

Glutathione depleting agents and lipid peroxidation

1987 • 174 citations

Aspects to Consider When Detecting and Measuring Lipid Peroxidation

1986 • 172 citations

Singlet oxygen production from the reactions of ozone with biological molecules

1991 • 168 citations

Malondialdehyde formation from lipid peroxides in the thiobarbituric acid test: the role of lipid radicals, iron salts, and metal chelators.

1983 • 162 citations

Role of tocopherols in the protection of biological systems against oxidative damage

1991 • 151 citations

Selective microdetermination of lipid hydroperoxides

1985 • 149 citations

The Control of Oxidant Stress at Fertilization

1991 • 149 citations

In vivo externalization of phosphatidylserine and phosphatidylethanolamine in the membrane bilayer and hypercoagulability by the lipid peroxidation of erythrocytes in rats.

1985 • 138 citations

Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane

1991 • 130 citations

Formation of yellow, orange, and red pigments in the reaction of alk-2-enals with 2-thiobarbituric acid

1987 • 128 citations

Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs.

1991 • 120 citations

Rapid headspace gas chromatography of hexanal as a measure of lipid peroxidation in biological samples

1989 • 119 citations

Phospholipid hydroperoxide glutathione peroxidase is the 18-kDa selenoprotein expressed in human tumor cell lines.

1991 • 118 citations

Free malondialdehyde determination in human plasma by high-performance liquid chromatography

1988 • 116 citations

Role of prostaglandin endoperoxides in the serum thiobarbituric acid reaction

1981 • 116 citations

The experimental and clinical pathology of diene conjugation

1987 • 100 citations

Quantification of noncyclooxygenase derived prostanoids as a marker of oxidative stress

1991 • 97 citations

Enhancement of erythrocyte superoxide dismutase activity: effects on cellular oxidant defense

1989 • 95 citations

Microsomal lipid peroxidation: Mechanisms of initiation

1989 • 90 citations

Advances in age pigment research

1991 • 90 citations

Excretion, Metabolism and Tissue Distribution of A Spin Trapping Agent, α-Phenyl-N-Tert-Butyl-Nitrone (Pbn) in Rats

1990 • 88 citations

A survey of chemicals inducing lipid peroxidation in biological systems

1987 • 84 citations

Chronic granulomatous disease.

1990 • 82 citations

Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo

1986 • 75 citations

Membrane proteins are critical targets in free radical mediated cytolysis

1988 • 69 citations

Effects of Oxidative Stress Caused by Hyperoxia and Diquat. A Study in Isolated Hepatocytes

1986 • 64 citations

The Molecular Genetics of Superoxide Dismutase inE. Coli. An Approach to Understanding the Biological Role and Regulation of Sods in Relation to Other Elements of the Defence System Against Oxygen Toxicity

1989 • 61 citations

The thiobarbituric acid-reactivity of bile pigments

1978 • 56 citations

Measurement of the diene conjugated form of linoleic acid in plasma by high performance liquid chromatography: A questionable non-invasive assay of free radical activity?

1985 • 55 citations

Human Fibroblasts Release Reactive Oxygen Species in Response to Treatment with Synovial Fluids from Patients Suffering from Arthritis

1990 • 55 citations

The presence of oxidative polymeric materials in encapsulated fish oils

1991 • 51 citations

Identification of a thioredoxin — related protein associated with plasma membranes

1991 • 50 citations

The Action of Hydrogen Peroxide on the Formation of Thiobarbituric Acid-Reactive Material From Microsomes, Liposomes Or From Dna Damaged By Bleomycin Or Phenanthroline. Artefacts in the Thiobarbituric Acid Test

1990 • 49 citations

Down syndrome clinical symptoms are manifested in transfected cells and transgenic mice overexpressing the human Cu/Zn-superoxide dismutase gene.

1990 • 48 citations

Lipid hydroperoxides permit deformation-dependent leak of monovalent cation from erythrocytes

1991 • 48 citations

Review Article the B Lymphocyte: A Newly Recognized Source of Reactive Oxygen Species with Immunoregulatory Potential

1990 • 47 citations

Lipid peroxidation of muscle food: the role of the cytosolic fraction

1991 • 44 citations

Chronic granulomatous disease

1991 • 41 citations

Measurement of Lipid Hydroperoxides in Normal Human Blood Plasma Using HPLC-Chemiluminescence Linked to a Diode Array Detector for Measuring Conjugated Dienes

1991 • 40 citations

Lipid hydroperoxides permit deformation-dependent leak of monovalent cation from erythrocytes

1991 • 39 citations

Hematin- and peroxide-catalyzed peroxidation of phospholipid liposomes

1991 • 39 citations

The Nature of the Primary Oxidants in Oxidations Mediated by Metal Ions

1982 • 39 citations

Gas chromatographic determination of malonaldehyde formed by lipid peroxidation

1989 • 38 citations

Quantitative determination of hydroxy fatty acids as an indicator of in vivo lipid peroxidation: Gas chromatography-mass spectrometry methods

1991 • 37 citations

Conjugated diene and trans fatty acids in tissue lipids of rats fed an hepatocarcinogenic choline-devoid diet

1990 • 34 citations

Studies of Hypervalent Iron

1991 • 34 citations

Spin Trapping and Associated Vocabulary

1990 • 31 citations

α-2,6-Difluorophenyl-N-Tert-Butylnitrone: A Spin Trap for Distinguishing Different Types of Alkyl Radicals Based on Long-Range Fluorine Hyperfine Splitting

1990 • 11 citations

Octadeca-9,11 Dienoic Acid - a Measurement of free Radical Activity or a Marker of Infection in the Lung?

1991 • 4 citations