Synaptic plasticity: LTP and LTD

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

1992 • 1,675 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation

1991 • 1,136 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus

1992 • 1,088 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

1991 • 1,016 citations

Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiation

1993 • 780 citations

Nitric Oxide and Synaptic Function

1994 • 779 citations

Comparison of Two Forms of Long-Term Potentiation in Single Hippocampal Neurons

1990 • 755 citations

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

1992 • 737 citations

Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

1993 • 736 citations

An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression

1993 • 678 citations

Possible involvement of nitric oxide in long-term potentiation

1991 • 637 citations

Mechanisms Underlying Long-Term Potentiation of Synaptic Transmission

1991 • 615 citations

Heterosynaptic depression: a postsynaptic correlate of long-term potentiation

1977 • 606 citations

Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus

1993 • 590 citations

Synapses as associative memory elements in the hippocampal formation

1979 • 573 citations

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

1993 • 562 citations

Storing covariance with nonlinearly interacting neurons

1977 • 558 citations

A Physiological Basis for a Theory of Synapse Modification

1987 • 535 citations

Common Forms of Synaptic Plasticity in the Hippocampus and Neocortex in Vitro

1993 • 485 citations

Long‐term potentiation and depression of synaptic responses in the rat hippocampus: localization and frequency dependency.

1978 • 470 citations

The role of nitric oxide in hippocampal long-term potentiation

1992 • 470 citations

Associative long-term depression in the hippocampus induced by hebbian covariance

1989 • 470 citations

Nitric oxide-induced blockade of NMDA receptors

1992 • 455 citations

Long-term synaptic depression in the mammalian brain

1994 • 432 citations

Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus.

1991 • 431 citations

NMDA application potentiates synaptic transmission in the hippocampus

1988 • 421 citations

A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation

1994 • 405 citations

Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.

1986 • 399 citations

Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices

1991 • 356 citations

Protein kinase C modulation of NMDA currents: an important link for LTP induction

1992 • 350 citations

The effects of repetitive low frequency stimulation on control and “potentiated” synaptic responses in the hippocampus

1980 • 315 citations

Stable depression of potentiated synaptic responses in the hippocampus with 1–5 Hz stimulation

1990 • 303 citations

Correlation between long‐term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats.

1986 • 289 citations

Long-term potentiation is associated with increases in quantal content and quantal amplitude

1992 • 288 citations

Quantal analysis and synaptic efficacy in the CNS

1991 • 287 citations

Homosynaptic long-term depression in the visual cortex

1994 • 285 citations

Presynaptic release probability influences the locus of long-term potentiation

1992 • 278 citations

Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by d(−)aminophosphonovalerate

1987 • 269 citations

Reversal of long-term potentiation by inhibitors of haem oxygenase

1993 • 265 citations

Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus

1993 • 262 citations

Temporal limits on the rise in postsynaptic calcium required for the induction of long-term potentiation

1992 • 258 citations

Platelet-activating factor as a potential retrograde messenger in CA1 hippocampal long-term potentiation

1994 • 251 citations

Ca2+ Entry via postsynaptic voltage-sensitive Ca2+ channels can transiently potentiate excitatory synaptic transmission in the hippocampus

1992 • 237 citations

Inhibition of Long-Term Potentiation by NMDA-Mediated Nitric Oxide Release

1992 • 233 citations

Characterization of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors.

1993 • 226 citations

Asynchronous pre- and postsynaptic activity induces associative long-term depression in area CA1 of the rat hippocampus in vitro.

1994 • 226 citations

Synaptic plasticity in rat hippocampal slice cultures: local "Hebbian" conjunction of pre- and postsynaptic stimulation leads to distributed synaptic enhancement.

1989 • 218 citations

Direct measurement of quantal changes underlying long-term potentiation in CA1 hippocampus

1992 • 218 citations

Short- and long-term synaptic depression in rat neostriatum

1993 • 205 citations

The suppression of long-term potentiation in rat hippocampus by inhibitors of nitric oxide synthase is temperature and age dependent

1993 • 204 citations

Quisqualate Metabotropic Receptors Modulate NMDA Currents and Facilitate Induction of Long‐Term Potentiation Through Protein Kinase C

1992 • 200 citations

Asymmetric relationships between homosynaptic long-term potentiation and heterosynaptic long-term depression

1983 • 196 citations

Priming of associative long-term depression in the dentate gyrus by θ frequency synaptic activity

1992 • 177 citations

Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation

1994 • 173 citations

Long‐term Depression Requires Nitric Oxide and Guanosine 3′:5’Cyclic Monophosphate Production in Rat Cerebellar Purkinje Cells

1993 • 170 citations

Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition

1991 • 168 citations

MCPG Antagonizes Metabotropic Glutamate Receptors but not Long‐term Potentiation in the Hippocampus

1994 • 166 citations

Learning-related synaptic plasticity: LTP and LTD

1991 • 165 citations

Cellular mechanisms of long-term depression in the cerebellum

1993 • 165 citations

Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: An in vivo study in the dentate gyrus of the rat

1989 • 153 citations

Dependence of long-term depression on postsynaptic metabotropic glutamate receptors in visual cortex.

1993 • 152 citations

Nitric oxide modulates NMDA-induced increases in intracellular Ca2+ in cultured rat forebrain neurons

1992 • 152 citations

A Role for Nitric Oxide in Long‐term Potentiation

1992 • 147 citations

Flip side of synaptic plasticity: Long‐term depression mechanisms in the hippocampus

1994 • 145 citations

Reversal of LTP by theta frequency stimulation

1993 • 144 citations

The role of Ca2+ entry via synaptically activated NMDA receptors in the induction of long-term potentiation

1993 • 140 citations

Isolated NMDA receptor-mediated synaptic responses express both LTP and LTD

1992 • 133 citations

Long‐term Depression of Glutamate Currents in Cultured Cerebellar Purkinje Neurons Does Not Require Nitric Oxide Signalling

1992 • 125 citations

Nitric oxide synthase-independent long-term potentiation in area CA1 of hippocampus

1993 • 123 citations

Priming of homosynaptic long-term depression in hippocampus by previous synaptic activity

1993 • 122 citations

The involvement of L-type calcium channels in heterosynaptic long-term depression in the hippocampus

1991 • 118 citations

(RS)-alpha-methyl-4-carboxyphenylglycine neither prevents induction of LTP nor antagonizes metabotropic glutamate receptors in CA1 hippocampal neurons

1993 • 114 citations

Nitric oxide synthase inhibitors block long-term potentiation induced by weak but not strong tetanic stimulation at physiological brain temperatures in rat hippocampal slices

1993 • 103 citations

Activation of metabotropic glutamate receptors induces long-term depression of GABAergic inhibition in hippocampus

1993 • 97 citations

Evidence for nitric oxide synthase inhibitor-sensitive and insensitive hippocampal synaptic potentiation

1992 • 95 citations

Nitric oxide and long-term synaptic depression in the rat hippocampus.

1993 • 91 citations

Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor

1994 • 88 citations

The postsynaptic induction of nonassociative long-term depression of excitatory synaptic transmission in rat hippocampal slices

1993 • 86 citations

Cognitive kinases.

1993 • 82 citations

Comparison of Excitatory Amino Acid‐Stimulated Phosphoinositide Hydrolysis and N‐[³H]Acetylaspartylglutamate Binding in Rat Brain: Selective Inhibition of Phosphoinositide Hydrolysis by 2‐Amino‐3‐Phosphonopropionate

1989 • 80 citations

Long-term depression in cerebral cortex: a possible substrate of “forgetting” that should not be forgotten

1993 • 71 citations

Heterosynaptic long-term depression is facilitated by blockade of inhibition in area CA1 of the hippocampus

1991 • 69 citations

Long-term depression at synapses in slices of rat hippocampus can be induced by bursts of postsynaptic activity

1990 • 63 citations

Long-term depression: not so depressing after all.

1993 • 58 citations

Antagonists of the Platelet‐activating Factor Receptor Block Long‐term Potentiation in Hippocampal Slices

1992 • 56 citations

Nitric oxide inhibitors facilitate the induction of hippocampal long-term potentiation by modulating NMDA responses

1993 • 52 citations

An antagonist of glutamate metabotropic receptors, (RS)-α-methyl-4-carboxyphenylglycine, prevents the LTP-related increase in postsynaptic AMPA sensitivity in hippocampal slices

1993 • 49 citations

Enhancement of AMPA‐mediated Synaptic Transmission by the Protein Phosphatase Inhibitor Calyculin A in Rat Hippocampal Slices

1993 • 48 citations

Lithium Treatment Blocks Long-Term Synaptic Depression in the Striatum

1993 • 42 citations

Transient heterosynaptic depression in the hippocampal slice

1978 • 40 citations

Further studies concerning the role of nitric oxide in LTP induction and maintenance

1993 • 38 citations

Stimulation of Phosphoinositide Turnover by Excitatory Amino Acids

1991 • 34 citations

Comparison of associative and non‐associative conditioning procedures in the induction of LTD in CA1 of the hippocampus

1993 • 33 citations

The search for retrograde messengers in long-term potentiation

1993 • 32 citations

Failure to Induce Long-term Depression by an Anti-Correlation Procedure in Area CA1 of the Rat Hippocampal Slice

1993 • 32 citations

Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus

1993 • 27 citations

Activity-dependent enhancement of synaptic transmission in hippocampal slices treated with the phosphatase inhibitor calyculin A

1994 • 25 citations

d-2-amino-5-phosphonovaleate blocks induction of long-term depression of the NMDA receptor-mediated synaptic component in rat hippocampus

1993 • 24 citations

Selective inhibition of homosynaptic depression in a tetanized pathway by an adenosine A1 blocker in the CA1 region of rat hippocampal slice

1992 • 14 citations

Presynaptic mechanism for heterosynaptic, posttetanic depression in area CA1 of rat hippocampus

1993 • 11 citations

2,3-Diphosphoglycerate Content of Human Arterial and Venous Blood

1971 • 10 citations

A prolonged post-tetanic hyperpolarization in rat hippocampal pyramidal cells in vitro

1990 • 9 citations

Going down the way you came up

1993 • 4 citations