Is Schizophrenia a Progressive Neurodevelopmental Disorder? Toward a Unitary Pathogenetic Mechanism

Implications of Normal Brain Development for the Pathogenesis of Schizophrenia

1987 • 3,683 citations

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

1991 • 3,275 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

A Quantitative Magnetic Resonance Imaging Study of Changes in Brain Morphology From Infancy to Late Adulthood

1994 • 1,385 citations

Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?

1982 • 1,352 citations

CEREBRAL VENTRICULAR SIZE AND COGNITIVE IMPAIRMENT IN CHRONIC SCHIZOPHRENIA

1976 • 1,235 citations

Morphometric study of human cerebral cortex development

1990 • 1,223 citations

Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia

1992 • 1,173 citations

A clinicopathological study of autism

1998 • 1,061 citations

Quantitative Magnetic Resonance Imaging of Human Brain Development: Ages 4–18

1996 • 1,036 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Abnormally High Neuronal Density in the Schizophrenic Cortex

1995 • 866 citations

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

1996 • 745 citations

Altered Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Cells in Frontal Lobe of Schizophrenics Implies Disturbances of Cortical Development

1993 • 660 citations

Aging and Extrapyramidal Function

1977 • 650 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

From neuropathology to neurodevelopment

1995 • 569 citations

Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics

1990 • 558 citations

A Follow-up Magnetic Resonance Imaging Study of Schizophrenia

1998 • 542 citations

Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia

1997 • 517 citations

Is Schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited

1994 • 507 citations

Quantitative Cytoarchitectural Studies of the Cerebral Cortex of Schizophrenics

1986 • 506 citations

HEMIPLEGIA OF EARLY ONSET AND THE FACULTY OF SPEECH WITH SPECIAL REFERENCE TO THE EFFECTS OF HEMISPHERECTOMY

1962 • 476 citations

Neuropathology of Schizophrenia

1982 • 472 citations

Distorted Distribution of Nicotinamide-Adenine Dinucleotide Phosphate—Diaphorase Neurons in Temporal Lobe of Schizophrenics Implies Anomalous Cortical Development

1993 • 449 citations

MATURATION OF HUMAN CEREBRUM OBSERVED IN VIVO DURING ADOLESCENCE

1991 • 448 citations

Macrocephaly in Children and Adults With Autism

1997 • 443 citations

Limbic pathology in schizophrenia: The entorhinal region—a morphometric study

1988 • 441 citations

Myelination of Cortical-hippocampal Relays During Late Adolescence

1989 • 439 citations

Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia

1992 • 421 citations

An MRI study of brain size in autism

1995 • 417 citations

Obstetric Complications and Schizophrenia: A Meta-Analysis

1995 • 404 citations

The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method.

1991 • 393 citations

Maldistribution of Interstitial Neurons in Prefrontal White Matter of the Brains of Schizophrenic Patients

1996 • 391 citations

Discussion

1997 • 373 citations

Brain morphology in first-episode schizophrenic-like psychotic patients: A quantitative magnetic resonance imaging study

1991 • 365 citations

Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine

1995 • 357 citations

Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood

1997 • 343 citations

Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum

1997 • 333 citations

Regional Brain Abnormalities in Schizophrenia Measured With Magnetic Resonance Imaging

1994 • 318 citations

Is it really better to have your brain lesion early? a revision of the “Kennard Principle”

1979 • 288 citations

Schizophrenia and the brain: a prospective clinico-neuropathological study

1990 • 287 citations

Absence of regional hemispheric volume asymmetries in first-episode schizophrenia

1994 • 277 citations

Functional development of the prefrontal cortex in early life and the problem of neuronal plasticity

1971 • 274 citations

Magnetic Resonance Imaging Abnormalities in Lenticular Nuclei and Cerebral Cortex in Schizophrenia

1991 • 271 citations

Plasticity in the neocortex: mechanisms underlying recovery from early brain damage

1989 • 265 citations

Inactivation of bcl-2 Results in Progressive Degeneration of Motoneurons, Sympathetic and Sensory Neurons during Early Postnatal Development

1996 • 263 citations

A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: Preliminary findings

1995 • 263 citations

CORTICAL REORGANIZATION OF MOTOR FUNCTION

1942 • 251 citations

Childhood-Onset Schizophrenia

1997 • 250 citations

Volumes of Ventricular System Subdivisions Measured From Magnetic Resonance Images in First-Episode Schizophrenic Patients

1992 • 225 citations

Reduction of cortical volume in schizophrenia on magnetic resonance imaging

1993 • 222 citations

DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

1995 • 221 citations

The Genetics of Schizophrenia is the Genetics of Neurodevelopment

1991 • 218 citations

Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors

1993 • 208 citations

Recent advances in defining the neuropathology of schizophrenia

1996 • 206 citations

Schizophrenia: A Neuropathological Perspective

1991 • 206 citations

Ventricular Enlargement in Poor-Outcome Schizophrenia

1998 • 203 citations

Stability of CT scan findings in schizophrenia: results of an 8 year follow-up study.

1988 • 201 citations

A morphometric study of the dopamine-containing cell groups in the mesencephalon of normals, Parkinson patients, and schizophrenics.

1983 • 197 citations

The effect of early and late brain injury upon test scores, and the nature of adult intelligence.

1942 • 185 citations

Meta-analysis of brain and cranial size in schizophrenia

1996 • 183 citations

Pervasive neuroanatomic abnormalities of the brain in three cases of Rett's syndrome

1995 • 172 citations

Prefrontal Cortex and Schizophrenia

1995 • 170 citations

Cerebral Ventricular Enlargement in Schizophrenia

1986 • 158 citations

Is there gliosis in schizophrenia? Investigation of the temporal lobe

1987 • 153 citations

Is schizophrenia a lifetime disorder of brain plasticity, growth and aging?

1997 • 152 citations

Gliosis in schizophrenia: A survey

1986 • 150 citations

Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging.

1997 • 149 citations

Clinical subtypes of schizophrenia: differences in brain and CSF volume

1994 • 148 citations

Brain morphology in first-episode schizophrenia

1995 • 147 citations

Progressive ventricular enlargement in schizophrenia: Comparison to bipolar affective disorder and correlation with clinical course

1990 • 146 citations

Etiology of Autism: Genetic Influences

1991 • 146 citations

Neuroanatomy in Rett syndrome

1997 • 138 citations

Brain morphology in schizophrenia: a 2‐ to 5‐year CT scan follow‐up study

1988 • 132 citations

Rett syndrome: A disorder affecting early brain growth

1997 • 132 citations

Genetic variation in vulnerability to the behavioral effects of neonatal hippocampal damage in rats.

1995 • 132 citations

Developmental Brain Abnormalities in the Offspring of Schizophrenic Mothers

1994 • 111 citations

Magnetic Resonance Imaging in Schizophrenia

1991 • 108 citations

The role of stress and dopamine-GABA interactions in the vulnerability for schizophrenia

1997 • 105 citations

Cerebral ventricular enlargement in schizophreniform disorder does not progress A seven year follow-up study

1994 • 101 citations

Computed tomography (CT) findings in schizophrenia: Speculation on the meaning of it all

1984 • 93 citations

Early onset of complementary specialization of cerebral hemispheres in man.

1973 • 93 citations

Neurology of developmental dyslexia

1993 • 84 citations

Ventricle-to-brain ratio in schizophrenia: a controlled follow-up study

1989 • 83 citations

Pathological reaction of astrocytes in perinatal brain injury

1986 • 79 citations

MRI brain abnormalities in chronic schizophrenia: One process or more?

1996 • 77 citations

Gray matter deficits in young onset schizophrenia are independent of age of onset

1996 • 70 citations

Stability of ventricular size after the onset of psychosis in schizophrenia

1991 • 68 citations

Quantitative study of gliosis in schizophrenia and huntington's chorea

1988 • 66 citations

Stability of cerebral ventricular size from the appearance of the first psychotic symptoms to the later diagnosis of schizophrenia

1994 • 63 citations

A reconsideration of the relation of ventricular enlargement to duration of illness in schizophrenia

1983 • 59 citations

Schizophrenia as a progressive disorder: Relations to EEG, CT. neuropathological and other evidence

1989 • 45 citations

Three-year follow-up of older schizophrenics: Extrapyramidal syndromes, psychiatric symptoms, and ventricular brain ratio

1991 • 40 citations

Magnetic resonance imaging in schizophrenia

1996 • 31 citations

Rett Syndrome Studies of Natural History and Search for a Genetic Marker

1995 • 31 citations

14. Brain volume loss in schizophrenia: When does it occur and is it progressive?

1991 • 27 citations