Kainic acid induces apoptosis in neurons

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Guam Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Linked to a Plant Excitant Neurotoxin

1987 • 881 citations

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

1995 • 744 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

1993 • 623 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons

1994 • 588 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Calpain activation in apoptosis

1994 • 445 citations

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

1988 • 437 citations

Kainate-induced apoptotic cell death in hippocampal neurons

1994 • 404 citations

Membrane fusion machinery: Insights from synaptic proteins

1993 • 380 citations

Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.

1994 • 291 citations

Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells.

1994 • 271 citations

The role of estrogens on the proliferation of human breast tumor cells (MCF-7)

1985 • 257 citations

Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX

1994 • 238 citations

Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain

1993 • 235 citations

Apoptosis: the biochemistry and molecular biology of programmed cell death

1993 • 222 citations

Neurotoxicity ofβ-N-methylamino-l-alanine (BMAA) andβ-N-oxalylamino-l-alamine (BOAA) on cultured cortical neurons

1989 • 206 citations

The mechanism of T cell mediated cytotoxicity II. morphological studies of cell death by time-lapse microcinematography

1976 • 146 citations

DNA fragmentation in rat brain after intraperitoneal administration of kainate

1994 • 136 citations

The inhibition of nucleic acid-binding proteins by aurintricarboxylic acid

1973 • 125 citations

Cytosolic free Ca2+ and proteolysis in lethal oxidative injury in endothelial cells

1991 • 113 citations

Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose

1991 • 110 citations

Cytokine-induced programmed death of cultured sympathetic neurons

1993 • 102 citations

Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells

1993 • 99 citations

The biochemical mechanisms of the excitotoxicity of Kainic acid

1992 • 95 citations

Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures.

1991 • 84 citations

Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins

1990 • 80 citations

Basal forebrain cholinergic neurons are selectively vulnerable to AMPA/kainate receptor-mediated neurotoxicity

1994 • 62 citations

Inhibition of RNA-directed DNA polymerase by aurintricarboxylic acid.

1976 • 50 citations

Dissociation of nitric oxide generation and kainate-mediated neuronal degeneration in primary cultures of rat cerebellar granule cells

1992 • 50 citations

Aurintricarboxylic Acid Prevents NMDA‐Mediated Excitotoxicity: Evidence for Its Action as an NMDA Receptor Antagonist

1993 • 46 citations

Aurintricarboxylic Acid, a Preferential Inhibitor of Initiation of Protein Synthesis

1971 • 34 citations

Excitotoxicity at Both NMDA and Non‐NMDA Glutamate Receptors Is Antagonized by Aurintricarboxylic Acid: Evidence for Differing Mechanisms of Action

1995 • 17 citations