Evidence for Activation of Caspase‐3‐Like Protease in Excitotoxin‐ and Hypoxia/Hypoglycemia‐Injured Neurons

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

Caspases: killer proteases

1997 • 2,440 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

1993 • 703 citations

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models

1995 • 604 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

A cautionary note on the use of the TUNEL stain to determine apoptosis

1995 • 490 citations

Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain

1993 • 481 citations

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

1988 • 437 citations

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1996 • 427 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Inhibition of proteolysis protects hippocampal neurons from ischemia.

1991 • 363 citations

Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum

1997 • 333 citations

Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species

1996 • 324 citations

Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain

1994 • 314 citations

Early Detection of DNA Strand Breaks in the Brain After Transient Focal Ischemia: Implications for the Role of DNA Damage in Apoptosis and Neuronal Cell Death

1997 • 312 citations

N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.

1987 • 309 citations

Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis

1997 • 284 citations

Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro

1995 • 258 citations

Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain

1993 • 235 citations

Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease

1996 • 211 citations

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat

1996 • 207 citations

Neuroprotective Effects of Glutamate Antagonists and Extracellular Acidity

1993 • 202 citations

Glutamate‐Induced Neuronal Death Is Not a Programmed Cell Death in Cerebellar Culture

1993 • 160 citations

Caspase Inhibition Selectively Reduces the Apoptotic Component of Oxygen-Glucose Deprivation-Induced Cortical Neuronal Cell Death

1997 • 151 citations

P1 Aspartate-Based Peptide .alpha.-((2,6-Dichlorobenzoyl)oxy)methyl Ketones as Potent Time-Dependent Inhibitors of Interleukin-1.beta.-Converting Enzyme

1994 • 147 citations

In situ detection of DNA fragmentation after focal cerebral ischemia in mice

1995 • 137 citations

DNA fragmentation in rat brain after intraperitoneal administration of kainate

1994 • 136 citations

DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat

1995 • 135 citations

Characterization of CPP32‐Like Protease Activity Following Apoptotic Challenge in SH‐SY5Y Neuroblastoma Cells

1997 • 96 citations

Cloning and Expression of a Rat Brain Interleukin-1β-Converting Enzyme (ICE)-Related Protease (IRP) and Its Possible Role in Apoptosis of Cultured Cerebellar Granule Neurons

1997 • 92 citations

A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices

1991 • 87 citations

Glutamate-Treated Rat Cortical Neuronal Cultures Die in a Way Different from the Classical Apoptosis Induced by Staurosporine

1997 • 64 citations

Glutamate Neurotoxicity Is Independent of Calpain I Inhibition in Primary Cultures of Cerebellar Granule Cells

1991 • 59 citations

Cell death in perinatal hypoxic–ischaemic brain injury

1997 • 55 citations

AMPA receptors in cerebellar granule cells during development in culture

1995 • 37 citations

Phenytoin pretreatment prevents hypoxic-ischemic brain damage in neonatal rats

1996 • 34 citations