An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors.

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Molecular diversity of the NMDA receptor channel

1992 • 1,354 citations

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1994 • 1,342 citations

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

1993 • 828 citations

Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes.

1995 • 440 citations

The Majority ofN-Methyl-d-Aspartate Receptor Complexes in Adult Rat Cerebral Cortex Contain at Least Three Different Subunits (NR1/NR2A/NR2B)

1997 • 385 citations

Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors

1992 • 261 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.

1988 • 237 citations

A novel mechanism of activity‐dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.

1996 • 230 citations

Multiple Structural Elements Determine Subunit Specificity of Mg²⁺Block in NMDA Receptor Channels

1996 • 228 citations

Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits.

1994 • 219 citations

Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule.

1994 • 190 citations

Preferential co-assembly of recombinant NMDA receptors composed of three different subunits

1993 • 190 citations

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.

1988 • 189 citations

(1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: A Potent New Neuroprotectant Which Blocks N-Methyl-D-Aspartate Responses

1995 • 179 citations

Interactions between Ifenprodil and the NR2B Subunit of the N-Methyl-D-aspartate Receptor

1996 • 159 citations

Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors

1995 • 143 citations

Separation of .alpha.1-adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds

1991 • 139 citations

Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons.

1994 • 132 citations

Ifenprodil blocks N-methyl-D-aspartate receptors by a two-component mechanism.

1991 • 127 citations

Stoichiometry of Recombinant N-Methyl-<scp>d</scp>-Aspartate Receptor Channels Inferred from Single-channel Current Patterns

1997 • 119 citations

Functional consequences of NR2 subunit composition in single recombinant N -methyl- <scp>d</scp> -aspartate receptors

1997 • 114 citations

Cell surface expression of the human N-methyl-d-aspartate receptor subunit 1a requires the co-expression of the NR2A subunit in transfected cells

1996 • 94 citations

Pentameric subunit stoichiometry of a neuronal glutamate receptor.

1996 • 94 citations

Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.

1996 • 88 citations

NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology.

1997 • 87 citations

An aspartate residue in the extracellular loop of the N-methyl-D-aspartate receptor controls sensitivity to spermine and protons.

1996 • 83 citations

Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition.

1997 • 80 citations

Single channel properties of cloned NMDA receptors in a human cell line: comparison with results from Xenopus oocytes.

1994 • 79 citations

Pharmacological Characterization of Heterodimeric NMDA Receptors Composed of NR 1a and 2B Subunits: Differences with Receptors Formed from NR 1a and 2A

1995 • 69 citations

Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits.

1996 • 64 citations

The NR2B-specific Interactions of Polyamines and Protons with theN-Methyl-d-aspartate Receptor

1997 • 62 citations

Influence of extracellular pH on inhibition by ifenprodil at N-methyl-d-aspartate receptors in Xenopus oocytes

1997 • 56 citations

Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes

1996 • 54 citations

Inhibition of N-methyl-D-aspartate receptors by haloperidol: developmental and pharmacological characterization in native and recombinant receptors.

1996 • 50 citations

Characterization of haloperidol and trifluperidol as subtype-selective N-methyl-D-aspartate (NMDA) receptor antagonists using [3H]TCP and [3H]ifenprodil binding in rat brain membranes.

1997 • 39 citations

Modulation of the N‐Methyl‐<scp>d</scp>‐Aspartate Receptor by Haloperidol: NR2B‐Specific Interactions

1998 • 31 citations

Stable transfection of the NR1 subunit in Chinese hamster ovary cells fails to produce a functional receptor

1994 • 30 citations