The neural cell adhesion molecule and synaptic plasticity

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Developmental mechanisms that generate precise patterns of neuronal connectivity

1993 • 1,435 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning

1994 • 1,010 citations

Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation

1993 • 841 citations

Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule.

1983 • 635 citations

Regulation of growth cone behavior by calcium

1991 • 597 citations

Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin

1994 • 594 citations

Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice

1984 • 531 citations

Brief bursts of high-frequency stimulation produce two types of structural change in rat hippocampus.

1980 • 474 citations

Genetic analysis of growth cone guidance in drosophila: Fasciclin II functions as a neuronal recognition molecule

1991 • 464 citations

Long-lasting morphological changes in dendritic spines of dentate granular cells following stimulation of the entorhinal area

1977 • 450 citations

Neural cell adhesion molecules influence second messenger systems

1989 • 387 citations

Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia

1992 • 377 citations

Adult and embryonic mouse neural cell adhesion molecules have different binding properties

1983 • 350 citations

Normal aging: regionally specific changes in hippocampal synaptic transmission

1994 • 332 citations

N-cadherin, NCAM, and integrins promote retinal neurite outgrowth on astrocytes in vitro.

1988 • 326 citations

Polysialic acid as a regulator of intramuscular nerve branching during embryonic development

1990 • 319 citations

Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia

1992 • 313 citations

The 180-kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeleton-membrane interactions

1987 • 303 citations

Alterations in neural cell adhesion molecules during development of different regions of the nervous system

1984 • 302 citations

Neurite outgrowth in response to transfected N-CAM changes during development and is modulated by polysialic acid

1990 • 299 citations

Studies of adhesion molecules mediating interactions between cells of peripheral nervous system indicate a major role for L1 in mediating sensory neuron growth on Schwann cells in culture.

1988 • 288 citations

Synaptic correlates of associative potentiation/depression: an ultrastructural study in the hippocampus

1983 • 278 citations

Spatial dynamics of second messengers: IP3 and cAMP as long-range and associative messengers

1994 • 264 citations

Molecular Mechanisms of Axon Growth and Guidance

1991 • 263 citations

Differentiation state-dependent surface mobilities of two forms of the neural cell adhesion molecule

1986 • 262 citations

A threshold effect of the major isoforms of NCAM on neurite outgrowth

1990 • 260 citations

Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules

1994 • 242 citations

Target-Dependent Structural Changes Accompanying Long-Term Synaptic Facilitation in Aplysia Neurons

1990 • 230 citations

Polysialic acid influences specific pathfinding by avian motoneurons

1992 • 229 citations

Hippocampus, theta, and spatial memory

1993 • 227 citations

A sensory role for neuronal growth cone filopodia

1993 • 223 citations

Neurite growth on different substrates: permissive versus instructive influences and the role of adhesive strength

1992 • 217 citations

Changes in the postsynaptic density with long‐term potentiation in the dentate gyrus

1986 • 206 citations

A role for the neural cell adhesion molecule in a late, consolidating phase of glycoprotein synthesis six hours following passive avoidance training of the young chick

1993 • 192 citations

Structure of a new nervous system glycoprotein, Nr-CAM, and its relationship to subgroups of neural cell adhesion molecules.

1991 • 190 citations

Response of sensory neurites and growth cones to patterned substrata of laminin and fibronectin in vitro

1987 • 182 citations

Neurite outgrowth in response to transfected N-CAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMs

1991 • 178 citations

Characterisation of the second messenger pathway underlying neurite outgrowth stimulated by FGF

1994 • 163 citations

Regulation of axonal growth in the vertebrate nervous system by interactions between glycoproteins belonging to two subgroups of the immunoglobulin superfamily.

1992 • 161 citations

Transfected F3/F11 neuronal cell surface protein mediates intercellular adhesion and promotes neurite outgrowth

1991 • 151 citations

The VASE exon downregulates the neurite growth-promoting activity of NCAM 140

1992 • 145 citations

The Production of Arachidonic Acid Can Account for Calcium Channel Activation in the Second Messenger Pathway Underlying Neurite Outgrowth Stimulated by NCAM, N‐Cadherin, and L1

1994 • 144 citations

Hippocampal NCAM180 transiently increases sialylation during the acquisition and consolidation of a passive avoidance response in the adult rat

1992 • 143 citations

Tyrosine kinase inhibitors can differentially inhibit integrin-dependent and CAM-stimulated neurite outgrowth

1994 • 126 citations

Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats

1994 • 125 citations

Expression of the unique NCAM VASE exon is independently regulated in distinct tissues during development.

1990 • 110 citations

Cell Type‐specific Effects of the Neural Adhesion Molecules L1 and N‐CAM on Diverse Second Messenger Systems

1992 • 106 citations

Development of hippocampal long-term potentiation is reduced by recently introduced calpain inhibitors

1990 • 102 citations

Structure and function of the gene for neural cell adhesion molecule

1991 • 87 citations

Glycoproteins that regulate the growth and guidance of vertebrate axons: domains and dynamics of the immunoglobulin/fibronectin type III subfamily

1991 • 82 citations

Tissue specific O-linked glycosylation of the neural cell adhesion molecule (N-CAM)

1989 • 76 citations

A developmentally regulated switch in neuronal responsiveness to NCAM and N-cadherin in the rat hippocampus

1992 • 65 citations

Expression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum.

1994 • 62 citations

Long-term Facilitation in Aplysia: Persistent Phosphorylation and Structural Changes

1990 • 59 citations

Nerve dependent regulation of neural cell adhesion molecule expression in skeletal muscle

1986 • 58 citations

The mouse NCAM gene displays a biphasic expression pattern during neural tube development

1993 • 55 citations

Calcium-activated proteolysis of intracellular domains in the cell adhesion molecules NCAM and N-cadherin

1991 • 51 citations

Alternative Splicing of the Cytoplasmic Domain of Neural Cell Adhesion Molecule Alters Its Ability to Act as a Substrate for Neurite Outgrowth

1992 • 50 citations

Proteolytic modification of neural cell adhesion molecule (NCAM) by the intracellular proteinase calpain

1991 • 42 citations

Use of the Neural Cell Adhesion Molecule VASE Exon by Neurons Is Associated with a Specific Down‐Regulation of Neural Cell Adhesion Molecule‐Dependent Neurite Outgrowth in the Developing Cerebellum and Hippocampus

1992 • 42 citations

Axon growth is enhanced by NCAM lacking the VASE exon when expressed in either the growth substrate or the growing axon

1993 • 40 citations

Characterisation and Regional Localisation of Pre‐ and Postsynaptic Glycoproteins of the Chick Forebrain Showing Changed Fucose Incorporation Following Passive Avoidance Training

1992 • 39 citations

Neurite Outgrowth Stimulated by L1 Requires Calcium Influx into Neurons but is Not Associated with Changes in Steady State Levels of Calcium in Growth Cones

1994 • 34 citations

Increased efflux of a haemoglobin-like protein and an 80 kDa protease into push-pull perfusates following the induction of long-term potentiation in the dentate gyrus

1990 • 20 citations

Pleiotropic biological effects of the neural cell adhesion molecule (NCAM)

1991 • 14 citations

The biochemistry of memory.

1991 • 7 citations

Glycoproteins modulate changes in synaptic connectivity in memory formation

1992 • 4 citations