The TINS/TiPS Lecture the molecular biology of mammalian glutamate receptor channels

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Ca2 ⁺ Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

1991 • 1,458 citations

A Family of AMPA-Selective Glutamate Receptors

1990 • 1,453 citations

Molecular diversity of the NMDA receptor channel

1992 • 1,354 citations

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

1990 • 1,234 citations

Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit

1992 • 1,077 citations

Modulation of Neuronal Migration by NMDA Receptors

1993 • 1,034 citations

Cloning by functional expression of a member of the glutamate receptor family

1989 • 1,009 citations

Light and electron immunocytochemical localization of AMPA‐selective glutamate receptors in the rat brain

1992 • 988 citations

Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits.

1993 • 978 citations

Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes

1990 • 925 citations

Structure-activity relationships in the development of excitatory ammo acid receptor agonists and competitive antagonists

1990 • 905 citations

Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system

1990 • 872 citations

Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels

1991 • 827 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

1992 • 805 citations

Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability

1991 • 774 citations

Developmental changes in distribution of NMDA receptor channel subunit mRNAs

1992 • 718 citations

Cloning of a novel glutamate receptor subunit, GluR5: Expression in the nervous system during development

1990 • 646 citations

Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

1991 • 638 citations

Zinc potentiates agonist-lnduced currents at certain splice variants of the NMDA receptor

1993 • 605 citations

A family of glutamate receptor genes: Evidence for the formation of heteromultimeric receptors with distinct channel properties

1990 • 581 citations

Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents

1990 • 570 citations

Glutamate-operated channels: Developmentally early and mature forms arise by alternative splicing

1991 • 560 citations

Cellular localization of a metabotropic glutamate receptor in rat brain

1992 • 539 citations

The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits

1992 • 537 citations

AMPA receptor subunits expressed by single purkinje cells

1992 • 524 citations

Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing

1992 • 521 citations

Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones.

1990 • 498 citations

Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells

1991 • 461 citations

Glutamate receptor desensitization and its role in synaptic transmission

1989 • 459 citations

Determinants of ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: Diversity by RNA editing

1993 • 453 citations

Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA Receptor

1992 • 437 citations

Molecular Neurobiology of Glutamate Receptors

1992 • 436 citations

Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices.

1992 • 435 citations

Glutamate receptor channels: novel properties and new clones

1992 • 427 citations

Glutamate receptor channels in rat DRG neurons: Activation by kainate and quisqualate and blockade of desensitization by con A

1990 • 420 citations

Calcium-Permeable AMPA-Kainate Receptors in Fusiform Cerebellar Glial Cells

1992 • 413 citations

Cloning of a putative glutamate receptor: A low affinity kainate-binding subunit

1992 • 379 citations

GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses

1993 • 359 citations

A glutamate receptor channel with high affinity for domoate and kainate.

1992 • 336 citations

Calcium Entry Through Kainate Receptors and Resulting Potassium-Channel Blockade in Bergmann Glial Cells

1992 • 334 citations

The rat delta‐1 and delta‐2 subunits extend the excitatory amino acid receptor family

1993 • 330 citations

Mammalian ionotropic glutamate receptors

1993 • 312 citations

Liquid filament switch for ultra-fast exchanges of solutions at excised patches of synaptic membrane of crayfish muscle

1987 • 297 citations

Cloning and expression of the ε4 subunit of the NMDA receptor channel

1992 • 296 citations

Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase

1993 • 294 citations

Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal slices.

1992 • 272 citations

Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex.

1992 • 268 citations

Identification by mutagenesis of a Mg2+ -block site of the NMDA receptor channel

1992 • 264 citations

Kinetic analysis of interactions between kainate and AMPA: Evidence for activation of a single receptor in mouse hippocampal neurons

1991 • 263 citations

Quisqualate‐ and kainate‐activated channels in mouse central neurones in culture.

1988 • 199 citations

Molecular cloning and development analysis of a new glutamate receptor subunit isoform in cerebellum

1992 • 194 citations

Structural determinants of barium permeation and rectification in non- NMDA glutamate receptor channels

1992 • 180 citations

Primary structure and expression of the γ2 subunit of the glutamate receptor channel selective for kainate

1992 • 173 citations

Alteration of Ca2+ permeability and sensitivity to Mg2+ and channel blockers by a single amino acid substitution in the N-methyl-D-aspartate receptor.

1993 • 155 citations

Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family

1992 • 145 citations

High‐affinity kainate a domoate receptors in rat brain

1992 • 135 citations