Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

The choice of cell fate in the epidermis of Drosophila

1991 • 736 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

1995 • 669 citations

Current protocols in immunology

1993 • 551 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Selective Events in T Cell Development

1994 • 486 citations

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

1987 • 483 citations

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

1994 • 426 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Differential expression of two distinct T-cell receptors during thymocyte development

1987 • 360 citations

Notch2: a second mammalian Notch gene

1992 • 346 citations

A homolog of Drosophila Notch expressed during mammalian development

1991 • 338 citations

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

1994 • 318 citations

Xotch , the Xenopus Homolog of Drosophila Notch

1990 • 303 citations

Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision

1994 • 254 citations

Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development

1992 • 253 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Self-reactive γδ T cells are eliminated in the thymus

1990 • 221 citations

Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.

1996 • 210 citations

Different Levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates

1995 • 200 citations

The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.

1995 • 165 citations

Modulated expression of notch1 during thymocyte development

1996 • 147 citations

α β and γ δ T cells can share a late common precursor

1995 • 139 citations

Motch A and Motch B—Two Mouse Notch Homologues Coexpressed in a Wide Variety of Tissues

1993 • 136 citations

In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision

1995 • 122 citations

Commitment to the T cell receptor‐αβ or ‐γδ lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes

1992 • 110 citations

Control of γδ T‐Cell Development

1991 • 93 citations

Self-tolerance to transgenic γδ T cells by intrathymic inactivation

1990 • 87 citations

T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway

1990 • 79 citations

Positive selection is not required for thymic maturation of transgenic gamma delta T cells.

1996 • 66 citations

Repertoire Development and Ligand Specificity of Murine TCRγδ Cells

1991 • 64 citations

γδ T-cell development

1993 • 61 citations

The T-cell antigen receptor gamma gene: rearrangement and cell lineages

1987 • 59 citations

Evidence that productive rearrangements of TCR γ genes influence the commitment of progenitor cells to differentiate into αβ or γδ T cells

1995 • 52 citations

Commitment and maintenance of the alpha beta and gamma delta T cell lineages.

1995 • 40 citations

Efficient maturation of alpha beta lineage thymocytes to the CD4+CD8+ stage in the absence of TCR-beta rearrangement.

1995 • 36 citations

_γδ T cells promote CD4 and CD8 expression by SCID thymocytes

1993 • 35 citations