Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Illegitimate transcription: transcription of any gene in any cell type.

1989 • 647 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

Identification of a Thymic Epithelial Cell Subset Sharing Expression of the Class Ib HLA-G Molecule with Fetal Trophoblasts

1997 • 296 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Intrathymic and extrathymic clonal deletion of T cells

1995 • 201 citations

Thymic expression of autoantigens correlates with resistance to autoimmune disease.

1997 • 193 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium

1998 • 162 citations

Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease

1998 • 155 citations

Tolerance induction by thymic medullary epithelium.

1992 • 121 citations

Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?

1998 • 114 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

Peripheral Tolerance as a Multi‐Step Mechanism

1993 • 97 citations

CD4 T Cell Tolerance to Nuclear Proteins Induced by Medullary Thymic Epithelium

1996 • 83 citations

Peripheral tolerance of CD4 T cells following local activation in adolescent mice

1996 • 82 citations

Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages

1998 • 78 citations

Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein

1995 • 74 citations

The molecular biology of olfactory perception.

1996 • 62 citations

Thymic expression of myelin basic protein (MBP). Activation of MBP-specific T cells by thymic cells in the absence of exogenous MBP.

1996 • 59 citations

T-cell tolerance

1993 • 55 citations

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1997 • 55 citations

An acetylcholine receptor alpha subunit promoter confers intrathymic expression in transgenic mice. Implications for tolerance of a transgenic self-antigen and for autoreactivity in myasthenia gravis.

1998 • 49 citations

Induction of tolerance to self MHC class I molecules expressed under the control of milk protein or β-globin gene promoters

1994 • 48 citations

A Novel Transcript Overlapping the Myelin Basic Protein Gene

1992 • 43 citations

Expression of major histocompatibility complex class I antigens at low levels in the thymus induces T cell tolerance via a non‐deletional mechanism

1992 • 42 citations

Aberrant Expression of Tissue‐Specific Proteins in the Thymus: A Hypothesis for the Development of Central Tolerance

1998 • 39 citations

The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus

1997 • 35 citations

Tolerance and MHC restriction in transgenic mice expressing a MHC class I gene in erythroid cells

1992 • 35 citations

Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages

1998 • 29 citations

Homeostatic mechanisms in the control of autoimmunity

1997 • 20 citations

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