Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos

1975 • 966 citations

Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development

1993 • 908 citations

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

1991 • 856 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

Dependence of Thymus Development on Derivatives of the Neural Crest

1984 • 463 citations

The thymic microenvironment

1993 • 459 citations

Tracing of cells of the avian thymus through embryonic life in interspecific chimeras.

1975 • 409 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

Morphogenetic interactions in the development of the mouse thymus gland

1960 • 336 citations

Mendelian inheritance in man

1991 • 304 citations

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

TISSUE INTERACTION IN THE DEVELOPMENT OF THYMUS LYMPHOCYTES

1969 • 295 citations

Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme.

1987 • 271 citations

Epiregulin

1995 • 265 citations

Development of thymus, parathyroids, and ultimo‐branchial bodies in NMRI and nude mice

1980 • 264 citations

Epidermal growth factor or transforming growth factor alpha is required for kidney tubulogenesis in matrigel cultures in serum-free medium.

1990 • 243 citations

T-Cell Differentiation is Influenced by Thymic Microenvironments

1991 • 239 citations

Ductal morphogenesis in the mouse mammary gland: Evidence supporting a role for epidermal growth factor

1988 • 232 citations

Epithelial-mesenchymal interactions are required formsx 1andmsx 2gene expression in the developing murine molar tooth

1993 • 224 citations

TGF-β1 influences the relative development of the exocrine and endocrine pancreas in vitro

1994 • 215 citations

Role of mesenchymal nidogen for epithelial morphogenesis in vitro

1994 • 215 citations

Disorganization and restoration of thymic medullary epithelial cells in T cell receptor‐negative scid mice: Evidence that receptor‐bearing lymphocytes influence maturation of the thymic microenvironment

1991 • 190 citations

Local effects of EGF, α‐TGF, and EGF‐like growth factors on lobuloalveolar development of the mouse mammary gland in vivo

1987 • 147 citations

Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction

1993 • 138 citations

Substitution for mesenchyme by basement-membrane-like substratum and epidermal growth factor in inducing branching morphogenesis of mouse salivary epithelium

1991 • 136 citations

Growth of epithelial cells in the thymic medulla is under the control of mature T cells.

1992 • 128 citations

Alteration of early vascular development after ablation of cranial neural crest

1989 • 117 citations

Induction of supernumerary tracheal buds and the stimulation of DNA synthesis in the embryonic chick lung and trachea by epidermal growth factor

1980 • 111 citations

Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level.

1991 • 109 citations

Epidermal growth factor inhibits morphogenesis and cell differentiation in cultured mouse embryonic teeth

1985 • 105 citations

Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.

1994 • 96 citations

Branching morphogenesis of mouse salivary epithelium in basement membrane-like substratum separated from mesenchyme by the membrane filter

1991 • 87 citations

Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes

1994 • 79 citations

Epidermal growth factor and transforming growth factor-alpha in the development of epithelial-mesenchymal organs of the mouse.

1990 • 77 citations

Tumor necrosis factor alpha is involved in mouse growth and lymphoid tissue development.

1992 • 64 citations

2 Epidermal Growth Factor and Transforming Growth Factor-α in the Development of Epithelial—Mesenchymal Organs of the Mouse

1990 • 59 citations

Organotypic arrangement of mouse embryonic lung cells on a basement membrane extract: involvement of laminin

1990 • 55 citations

Expression of epidermal and nerve growth factor receptors in human thymus and thymomas

1993 • 43 citations

Impaired development of the thymic primordium after neural crest ablation

1990 • 31 citations