An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Notch Signaling

1995 • 1,282 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Expression of a Delta homologue in prospective neurons in the chick

1995 • 1,019 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

The choice of cell fate in the epidermis of Drosophila

1991 • 736 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

1995 • 669 citations

Jagged: A mammalian ligand that activates notch1

1995 • 617 citations

Positive Selection of Thymocytes

1995 • 604 citations

Selective Events in T Cell Development

1994 • 486 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

1995 • 458 citations

Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells

1992 • 452 citations

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor

1993 • 424 citations

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

1993 • 421 citations

Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch

1995 • 409 citations

Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing

1995 • 392 citations

lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans

1994 • 385 citations

Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos

1993 • 366 citations

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.

1992 • 354 citations

Notch2: a second mammalian Notch gene

1992 • 346 citations

A homolog of Drosophila Notch expressed during mammalian development

1991 • 338 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

1994 • 318 citations

Xotch , the Xenopus Homolog of Drosophila Notch

1990 • 303 citations

Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision

1994 • 254 citations

Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development

1992 • 253 citations

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells

1992 • 246 citations

Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase.

1990 • 235 citations

Different Levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates

1995 • 200 citations

Thymic tumorigenesis induced by overexpression of p56lck.

1991 • 172 citations

The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.

1995 • 165 citations

Modulated expression of notch1 during thymocyte development

1996 • 147 citations

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

1996 • 141 citations

Motch A and Motch B—Two Mouse Notch Homologues Coexpressed in a Wide Variety of Tissues

1993 • 136 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats

1993 • 107 citations

Cloning, Analysis, and Chromosomal Localization of Notch-1, a Mouse Homolog of Drosophila Notch

1993 • 107 citations

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.

1993 • 92 citations

Participation of CD4 coreceptor molecules in T-cell repertoire selection

1991 • 85 citations

Evidence for differential intracellular signaling via CD4 and CD8 molecules.

1994 • 69 citations

Deleted Work

1955 • 0 citations