An Essential Role for the IL-7 Receptor During Intrathymic Expansion of the Positively Selected Neonatal T Cell Repertoire

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells.

1994 • 343 citations

The Earliest T Lineage–Committed Cells Depend on IL-7 for Bcl-2 Expression and Normal Cell Cycle Progression

1997 • 338 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.

1996 • 301 citations

Studies on T cell maturation on defined thymic stromal cell populations in vitro.

1992 • 249 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

1993 • 242 citations

Thymic Stromal Lymphopoietin: A Cytokine That Promotes the Development of IgM+ B Cells In Vitro and Signals Via a Novel Mechanism

1999 • 231 citations

CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection

1993 • 225 citations

Requirement for Stat5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction

1999 • 181 citations

Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction.

1991 • 175 citations

The Common γ-Chain for Multiple Cytokine Receptors

1995 • 168 citations

Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction

1993 • 138 citations

Molecular and Cellular Events in Early Thymocyte Development 11Received for publication October 14, 1997

1998 • 137 citations

In Thymic Selection, Peptide Diversity Gives and Takes Away

1997 • 136 citations

Role of interleukin‐7 in T‐cell development from hematopoietic stem cells

1998 • 130 citations

The role of cytokine receptor signaling in lymphocyte development

1999 • 118 citations

Peripheral T cell survival

1999 • 116 citations

Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor.

1995 • 104 citations

CD69 Expression Discriminates MHC-Dependent and -Independent Stages of Thymocyte Positive Selection

1999 • 83 citations

Positive selection of thymocytes: the long and winding road

1999 • 71 citations

Positive selection of thymocytes involves sustained interactions with the thymic microenvironment.

1995 • 70 citations

Differential Effects of Peptide Diversity and Stromal Cell Type in Positive and Negative Selection in the Thymus

1998 • 64 citations

The majority of postselection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells.

1995 • 55 citations

Distinct roles of the interleukin-7 receptor α chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor α-deficient mice

1998 • 50 citations

Identification of a Developmentally Regulated Phase of Postselection Expansion Driven by Thymic Epithelium

1998 • 46 citations

Intrathymic proliferation of perinatal mouse αβ and §γ T cell receptor-expressing mature T cells

1990 • 42 citations

The Final Maturation of at Least Some Single-Positive Cd4hiThymocytes Does Not Require T Cell Receptor–Major Histocompatibility Complex Contact

1999 • 11 citations