Notch signaling in T cell development

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Jagged: A mammalian ligand that activates notch1

1995 • 617 citations

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1997 • 615 citations

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

1998 • 587 citations

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1996 • 497 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1996 • 481 citations

Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2

1996 • 459 citations

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

1995 • 458 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

1998 • 409 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo

1997 • 380 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Notch2: a second mammalian Notch gene

1992 • 346 citations

A homolog of Drosophila Notch expressed during mammalian development

1991 • 338 citations

Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats

1995 • 324 citations

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

1994 • 318 citations

THE LIN-12/Notch SIGNALING PATHWAY AND ITS REGULATION

1997 • 292 citations

The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1

1998 • 282 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

Jagged2: A Serrate-like Gene Expressed during Rat Embryogenesis

1996 • 243 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

The bHLH gene Hes1 is essential for expansion of early T cell precursors

1999 • 208 citations

Pleiotropic changes controlled by the pre-T-cell receptor

1999 • 199 citations

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)

1997 • 194 citations

Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos

1998 • 193 citations

Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor

1997 • 192 citations

T-cell selection

1998 • 168 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

Modulated expression of notch1 during thymocyte development

1996 • 147 citations

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.

1996 • 141 citations

Motch A and Motch B—Two Mouse Notch Homologues Coexpressed in a Wide Variety of Tissues

1993 • 136 citations

Cloning, Analysis, and Chromosomal Localization of Notch-1, a Mouse Homolog of Drosophila Notch

1993 • 107 citations

REGULATION OF T CELL FATE BY NOTCH

1999 • 105 citations

Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila Notch

1994 • 100 citations

Roles for Proteolysis and Trafficking in Notch Maturation and Signal Transduction

1998 • 92 citations

The Notch Pathway Intermediate HES-1 Silences CD4 Gene Expression

1998 • 83 citations