Molecular Structure and Function of the Glycine Receptor Chloride Channel

The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses

2001 • 3,785 citations

Glutamate receptor ion channels

2005 • 3,667 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

Protein modules and signalling networks

1995 • 2,447 citations

Molecular and cellular mechanisms of general anaesthesia

1994 • 1,779 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Structure and gating mechanism of the acetylcholine receptor pore

2003 • 1,261 citations

Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

1997 • 1,223 citations

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

1987 • 1,166 citations

Release of endogenous Zn2+ from brain tissue during activity

1984 • 1,125 citations

Functional architecture of the mammalian retina

1991 • 1,082 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

Acetylcholine receptor channel imaged in the open state

1995 • 1,002 citations

Emerging structure of the Nicotinic Acetylcholine receptors

2002 • 896 citations

Binding, gating, affinity and efficacy: The interpretation of structure‐activity relationships for agonists and of the effects of mutating receptors

1998 • 880 citations

Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system

1990 • 872 citations

Regulation and Modulation of pH in the Brain

2003 • 831 citations

Stimulation-induced uptake and release of zinc in hippocampal slices

1984 • 812 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Nicotinic Receptors at the Amino Acid Level

2000 • 795 citations

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1987 • 730 citations

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

1994 • 716 citations

Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa

2001 • 695 citations

Zinc coordination sphere in biochemical zinc sites.

2001 • 691 citations

Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants

1992 • 668 citations

Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits

2002 • 654 citations

The pharmacology and mechanism of action of riluzole

1996 • 642 citations

[8] Substituted-cysteine accessibility method

1998 • 578 citations

A glia-derived acetylcholine-binding protein that modulates synaptic transmission

2001 • 564 citations

GABA receptor mechanisms in the central nervous system

1991 • 555 citations

A point mutation in a Drosophila GABA receptor confers insecticide resistance

1993 • 552 citations

Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain.

1991 • 548 citations

From ab initio quantum mechanics to molecular neurobiology: A cation–π binding site in the nicotinic receptor

1998 • 544 citations

Mutations in the α1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia

1993 • 540 citations

Neurosteroid metabolism in the human brain

2001 • 525 citations

The glycinergic inhibitory synapse

2001 • 519 citations

A pharmacological study of the depression of spinal neurones by glycine and related amino acids

1968 • 505 citations

Nicotinic acetylcholine receptor at 4.6 Å resolution: transverse tunnels in the channel 1 1Edited by J. Karn

1999 • 487 citations

The hyperpolarization of spinal motoneurones by glycine and related amino acids

1968 • 481 citations

The impact of receptor desensitization on fast synaptic transmission

1996 • 478 citations

The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses

2000 • 477 citations

Structural Aspects of Metal Liganding to Functional Groups in Proteins

1991 • 454 citations

Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc

1994 • 445 citations

Allosteric Receptors after 30 Years

1998 • 430 citations

Cation–π interactions in ligand recognition and catalysis

2002 • 422 citations

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

1992 • 420 citations

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the α subunit

1994 • 418 citations

GABAA receptor needs two homologous domains of the & beta;-subunit for activation by GABA but not by pentobarbital

1993 • 417 citations

Inhibitory of glycine on spinal neurons in the cat.

1968 • 411 citations

Identification of a gephyrin binding motif on the glycine receptor β subunit

1995 • 410 citations

Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.

1988 • 388 citations

Strychnine Binding Associated with Glycine Receptors of the Central Nervous System

1973 • 388 citations

Glycine receptor heterogeneity in rat spinal cord during postnatal development.

1988 • 383 citations

Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord

1996 • 383 citations

General anaesthetic actions on ligand-gated ion channels

1999 • 381 citations

Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor

1988 • 379 citations

Purification by affinity chromatography of the glycine receptor of rat spinal cord.

1982 • 370 citations

Effects of Gaseous Anesthetics Nitrous Oxide and Xenon on Ligand-gated Ion Channels

2000 • 359 citations

Distribution of glycine receptors at central synapses: an immunoelectron microscopy study.

1985 • 358 citations

Neurosteroids: Beginning of the story

2001 • 342 citations

L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent

2003 • 332 citations

Functional correlation of fetal and adult forms of glycine receptors with developmental changes in inhibitory synaptic receptor channels

1992 • 329 citations

Mapping the conformational wave of acetylcholine receptor channel gating

2000 • 329 citations

Functional Modulation of GABA _A Receptors by cAMP-Dependent Protein Phosphorylation

1992 • 322 citations

Nonsynaptic Glycine Receptor Activation during Early Neocortical Development

1998 • 316 citations

Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel

1986 • 315 citations

Glycine and glycine receptor immunoreactivity in brain and spinal cord

1988 • 312 citations

Coupling of agonist binding to channel gating in the GABAA receptor

2003 • 310 citations

Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor

1998 • 308 citations

Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein

1992 • 307 citations

The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.

1992 • 305 citations

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1995 • 304 citations

Presynaptic glycine receptors enhance transmitter release at a mammalian central synapse

2001 • 304 citations

3 Regulation of ligand-gated ion channels by protein phosphorylation

1999 • 297 citations

Glycine receptor: light microscopic autoradiographic localization with [3H]strychnine

1981 • 296 citations

Deletion of the Mouse Glycine Transporter 2 Results in a Hyperekplexia Phenotype and Postnatal Lethality

2003 • 292 citations

The glycine receptor

1997 • 289 citations

The distribution of glycine in cat spinal cord and roots

1965 • 282 citations

An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor

1990 • 275 citations

The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton

1995 • 273 citations

A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

2003 • 273 citations

Preservation and Staining of Myelinated Nerve Fibers

1998 • 271 citations

Development of Glycinergic Synaptic Transmission to Rat Brain Stem Motoneurons

1998 • 267 citations

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

2000 • 266 citations

Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model

2000 • 263 citations

Cotransmission of GABA and Glycine to Brain Stem Motoneurons

1999 • 252 citations

Glycine and GABA receptors in the mammalian retina

1998 • 251 citations

A Developmental Shift from GABAergic to Glycinergic Transmission in the Central Auditory System

1998 • 249 citations

Anesthetics and Ion Channels: Molecular Models and Sites of Action

2001 • 248 citations

Activation of the Nicotinic Acetylcholine Receptor Involves a Switch in Conformation of the α Subunits

2002 • 243 citations

Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers.

1993 • 239 citations

Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor

1990 • 237 citations

Novel brain function: biosynthesis and actions of neurosteroids in neurons

2000 • 233 citations

gamma-Aminobutyric acid-containing terminals can be apposed to glycine receptors at central synapses

1987 • 224 citations

Genetic manipulation of ion channels: A new approach to structure and mechanism

1989 • 223 citations

Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?

2002 • 223 citations

Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel

1997 • 221 citations

Mutations of γ-aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?

1998 • 216 citations

Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone.

1990 • 210 citations

Glycine receptor β–subunit gene mutation in spastic mouse associated with LINE–1 element insertion

1994 • 208 citations

Identification of glycinergic synapses in the cochlear nucleus through immunocytochemical localization of the postsynaptic receptor

1986 • 207 citations

Glycinergic synapses in the rod pathway of the rat retina: cone bipolar cells express the alpha 1 subunit of the glycine receptor

1994 • 206 citations

Enhancement of homomeric glycine receptor function by longchain alcohols and anaesthetics

1996 • 201 citations

β‐Alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro

2002 • 200 citations

Identifying the Lipid-Protein Interface of the Torpedo Nicotinic Acetylcholine Receptor: Secondary Structure Implications

1994 • 200 citations

Glycine and gamma-aminobutyric acid(A) receptor function is enhanced by inhaled drugs of abuse.

2000 • 200 citations

Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel

2001 • 199 citations

The Location of the Gate in the Acetylcholine Receptor Channel

1998 • 196 citations

A Perspective on the Control of Mammalian Fertilization by Egg-Activated Ion Channels in Sperm: A Tale of Two Channels1

1998 • 195 citations

Distribution of glycine-immunoreactive cell bodies and fibers in the rat brain

1996 • 195 citations

On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat.

1992 • 193 citations

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.

1996 • 193 citations

Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons

1988 • 192 citations

Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors

2000 • 192 citations

A missense mutation in the gene encoding the α1 subunit of the inhibitory glycine receptor in the spasmodic mouse

1994 • 191 citations

Colocalization of gephyrin and GABA_A‐receptor subunits in the rat retina

1995 • 190 citations

Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor.

1990 • 189 citations

Is Glycine a Neurotransmitter ?: Inhibition of Motoneurones by Iontophoresis of Glycine

1967 • 189 citations

Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB)

2002 • 189 citations

EXP-1 is an excitatory GABA-gated cation channel

2003 • 186 citations

IPSC Kinetics at Identified GABAergic and Mixed GABAergic and Glycinergic Synapses onto Cerebellar Golgi Cells

2001 • 185 citations

The spastic mouse: Aberrant splicing of glycine receptor β subunit mRNA caused by intronic insertion of Ll element

1994 • 185 citations

Assembly of the inhibitory glycine receptor: Identification of amino acid sequence motifs governing subunit stoichiometry

1993 • 183 citations

A single amino acid exchange alters the pharmacology of neonatal rat glycine receptor subunit

1990 • 183 citations

Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.

1995 • 180 citations

Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the .alpha.-Subunit

1995 • 179 citations

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin

2000 • 175 citations

The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating.

1995 • 174 citations

Acute effects of ethanol on GABAA and glycine receptor function

1999 • 171 citations

Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia.

1994 • 168 citations

Receptors, gephyrin and gephyrin‐associated proteins: novel insights into the assembly of inhibitory postsynaptic membrane specializations

2000 • 166 citations

Characterisation of inhibitory and excitatory postsynaptic currents of the rat medial superior olive

2000 • 165 citations

Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane.

1993 • 164 citations

Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor

1999 • 161 citations

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms.

1994 • 160 citations

Localization of glycine receptors in the rat central nervous system: An immunocytochemical analysis using monoclonal antibody

1988 • 157 citations

Synaptic Inputs to Stellate Cells in the Ventral Cochlear Nucleus

1998 • 157 citations

Pharmacological Characterization of Glycine-Gated Chloride Currents Recorded in Rat Hippocampal Slices

2002 • 155 citations

A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors.

1996 • 153 citations

Mutation of an arginine residue in the human glycine receptor transforms β-alanine and taurine from agonists into competitive antagonists

1995 • 151 citations

GABA Generates Excitement

2003 • 150 citations

Protein design: novel metal-binding sites

1995 • 149 citations

A Novel Class of Ligand-gated Ion Channel Is Activated by Zn2+

2003 • 149 citations

Mutations in Different Functional Domains of the Human Muscle Acetylcholine Receptor Subunit in Patients with the Slow-Channel congenital Myasthenic Syndrome

1997 • 148 citations

Mutation of Glycine Receptor Subunit Creates β-Alanine Receptor Responsive to GABA

1993 • 147 citations

Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.

1994 • 145 citations

Inhibitory neurotransmission in rat spinal cord: co-localization of glycine- and GABAA-receptors at GABAergic synaptic contacts demonstrated by triple immunofluorescence staining

1994 • 143 citations

Two cDNAs coding for histamine-gated ion channels in D. melanogaster

2001 • 143 citations

Alternative splicing generates two isoforms of the α2 subunit of the inhibitory glycine receptor

1991 • 143 citations

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants

1995 • 143 citations

Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin.

1995 • 142 citations

The Permeation Pathway of Neurotransmitter-Gated Ion Channels

1992 • 142 citations

Enhancement of Glycine Receptor Function by Ethanol Is Inversely Correlated with Molecular Volume at Position α267

1998 • 141 citations

Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the α₁ subunit of the inhibitory glycine receptor

1994 • 141 citations

General anaesthetic action at transmitter-gated inhibitory amino acid receptors

1999 • 137 citations

Pregnenolone sulfate block of GABA_A receptors: mechanism and involvement of a residue in the M2 region of the α subunit

2001 • 137 citations

Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method

2001 • 137 citations

Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant.

1994 • 136 citations

The Glycine Synaptic Receptor: Evidence That Strychnine Binding Is Associated with the Ionic Conductance Mechanism

1974 • 136 citations

Interaction of Benzodiazepines with Central Nervous Glycine Receptors: Possible Mechanism of Action

1974 • 136 citations

Kupffer cells contain a glycine-gated chloride channel

1997 • 135 citations

1 Modulation of ion channels by protein phosphorylation

1999 • 135 citations

Backbone Mutations in Transmembrane Domains of a Ligand-Gated Ion Channel

1999 • 134 citations

The distribution of glycine receptors in the human brain. A light microscopic autoradiographic study using [3H]strychnine

1986 • 134 citations

The interaction of general anaesthetics with recombinant GABA_A and glycine receptors expressed in Xenopus laevis oocytes: a comparative study

1997 • 132 citations

Distinct agonist- and antagonist-binding sites on the glycine receptor

1992 • 132 citations

Immunocytochemical localization of glycine receptors in the mammalian retina

1993 • 132 citations

Alternative splicing generates two variants of the alpha 1 subunit of the inhibitory glycine receptor

1991 • 130 citations

GABA and glycine co‐release optimizes functional inhibition in rat brainstem motoneurons in vitro

2002 • 130 citations

Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes

1996 • 128 citations

Conversion of the Ion Selectivity of the 5-HT3AReceptor from Cationic to Anionic Reveals a Conserved Feature of the Ligand-gated Ion Channel Superfamily

2001 • 127 citations

Molecular determinants of glycine receptor subunit assembly

1999 • 127 citations

Anion permeation in GABA- and glycine-gated channels of mammalian cultured hippocampal neurons

1993 • 127 citations

Mutational analysis of familial and sporadic hyperekplexia

1995 • 126 citations

Isoform-selective deficit of glycine receptors in the mouse mutant spastic

1992 • 125 citations

Inhibition of Spinal Neurones by Glycine

1967 • 122 citations

Mutations Affecting the Glycine Receptor Agonist Transduction Mechanism Convert the Competitive Antagonist, Picrotoxin, into an Allosteric Potentiator

1995 • 122 citations

Isoform Heterogeneity of the Human Gephyrin Gene (GPHN), Binding Domains to the Glycine Receptor, and Mutation Analysis in Hyperekplexia

2003 • 122 citations

The Extracellular Linker of Muscle Acetylcholine Receptor Channels Is a Gating Control Element

2000 • 121 citations

Glycine‐gated chloride channels in neutrophils attenuate calcium influx and superoxide production

2000 • 121 citations

M2 Pore Mutations Convert the Glycine Receptor Channel from Being Anion- to Cation-Selective

2000 • 120 citations

Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor.

1994 • 120 citations

Selective clustering of GABA(A) and glycine receptors in the mammalian retina

1996 • 119 citations

Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating

1999 • 118 citations

Diversity of glycine receptors in the mouse retina: Localization of the α4 subunit

2006 • 118 citations

Hyperekplexia: a treatable neurogenetic disease

2002 • 117 citations

A frameshift mutation in the mouse α₁ glycine receptor gene (Gira1) results in progressive neurological symptoms and juvenile death

1994 • 117 citations

Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes

2002 • 115 citations

Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site.

1992 • 111 citations

Terpene Trilactones from Ginkgo biloba Are Antagonists of Cortical Glycine and GABAA Receptors

2003 • 110 citations

Development of adult-type inhibitory glycine receptors in the central auditory system of rats

1997 • 109 citations

Kinetic and mutational analysis of Zn²⁺ modulation of recombinant human inhibitory glycine receptors

2000 • 108 citations

State-dependent Accessibility and Electrostatic Potential in the Channel of the Acetylcholine Receptor

1998 • 108 citations

Binding sites for exogenous and endogenous non-competitive inhibitors of the nicotinic acetylcholine receptor

1998 • 107 citations

Localization of glycine receptor α1 subunit mRNA-containing neurons in the rat brain: An analysis using in situ hybridization histochemistry

1991 • 107 citations

NovelGLRA1Missense Mutation (P250T) in Dominant Hyperekplexia Defines an Intracellular Determinant of Glycine Receptor Channel Gating

1999 • 107 citations

Modulation of inhibitory glycine receptors by phosphorylation by protein kinase C and cAMP-dependent protein kinase.

1994 • 106 citations

Amino Acid Neurotransmitter Receptor/Chloride Channels of Mammalian Sperm and the Acrosome Reaction1

1997 • 106 citations

Regional distribution of cells expressing glycine receptor α2 subunit mRNA in the rat brain

1992 • 104 citations

Neurosteroids and behavior

2001 • 104 citations

The Human Glycine Receptor Subunit α3

1998 • 104 citations

Picrotoxin Blockade of Invertebrate Glutamate‐Gated Chloride Channels: Subunit Dependence and Evidence for Binding Within the Pore

1999 • 103 citations

Properties of human glycine receptors containing the hyperekplexia mutation α1(K276E), expressed in Xenopus oocytes

1998 • 102 citations

The Role of an α Subtype M₂-M₃His in Regulating Inhibition of GABA_AReceptor Current by Zinc and Other Divalent Cations

1998 • 101 citations

Inhibition of rho1 receptor GABAergic currents by alcohols and volatile anesthetics.

1996 • 101 citations

Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.

2000 • 100 citations

GABAergic and glycinergic IPSCs in Ganglion Cells of Rat Retinal Slices

1997 • 99 citations

Point mutation of glycine receptor α1 subunit in the spasmodic mouse affects agonist responses

1994 • 98 citations

Structural Determinants of Fast Desensitization and Desensitization–Deactivation Coupling in GABA_AReceptors

2001 • 97 citations

Identification of an inhibitory Zn²⁺ binding site on the human glycine receptor α1 subunit

1999 • 97 citations

How The Brain Works

1975 • 97 citations

The transmembrane domains of the nicotinic acetylcholine receptor contain alpha-helical and beta structures.

1994 • 96 citations

A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.

1996 • 96 citations

Cation-selective Mutations in the M2 Domain of the Inhibitory Glycine Receptor Channel Reveal Determinants of Ion-Charge Selectivity

2002 • 96 citations

γ-Aminobutyric Acid Increases the Water Accessibility of M3 Membrane-Spanning Segment Residues in γ-Aminobutyric Acid Type A Receptors

1999 • 94 citations

GABAA Receptor M2–M3 Loop Secondary Structure and Changes in Accessibility during Channel Gating

2002 • 93 citations

Cyanotriphenylborate: subtype-specific blocker of glycine receptor chloride channels.

1994 • 93 citations

A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition.

1995 • 92 citations

The Role of Tryptophan Residues in the 5-Hydroxytryptamine3 Receptor Ligand Binding Domain

2000 • 91 citations

Modulation of glycine-activated ion channel function by G-protein βγ subunits

2003 • 90 citations

GABA mediates presynaptic inhibition at glycinergic synapses in a rat auditory brainstem nucleus

2000 • 90 citations

Ubiquitination Precedes Internalization and Proteolytic Cleavage of Plasma Membrane-bound Glycine Receptors

2001 • 89 citations

Diversity of glycine receptors in the mouse retina: Localization of the α3 subunit

2003 • 88 citations

Cloning of a glycine receptor subtype expressed in rat brain and spinal cord during a specific period of neuronal development

1991 • 87 citations

The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.

1995 • 87 citations

Presynaptic inhibition by serotonin of glycinergic inhibitory synaptic currents in the rat brain stem

1995 • 86 citations

Structure of the Transition State of Gating in the Acetylcholine Receptor Channel Pore: A Φ-Value Analysis

2002 • 86 citations

Neurotransmitters in the retina

1996 • 85 citations

Analysis of Excitatory and Inhibitory Spontaneous Synaptic Activity in Mouse Retinal Ganglion Cells

1998 • 84 citations

A GLRA1 null mutation in recessive hyperekplexia challenges the functional role of glycine receptors.

1996 • 83 citations

Structural and Electrostatic Properties of the 5-HT3Receptor Pore Revealed by Substituted Cysteine Accessibility Mutagenesis

2001 • 83 citations

Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds.

1995 • 83 citations

Hydrophobic Interactions Mediate Binding of the Glycine Receptor β‐Subunit to Gephyrin

1999 • 81 citations

Solubilization of the glycine receptor from rat spinal cord

1981 • 81 citations

Glycine receptors containing the α4 subunit in the embryonic sympathetic nervous system, spinal cord and male genital ridge

2000 • 80 citations

Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin

2000 • 80 citations

Chloride Channels of Glycine and GABA Receptors with Blockers: Monte Carlo Minimization and Structure-Activity Relationships

2000 • 80 citations

A Reluctant Gating Mode of Glycine Receptor Channels Determines the Time Course of Inhibitory Miniature Synaptic Events in Zebrafish Hindbrain Neurons

1998 • 80 citations

The human glycine receptor β subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes

1996 • 80 citations

The glycine receptor: pharmacological studies and mathematical modeling of the allosteric interaction between the glycine- and strychnine-binding sites.

1986 • 80 citations

The interaction of general anaesthetics and neurosteroids with GABAA and glycine receptors

1999 • 79 citations

Kinetic properties of the glycine receptor main‐ and sub‐conductance states of mouse spinal cord neurones in culture.

1991 • 79 citations

Role of Charged Residues in Coupling Ligand Binding and Channel Activation in the Extracellular Domain of the Glycine Receptor

2003 • 79 citations

Glycinergic synaptic currents in Golgi cells of the rat cerebellum.

1995 • 79 citations

Distribution patterns of mRNAs encoding glycine receptor channels in the developing rat spinal cord

1995 • 77 citations

Evidence for a Centrally Located Gate in the Pore of a Serotonin-Gated Ion Channel

2002 • 77 citations

Differential expression of glycine receptor subunits in the retina of the rat: A study using immunohistochemistry andin situhybridization

1994 • 77 citations

A single β subunit M2 domain residue controls the picrotoxin sensitivity of αβ heteromeric glycine receptor chloride channels

2001 • 76 citations

Compound heterozygosity and nonsense mutations in the α1-subunit of the inhibitory glycine receptor in hyperekplexia

2001 • 76 citations

Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area.

2001 • 76 citations

Transgenic Expression of a Mutant Glycine Receptor Decreases Alcohol Sensitivity of Mice

2002 • 76 citations

Activation of human α1 and α2 homomeric glycine receptors by taurine and GABA

2001 • 75 citations

Diversity of glycine receptors in the mouse retina: Localization of the α2 subunit

2004 • 75 citations

Potentiation of the glycine-activated Cl- current by ethanol in cultured mouse spinal neurons.

1996 • 75 citations

Analysis of GLRA1 in hereditary and sporadic hyperekplexia: a novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis.

1996 • 75 citations

Effect of ivermectin on γ-aminobutyric acid-induced chloride currents in mouse hippocampal embryonic neurones

1994 • 74 citations

Glycine and GABA_A receptor subunits on Renshaw cells: Relationship with presynaptic neurotransmitters and postsynaptic gephyrin clusters

2002 • 74 citations

Regional distribution of the cells expressing glycine receptor β subunit mRNA in the rat brain

1991 • 74 citations

Kinetic properties of the α₂ homo‐oligomeric glycine receptor impairs a proper synaptic functioning

2003 • 72 citations

Topography of Nicotinic Acetylcholine Receptor Membrane-embedded Domains

2000 • 72 citations

Expression of the human glycine receptor alpha 1 subunit in Xenopus oocytes: apparent affinities of agonists increase at high receptor density.

1994 • 71 citations

Zinc Potentiation of the Glycine Receptor Chloride Channel Is Mediated by Allosteric Pathways

1998 • 71 citations

Fast Potentiation of Glycine Receptor Channels by Intracellular Calcium in Neurons and Transfected Cells

2000 • 71 citations

Glycine receptors in the rod pathway of the macaque monkey retina

1996 • 70 citations

The Surface Accessibility of the Glycine Receptor M2–M3 Loop Is Increased in the Channel Open State

2001 • 68 citations

The α-Helix and the Organization and Gating of Channels

2002 • 67 citations

The depression of spinal inhibition by morphine

1969 • 66 citations

Localization of rat glycine receptor ?1 and ?2 subunit transcripts in the developing auditory brainstem

2001 • 66 citations

Inhibition of spinal or hypoglossal motoneurons of the newborn rat by glycine or GABA

2002 • 65 citations

Openings of the Rat Recombinant α1 Homomeric Glycine Receptor as a Function of the Number of Agonist Molecules Bound

2002 • 65 citations

Molecular mechanisms of inherited startle syndromes

1995 • 65 citations

A Role for the Human Sperm Glycine Receptor/Cl− Channel in the Acrosome Reaction Initiated by Recombinant ZP31

2002 • 64 citations

Distribution of glycine receptor immunoreactivity in the spinal cord of the rat: Cytochemical evidence for a differential glycinergic control of lamina I and V nociceptive neurons

1988 • 64 citations

Phosphorylation of the 48-kDa subunit of the glycine receptor by protein kinase C.

1991 • 63 citations

Deficit of Spinal Cord Glycine/Strychnine Receptors in Inherited Myoclonus of Poll Hereford Calves

1988 • 63 citations

Identification of Acetylcholine Receptor Channel-Lining Residues in the M1 Segment of the β-Subunit

1997 • 63 citations

Amino Acid Volume and Hydropathy of a Transmembrane Site Determine Glycine and Anesthetic Sensitivity of Glycine Receptors

1999 • 63 citations

Hyperekplexia phenotype due to compound heterozygosity for GLRA1 gene mutations

1999 • 63 citations

Startle disorders of man: Hyperekplexia, jumping and startle epilepsy

1988 • 62 citations

Identification of Transduction Elements for Benzodiazepine Modulation of the GABA_AReceptor: Three Residues Are Required for Allosteric Coupling

1999 • 62 citations

Zinc co‐localizes with GABA and glycine in synapses in the lamprey spinal cord

2001 • 62 citations

Activation of presynaptic glycine receptors facilitates glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus neurons

2003 • 61 citations

Asymmetric Cross-inhibition between GABAA and Glycine Receptors in Rat Spinal Dorsal Horn Neurons

2003 • 61 citations

Neurosteroids act on the GABAA receptor at sites on the N-terminal side of the middle of TM2

1998 • 60 citations

Tryptophan scanning mutagenesis in TM4 of the GABAA receptor α1 subunit: implications for modulation by inhaled anesthetics and ion channel structure

2002 • 60 citations

Probing the Structure of the Nicotinic Acetylcholine Receptor Ion Channel with the Uncharged Photoactivable Compound [3H]Diazofluorene

1998 • 60 citations

Glycine Receptor Knock-In Mice and Hyperekplexia-Like Phenotypes: Comparisons with the Null Mutant

2003 • 59 citations

Disorders of the inhibitory glycine receptor: the spastic mouse

1990 • 59 citations

Comparison of glycine and GABA actions on the zebrafish homomeric glycine receptor

1999 • 58 citations

Structural evidence that propofol stabilizes different GABA(A) receptor states at potentiating and activating concentrations.

2002 • 58 citations

Development of Spontaneous Glycinergic Currents in the Mauthner Neuron of the Zebrafish Embryo

2000 • 58 citations

Insights into the Structural Basis for Zinc Inhibition of the Glycine Receptor

2003 • 58 citations

Localization of the strychnine binding site on the 48-kilodalton subunit of the glycine receptor

1990 • 57 citations

Structure and dynamics of the pore-lining helix of the nicotinic receptor: MD simulations in water, lipid bilayers, and transbilayer bundles

2000 • 55 citations

Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice

2003 • 55 citations

Changes in the properties of developing glycine receptors in cultured mouse spinal neurons

1998 • 54 citations

The Intrinsic Electrostatic Potential and the Intermediate Ring of Charge in the Acetylcholine Receptor Channel

2000 • 53 citations

Desensitization of Homomeric α1 Glycine Receptor Increases with Receptor Density

2002 • 53 citations

Genetic and radiation hybrid mapping of the hyperekplexia region on chromosome 5q.

1992 • 53 citations

Mutations at the GABA receptor selectivity filter: a possible role for effective charges

2003 • 53 citations

Potentiation of inhibitory glycinergic neurotransmission by Zn²⁺: a synergistic interplay between presynaptic P2X₂ and postsynaptic glycine receptors

2002 • 52 citations

Pharmacological Evidence for Two Types of Postsynaptic Glycinergic Receptors on the Mauthner Cell of 52-h-Old Zebrafish Larvae

1997 • 52 citations

Functional glycine receptors are expressed by postnatal nestin‐positive neural stem/progenitor cells

2002 • 52 citations

A Novel Domain of the Inhibitory Glycine Receptor Determining Antagonist Efficacies: Further Evidence for Partial Agonism Resulting from Self-Inhibition

1999 • 51 citations

Modulation of glycine receptors in retinal ganglion cells by zinc

1999 • 51 citations

High-Affinity Zinc Potentiation of Inhibitory Postsynaptic Glycinergic Currents in the Zebrafish Hindbrain

2001 • 51 citations

Interplexiform cells of the goldfish retina

1990 • 50 citations

The Startle Disease Mutation Q266H, in the Second Transmembrane Domain of the Human Glycine Receptor, Impairs Channel Gating

1999 • 50 citations

Effects of ginsenosides on GABAA receptor channels expressed in xenopus oocytes

2003 • 50 citations

Structural Evidence that Propofol Stabilizes Different GABA_AReceptor States at Potentiating and Activating Concentrations

2002 • 50 citations

BN52021, a platelet activating factor antagonist, is a selective blocker of glycine-gated chloride channel

2002 • 50 citations

A Highly Conserved Aspartic Acid Residue in the Signature Disulfide Loop of the α1 Subunit Is a Determinant of Gating in the Glycine Receptor

2003 • 50 citations

Steroid modulation of the strychnine-sensitive glycine receptor

1992 • 49 citations

Distribution of GABA and glycine receptors on bipolar and ganglion cells in the mammalian retina

2000 • 49 citations

Subunit-Selective Contribution to Channel Gating of the M4 Domain of the Nicotinic Receptor

2002 • 49 citations

Modulation of Synaptic Transmission by Nociceptin/Orphanin FQ and Nocistatin in the Spinal Cord Dorsal Horn of Mutant Mice Lacking the Nociceptin/Orphanin FQ Receptor

2001 • 49 citations

Functional glycine receptor maturation in the absence of glycinergic input in dopaminergic neurones of the rat substantia nigra

2002 • 48 citations

Coupled Proteolytic and Mass Spectrometry Studies Indicate a Novel Topology for the Glycine Receptor

2000 • 47 citations

The binding of strychnine and strychnine analogs to synaptic membranes of rat brainstem and spinal cord.

1977 • 47 citations

Post-synaptic inhibitory mechanisms of anaesthesia; glycine receptors

1998 • 47 citations

A Nonsense Mutation in the α1 Subunit of the Inhibitory Glycine Receptor Associated with Bovine Myoclonus

2001 • 46 citations

Kinetic Determinants of Agonist Action at the Recombinant Human Glycine Receptor

2003 • 46 citations

Investigation of the α1-Glycine Receptor Channel-Opening Kinetics in the Submillisecond Time Domain

1999 • 46 citations

Binding site stoichiometry and the effects of phosphorylation on human α1 homomeric glycine receptors

2002 • 46 citations

Low level expression of glycine receptor beta subunit transgene is sufficient for phenotype correction in spastic mice.

1996 • 46 citations

Competitive inhibition of the glycine-induced current by pregnenolone sulfate in cultured chick spinal cord neurons

1997 • 45 citations

A novel recessive hyperekplexia allele GLRA1 (S231R): genotyping by MALDI-TOF mass spectrometry and functional characterisation as a determinant of cellular glycine receptor trafficking

2002 • 45 citations

Opposing Effects of Molecular Volume and Charge at the Hyperekplexia Site α1(P250) Govern Glycine Receptor Activation and Desensitization

2001 • 45 citations

Interaction of the neuroprotective drug riluzole with GABAA and glycine receptor channels

2001 • 45 citations

Structure of Ligand-Gated Ion Channels: Critical Assessment of Biochemical Data Supports Novel Topology

2001 • 44 citations

Single Channel Analysis of Conductance and Rectification in Cation-selective, Mutant Glycine Receptor Channels

2002 • 44 citations

Pore size and negative charge as structural determinants of permeability in the Torpedo nicotinic acetylcholine receptor channel

1992 • 44 citations

Effects of Ethanol on Recombinant Glycine Receptors Expressed in Mammalian Cell Lines

1998 • 44 citations

Probing the Topology of the Glycine Receptor by Chemical Modification Coupled to Mass Spectrometry

2002 • 43 citations

Identification of a Novel Residue within the Second Transmembrane Domain That Confers Use-facilitated Block by Picrotoxin in Glycine α1 Receptors

2002 • 43 citations

Neurosteroid modulation of recombinant and synaptic GABAA receptors

2001 • 43 citations

Antagonism of Inhalant and Volatile Anesthetic Enhancement of Glycine Receptor Function

2001 • 43 citations

A Basic Cluster Determines Topology of the Cytoplasmic M3-M4 Loop of the Glycine Receptor α1 Subunit

2003 • 43 citations

Glycine blocks the increase in intracellular free Ca²⁺due to vasoactive mediators in hepatic parenchymal cells

2002 • 43 citations

Hyperekplexia mutations of the glycine receptor unmask the inhibitory subsite for β-amino-acids

1995 • 42 citations

Evidence for coassembly of mutant GABA_Cρ1 with GABA_Aγ2S, glycine α1 and glycine α2 receptor subunits in vitro

2000 • 42 citations

Anesthetic and ethanol effects on spontaneously opening glycine receptor channels

2002 • 42 citations

Partition of Transient and Sustained Inhibitory Glycinergic Input to Retinal Ganglion Cells

1997 • 42 citations

Molecular Determinants of Proton Modulation of Glycine Receptors

2004 • 42 citations

Disease-specific human glycine receptor alpha1 subunit causes hyperekplexia phenotype and impaired glycine- and GABA(A)-receptor transmission in transgenic mice.

2002 • 42 citations

Direct inhibition of glycine receptors by genistein, a tyrosine kinase inhibitor

2000 • 42 citations

Characterization of the Spontaneous Synaptic Activity of Amacrine Cells in the Mouse Retina

2001 • 42 citations

Three distinct structural environments of a transmembrane domain in the inwardly rectifying potassium channel ROMK1 defined by perturbation.

1995 • 41 citations

Potentiation of chloride responses to glycine by three 5‐HT₃ antagonists in rat spinal neurones

1996 • 41 citations

Multiple picrotoxinin effect on glycine channels in rat hippocampal neurons

1998 • 41 citations

Arg-274 and Leu-277 of the γ-Aminobutyric Acid Type A Receptor α2 Subunit Define Agonist Efficacy and Potency

2000 • 40 citations

Glycine Receptor β Subunits Play a Critical Role in Potentiation of Glycine Responses by ICS-205,930

2000 • 40 citations

Enhancement of glycine receptor function by ethanol: role of phosphorylation

1998 • 40 citations

The Mouse Sperm Glycine Receptor/Chloride Channel: Cellular Localization and Involvement in the Acrosome Reaction Initiated by Glycine

2000 • 39 citations

Mutagenesis of the GABA π1 receptor alters agonist affinity and channel gating

1994 • 38 citations

Glycine Receptors and Glycinergic Synaptic Input at the Axon Terminals of Mammalian Retinal Rod Bipolar Cells

2003 • 38 citations

Ethanol Potentiation of Glycine Receptors Expressed in Xenopus Oocytes Antagonized by Increased Atmospheric Pressure

2003 • 37 citations

Distribution of glycine receptor subunits on primate retinal ganglion cells: a quantitative analysis

2000 • 37 citations

Functional Reconstitution and Characterization of Recombinant Human α1-Glycine Receptors

2001 • 37 citations

Identification of a New Ligand Binding Domain in the α1 Subunit of the Inhibitory Glycine Receptor

1999 • 37 citations

Selective Blocking Effects of Tropisetron and Atropine on Recombinant Glycine Receptors

1999 • 37 citations

Glycine current in rat septal cholinergic neuron in culture: monophasic positive modulation by Zn2+

1996 • 37 citations

Disease-Specific Human Glycine Receptor α₁Subunit Causes Hyperekplexia Phenotype and Impaired Glycine- and GABA_A-Receptor Transmission in Transgenic Mice

2002 • 36 citations

Modulation of the glycine response by Ca²⁺‐permeable AMPA receptors in rat spinal neurones

1999 • 35 citations

The Zona Pellucida-Initiated Acrosome Reaction: Defect Due to Mutations in the Sperm Glycine Receptor/Cl− Channel

2000 • 35 citations

Inhibition of glycine and GABA receptor binding by several opiate agonists and antagonists

1981 • 34 citations

Channel-Lining Residues in the M3 Membrane-Spanning Segment of the Cystic Fibrosis Transmembrane Conductance Regulator

1998 • 34 citations

Allosteric modulators affect the efficacy of partial agonists for recombinant GABA_A receptors

2000 • 33 citations

Ten years of NGDO action against river blindness

2002 • 33 citations

Deficit of inhibitory glycine receptors in spinal cord from Peruvian Pasos: evidence for an equine form of inherited myoclonus

1993 • 33 citations

Expression of glycine receptor subunits and gephyrin in single bipolar cells of the rat retina

1995 • 33 citations

Benzodiazepines Block α₂-Containing Inhibitory Glycine Receptors in Embryonic Mouse Hippocampal Neurons

2003 • 33 citations

Glycine Antagonists Structurally Related to 4,5,6,7‐Tetrahydroisoxazolo[5,4‐c]pyridin‐3‐ol Inhibit Binding of [³H]Strychnine to Rat Brain Membranes

1986 • 32 citations

A residue in the middle of the M2‐M3 loop of the β₄ subunit specifically affects gating of neuronal nicotinic receptors

1998 • 32 citations

Protein kinase Cε is involved in ethanol potentiation of glycine-gated Cl− current in rat neurons of ventral tegmental area

2003 • 32 citations

Colchicine is a competitive antagonist at human recombinant gamma-aminobutyric acidA receptors.

1998 • 32 citations

Functional characterization of compound heterozygosity for GlyRα1 mutations in the startle disease hyperekplexia

2002 • 32 citations

Activation of endogenous protein kinase C enhances currents through α1 and α2 glycine receptor channels

1995 • 32 citations

Bidirectional allosteric modulation of strychnine-sensitive glycine receptors by tropeines and 5-HT3 serotonin receptor ligands

1998 • 31 citations

Asymmetric contribution of α and β subunits to the activation of αβ heteromeric glycine receptors

2003 • 31 citations

Comparative Surface Accessibility of a Pore-lining Threonine Residue (T6′) in the Glycine and GABAA Receptors

2002 • 30 citations

Bovine myoclonus: Model of human hyperekplexia (Startle disease)

2002 • 30 citations

A mutation (V260M) in the middle of the M2 pore-lining domain of the glycine receptor causes hereditary hyperekplexia

2001 • 30 citations

Subunit-Specific Action of an Anticonvulsant Thiobutyrolactone on Recombinant Glycine Receptors Involves a Residue in the M2 Membrane-Spanning Region

2000 • 30 citations

Kinetic analysis of recombinant mammalian ?1 and ?1? glycine receptor channels

2003 • 30 citations

Functional properties of strychnine-sensitive glycine receptors expressed in Xenopus oocytes injected with a single mRNA

1991 • 30 citations

Immunochemical Identification of the Glycine Receptor/Cl−Channel in Porcine Sperm

1996 • 30 citations

A model of the glycine receptor deduced from Brownian dynamics studies

2003 • 27 citations

Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human α₁β glycine receptors

2002 • 26 citations

Activation of glycine and glutamate receptors increases intracellular calcium in cells derived from the endocrine pancreas.

1998 • 26 citations

Mutations in the M1 region of the nicotinic acetylcholine receptor alter the sensitivity to inhibition by quinacrine

1995 • 26 citations

Transient neuromotor phenotype in transgenic spastic mice expressing low levels of glycine receptor β‐subunit: an animal model of startle disease

2000 • 26 citations

Kinetic properties of alpha 1 beta 1 gamma-aminobutyric acidA receptor channels expressed in Chinese hamster ovary cells: regulation by pentobarbital and picrotoxin.

1992 • 26 citations

Strychnine activates neuronal α7 nicotinic receptors after mutations in the leucine ring and transmitter binding site domains

1999 • 26 citations

Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the β‐amino acid agonist, taurine

2001 • 25 citations

Hamster sperm glycine receptor: Evidence for its presence and involvement in the acrosome reaction

2000 • 25 citations

Hyperekplexia (Startle Disease)

2003 • 24 citations

Colchicine competitively antagonizes glycine receptors expressed in Xenopus oocytes

1998 • 24 citations

N‐methyl‐ <scp>d</scp>‐aspartate enhancement of the glycine response in the rat sacral dorsal commissural neurons

2000 • 23 citations

The Human Glycine Receptor β Subunit Gene (GLRB): Structure, Refined Chromosomal Localization, and Population Polymorphism

1998 • 23 citations

Ethanol Inhibition of Glycine-Activated Responses in Neurons of Ventral Tegmental Area of Neonatal Rats

2001 • 23 citations

Glycinergic potentiation by some 5-HT3 receptor antagonists: insight into selectivity

2000 • 22 citations

Tryptophan Substitutions at Lipid-exposed Positions of the Gamma M3 Transmembrane Domain Increase the Macroscopic Ionic Current Response of the Torpedo californica Nicotinic Acetylcholine Receptor

2001 • 22 citations

Evidence for distinct conformations of the two α1 subunits in diazepam-bound GABAA receptors

2001 • 22 citations

Microtubule Depolymerization Inhibits Ethanol‐Induced Enhancement of GABA_A Responses in Stably Transfected Cells

1996 • 21 citations

Synthesis of .beta.-spiro[pyrrolidinoindolines], their binding to the glycine receptor, and in vivo biological activity

1977 • 21 citations

Modulation of glycine responses by dihydropyridines and verapamil in rat spinal neurons

2001 • 21 citations

Point Mutation in the First Transmembrane Region of the β2 Subunit of the γ-Aminobutyric Acid Type A Receptor Alters Desensitization Kinetics of γ-Aminobutyric Acid- and Anesthetic-induced Channel Gating

2002 • 21 citations

Nicotinic Receptor M3 Transmembrane Domain: Position 8′ Contributes to Channel Gating

2002 • 20 citations

Modulation of miniature inhibitory postsynaptic currents by isoflurane in rat dissociated neurons with glycinergic synaptic boutons

2001 • 20 citations

Midget and parasol ganglion cells of the primate retina express the α1 subunit of the glycine receptor

1999 • 19 citations

Protein Kinase C Modulation of Ethanol Inhibition of Glycine-Activated Current in Dissociated Neurons of Rat Ventral Tegmental Area

2002 • 18 citations

Glycine Receptors and Glycinergic Synaptic Transmission in the Deep Cerebellar Nuclei of the Rat: A Patch-Clamp Study

2003 • 17 citations

Increased γ‐Aminobutyric Acid Receptor Function in the Cerebral Cortex of Myoclonic Calves with an Hereditary Deficit in Glycine/Strychnine Receptors

1990 • 17 citations

Dual cooperative allosteric modulation of binding to ionotropic glycine receptors

2002 • 17 citations

Genistein directly blocks glycine receptors of rat neurons freshly isolated from the ventral tegmental area

2003 • 16 citations

Molecular aspects of drug resistance in parasitic helminths

1993 • 16 citations

Spinal inhibitory synaptic transmission in the glycine receptor mouse mutant spastic

2003 • 16 citations

High-affinity strychnine binding to adrenal medulla chromaffin cell membranes

1990 • 15 citations

Preferential release of epinephrine by glycine from adrenal chromaffin cells

1992 • 15 citations

Novel antagonists of the inhibitory glycine receptor derived from quinolinic acid compounds.

1996 • 14 citations

Ethanol affects the function of a neurotransmitter receptor protein without altering the membrane lipid phase

1998 • 14 citations

Gating of α3β4 neuronal nicotinic receptor can be controlled by the loop M2-M3 of both α3 and β4 subunits

1999 • 13 citations

Modulation of glycine-induced currents by zinc and other metal cations in neurons acutely dissociated from the dorsal motor nucleus of the vagus of the rat

1999 • 13 citations

Diagnosis of neuraxial oedema in calves

1986 • 13 citations

Mode of action of ICS 205,930, a novel type of potentiator of responses to glycine in rat spinal neurones

1999 • 12 citations

A novel glycine receptor αZ1 subunit variant in the zebrafish brain

2003 • 12 citations

Effects of ginsenosides on glycine receptor alpha1 channels expressed in Xenopus oocytes.

2003 • 12 citations

Actions of 3‐[2′‐phosphonomethyl[1,1′‐biphenyl]‐3‐yl]alanine (PMBA) on cloned glycine receptors

1999 • 10 citations

Inhibition of α-subunit glycine receptors by quinoxalines

2003 • 10 citations

Ethanol Suppresses Fast Potentiation of Glycine Currents by Glutamate

2002 • 10 citations

Potentiation of glycine responses by dideoxyforskolin and tamoxifen in rat spinal neurons

2003 • 10 citations

Responses of small- and large-field bipolar cells to GABA and glycine

2001 • 9 citations

Glycinergic synaptic transmission to bullfrog retinal bipolar cells is input-specific

2002 • 9 citations

Spastic, an hereditary neurological mutation in the mouse characterized by vertebral arthropathy and leptomeningeal cyst formation.

1970 • 9 citations

Caesium ions: a glycine‐activated channel agonist in rat spinal cord neurones grown in cell culture

1989 • 8 citations

Autoradiographic localization of strychnine-sensitive glycine receptor in bovine adrenal medulla

1993 • 7 citations

Functional α3-glycine receptors in rat adrenal

1995 • 7 citations

Statistical coassembly of glycine receptor α1 wildtype and the hyperekplexia mutant α1(P250T) in HEK 293 cells: impaired channel function is not dominant in the recombinant system

2002 • 5 citations

A recombinant glycine receptor fragment forms homo-oligomers distinct from its GABAA counterpart11Edited by B. Holland

2001 • 5 citations