Direct inhibition of glycine receptors by genistein, a tyrosine kinase inhibitor

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

1987 • 1,166 citations

Regulation of NMDA receptors by tyrosine kinases and phosphatases

1994 • 671 citations

Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain.

1991 • 548 citations

[30] Use and specificity of genistein as inhibitor of protein-tyrosine kinases

1991 • 421 citations

Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+

1990 • 370 citations

The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.

1992 • 305 citations

3 Regulation of ligand-gated ion channels by protein phosphorylation

1999 • 297 citations

Glycine receptors: heterogeneous and widespread in the mammalian brain

1991 • 232 citations

Modulation of GABAA receptors by tyrosine phosphorylation

1995 • 224 citations

Convulsant/depressant site of action at the allosteric benzodiazepine-gaba receptor-ionophore complex

1983 • 164 citations

Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.

1994 • 145 citations

Point mutations in the M2 region of the alpha, beta, or gamma subunit of the GABAA channel that abolish block by picrotoxin.

1995 • 142 citations

Direct action of genistein on CFTR

1997 • 139 citations

Modulation Of Amind Acid-Gated Ion Channels By Protein Phoshorlation

1996 • 130 citations

Genistein activates CFTR Cl- channels via a tyrosine kinase- and protein phosphatase-independent mechanism

1997 • 117 citations

Modulation of glycine receptor chloride channels by cAMP-dependent protein kinase in spinal trigeminal neurons

1990 • 112 citations

Modulation of inhibitory glycine receptors by phosphorylation by protein kinase C and cAMP-dependent protein kinase.

1994 • 106 citations

Inhibition of L-type Calcium Current in Rat Ventricular Cells by the Tyrosine Kinase Inhibitor, Genistein and its Inactive Analog, Daidzein

1996 • 99 citations

Glycine-gated chloride current in acutely isolated rat hypothalamic neurons

1989 • 99 citations

Modulation of GABA_AReceptor Function by Tyrosine Phosphorylation of β Subunits

1997 • 92 citations

Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila gamma-aminobutyric acid receptors.

1995 • 84 citations

Location of a high affinity Zn2+ binding site in the channel of alpha1beta1 gamma-aminobutyric acidA receptors.

1998 • 82 citations

Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by Lavendustin-A and its analogue.

1991 • 81 citations

The interaction of general anaesthetics and neurosteroids with GABAA and glycine receptors

1999 • 79 citations

Direct block of voltage-sensitive sodium channels by genistein, a tyrosine kinase inhibitor.

1997 • 78 citations

Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.

1991 • 70 citations

Phosphorylation of the 48-kDa subunit of the glycine receptor by protein kinase C.

1991 • 63 citations

Maintenance of recombinant type A gamma-aminobutyric acid receptor function: role of protein tyrosine phosphorylation and calcineurin.

1998 • 61 citations

Cell–cell coupling occurs in dorsal medullary neurons after minimizing anatomical-coupling artifacts

1997 • 60 citations

The tyrosine kinase inhibitor genistein directly inhibits GABAA receptors

1999 • 59 citations

Changes in the properties of developing glycine receptors in cultured mouse spinal neurons

1998 • 54 citations

Inhibitory effects of genistein on ATP‐sensitive K⁺ channels in rabbit portal vein smooth muscle

1997 • 49 citations

Protein kinase a-mediated phosphorylation reduces only the fast desensitizing glycine current in acutely dissociated ventromedial hypothalamic neurons

1993 • 43 citations

Structure, diversity and synaptic localization of inhibitory glycine receptors

1994 • 43 citations

Physiology and pharmacology of native glycine receptors in developing rat auditory brainstem neurons

1997 • 42 citations

Involvement of phosphatase activities in the run-down of GABAA receptor function in rat cerebellar granule cells in culture

1998 • 37 citations

Glycine current in rat septal cholinergic neuron in culture: monophasic positive modulation by Zn2+

1996 • 37 citations

Inhibition of GABAAReceptor Function by Tyrosine Kinase Inhibitors and Their Inactive Analogues

1998 • 33 citations

Influence of subunit configuration on the interaction of picrotoxin-site ligands with recombinant GABAA receptors

2000 • 32 citations