Neurosteroids: Beginning of the story

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

GABA_A Receptor Channels

1994 • 1,948 citations

Neuroactive steroids

1992 • 1,260 citations

Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance

1992 • 1,098 citations

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

1991 • 943 citations

Non-genomic and genomic effects of steroids on neural activity

1991 • 731 citations

Intracrinology

1991 • 654 citations

Characterization and measurement of dehydroepiandrosterone sulfate in rat brain.

1981 • 645 citations

The Biological Synthesis of Cholesterol

1965 • 524 citations

A corticosteroid Receptor in Neuronal Membranes

1991 • 522 citations

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

1991 • 521 citations

Neurosteroids act on recombinant human GABAA receptors

1990 • 515 citations

Modulation of the GABA receptor complex by a steroid anaesthetic

1984 • 496 citations

Progesterone Synthesis and Myelin Formation by Schwann Cells

1995 • 471 citations

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

1992 • 442 citations

The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor

1990 • 433 citations

Neurosteroidogenesis in Astrocytes, Oligodendrocytes, and Neurons of Cerebral Cortex of Rat Brain

1999 • 432 citations

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.

1995 • 426 citations

Peripheral-Type Benzodiazepine/Diazepam Binding Inhibitor Receptor: Biological Role in Steroidogenic Cell Function*

1993 • 404 citations

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain

1993 • 402 citations

Pregnenolone and its sulfate ester in the rat brain

1983 • 382 citations

Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions.

1992 • 375 citations

Neurosteroids: Biosynthesis of Pregnenolone and Progesterone in Primary Cultures of Rat Glial Cells*

1989 • 372 citations

Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system.

1999 • 366 citations

Neurosteroids: Cytochrome P-450 _scc in Rat Brain

1987 • 362 citations

Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats.

1993 • 344 citations

Neurosteroids

1994 • 310 citations

Neurosteroids: Deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus

1997 • 299 citations

Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.

1987 • 294 citations

Progesterone modulates a neuronal nicotinic acetylcholine receptor.

1992 • 272 citations

Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons

1988 • 271 citations

Steroid-induced meiotic division in Xenopus laevis oocytes: surface and calcium

1978 • 268 citations

Emerging diversities in the mechanism of action of steroid hormones

1995 • 265 citations

Progestin receptor levels in rat hypothalamic and limbic nuclei

1982 • 251 citations

Steroid Hormone Regulation of the Brain

1981 • 228 citations

Behavioral Effects of Progesterone Associated with Rapid Modulation of Oxytocin Receptors

1990 • 223 citations

Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7α-hydroxy dehydroepiandrosterone and 7α-hydroxy pregnenolone

1997 • 219 citations

Progesterone inhibits membrane-bound adenylate cyclase in Xenopus laevis oocytes

1981 • 218 citations

Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat

1993 • 214 citations

A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), is expressed in rat brain

1995 • 207 citations

STEROID HORMONES IN THE BRAIN: SEVERAL MECHANISMS?

1981 • 199 citations

Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.

1995 • 191 citations

AN ADRENAL-SECRETED "ANDROGEN": DEHYDROISOANDROSTERONE SULFATE. ITS METABOLISM AND A TENTATIVE GENERALIZATION ON THE METABOLISM OF OTHER STEROID CONJUGATES IN MAN.

1965 • 184 citations

Sex steroids and 5-en-3β-hydroxysteroids in specific regions of the human brain and cranial nerves

1986 • 184 citations

Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency

1989 • 184 citations

Biology and Genetics of Hereditary Motor and Sensory Neuropathies

1995 • 179 citations

Dehydroepiandrosterone: Biosynthesis and Metabolism in the Brain

1999 • 177 citations

Progesterone Stimulates the Activity of the Promoters of Peripheral Myelin Protein‐22 and Protein Zero Genes in Schwann Cells

1998 • 176 citations

Olfaction in humans with special reference to odorous 16-androstenes: their occurrence, perception and possible social, psychological and sexual impact

1993 • 175 citations

Neuro-steroids: 3β-hydroxy-δ5-derivatives in rat and monkey brain

1987 • 174 citations

Neurosteroid metabolism. 7α-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes

1992 • 165 citations

Messenger RNAs encoding steroidogenic enzymes are expressed in rodent brain

1995 • 165 citations

Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density.

1993 • 164 citations

Validation of an analytical procedure to measure trace amounts of neurosteroids in brain tissue by gas chromatography–mass spectrometry

2000 • 159 citations

Progesterone in uterus and plasma. IV — Progesterone receptor(s) in guinea pig uterus cytosol

1970 • 157 citations

A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons.

1995 • 157 citations

Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.

1995 • 149 citations

Aromatase in the Cerebral Cortex, Hippocampus, and Mid-Brain: Ontogeny and Developmental Implications

1994 • 148 citations

Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism

1994 • 147 citations

Differential localization of the 5 alpha-reductase and the 3 alpha-hydroxysteroid dehydrogenase in neuronal and glial cultures.

1993 • 143 citations

STUDIES ON THE SECRETION AND INTERCONVERSION OF THE ANDROGENS.

1963 • 143 citations

Neurosteroidogenesis in Astrocytes, Oligodendrocytes, and Neurons of Cerebral Cortex of Rat Brain

1999 • 139 citations

Simultaneous radioimmunoassay of progesterone, androst-4-enedione, pregnenolone, dehydroepiandrosterone and 17-hydroxyprogesterone in specific regions of human brain

1987 • 134 citations

Origin of cholesterol in myelin

1996 • 134 citations

Expression of Cytochrome P450 Side‐Chain Cleavage Enzyme and 3β‐Hydroxysteroid Dehydrogenase in the Rat Central Nervous System: A Study by Polymerase Chain Reaction and In Situ Hybridization

1995 • 132 citations

Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly

2000 • 130 citations

The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task

1994 • 126 citations

Demonstration of progesterone receptors in rat Schwann cells

1996 • 125 citations

Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse

2000 • 124 citations

Pregnenolone, dehydroepiandrosterone, and their sulfate and fatty acid esters in the rat brain

1989 • 120 citations

The Regulation of Intracellular Transport of Cholesterol in Bovine Adrenal Cells: Purification of a Novel Protein

1988 • 115 citations

In vitro studies on the role of the peripheral-type benzodiazepine receptor in steroidogenesis

1999 • 114 citations

Sex steroid effects on extrahypothalamic CNS. I. Estrogen augments neuronal responsiveness to iontophoretically applied glutamate in the cerebellum

1987 • 111 citations

Neurosteroids A New Regulatory Function in the Nervous System

2000 • 110 citations

Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis

1999 • 110 citations

Neurosteroidogenesis in Rat Retinas

1994 • 109 citations

A specific membrane binding protein for progesterone in rat brain: sex differences and induction by estrogen.

1993 • 107 citations

Neurosteroid biosynthesis in vertebrate brains

1999 • 105 citations

Progesterone 5-α-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes

1994 • 104 citations

Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats

1993 • 104 citations

Estrogen-inducible progesterone receptor in primary cultures of rat glial cells

1991 • 102 citations

Neurosteroid modulation of native and recombinant GABAA receptors

1996 • 96 citations

Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system

1995 • 96 citations

Structure and tissue-specific expression of 3ß-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues

1992 • 88 citations

Neuro-steroids: 3β-hydroxy-Δ5-derivatives in the rodent brain

1985 • 86 citations

Neurosteroids and Brain Function

2001 • 81 citations

Neurosteroids: Expression of Functional 3β‐Hydroxysteroid Dehydrogenase by Rat Sensory Neurons and Schwann Cells

1997 • 78 citations

Hydroxysteroid sulfotransferase activity in the rat brain and liver as a function of age and sex

1997 • 75 citations

Dehydroepiandrosterone: Biosynthesis and Metabolism in the Brain

1999 • 73 citations

Immunocytochemical Localization of 5α-Reductase in Rat Brain

1994 • 73 citations

Neurosteroids: pregnenolone in human sciatic nerves.

1992 • 72 citations

Detection in bovine adrenal cortex of a lipoidal substance that yields pregnenolone upon treatment with alkali.

1977 • 71 citations

Ontogeny of 5 alpha-reductase (type 1) messenger ribonucleic acid expression in rat brain: early presence in germinal zones.

1996 • 69 citations

Genomic and membrane actions of progesterone: implications for reproductive physiology and behavior

1999 • 69 citations

Differential localization of the 5 alpha-reductase and the 3 alpha- hydroxysteroid dehydrogenase in neuronal and glial cultures

1993 • 68 citations

Suppressive effects of dehydroepiandrosterone and 3β-methyl-androst-5-en-17-one on attack towards lactating female intruders by castrated male mice. II. Brain neurosteroids

1991 • 68 citations

Cytochrome P450 in the Brain: Neuroendocrine Functions

1995 • 67 citations

Pregnenolone sulfate antagonizes barbiturate-induced hypnosis

1989 • 65 citations

Corticosteroid synthesis in the central nervous system

1996 • 63 citations

Desensitization and noncompetitive blockade of GABA_A receptors in ventral midbrain neurons by a neurosteroid dehydroepiandrosterone sulfate

1994 • 61 citations

The oxytocin receptor: a target for steroid hormones

1993 • 60 citations

Steroids and neuronal activity

1992 • 55 citations

Precursors of the neurosteroids.

1994 • 55 citations

Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: implications for regulation of neurosteroidogenesis.

1995 • 52 citations

Steroid modulation of the strychnine-sensitive glycine receptor

1992 • 49 citations

Studies of the immunohistochemical and biochemical localization of the cytochrome P-450scc-linked monooxygenase system in the adult rat brain

1990 • 46 citations

Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis

1995 • 46 citations

The Cholesterol Side‐Chain Cleavage Complex in Human Brain White Matter

1989 • 43 citations

Anesthetic Effect of Steroid Hormones

1941 • 41 citations

Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice

2000 • 39 citations

Control of Cholesterol Biosynthesis in Schwann Cells

1998 • 39 citations

The presence of an adrenodoxin-like ferredoxin and cytochrome P-450 in brain mitochondria.

1979 • 38 citations

Neurosteroids: Regulatory mechanisms in male rat brain during heterosexual exposure

1985 • 38 citations

Symptoms Related to the Menopause and Sex Steroid Treatments

2007 • 38 citations

Non-reproductive actions of sex steroids

1996 • 37 citations

Neurosteroids: Steroidogenesis in primary cultures of rat glial cells after release of aminoglutethimide blockade

1989 • 37 citations

Suppressive effects of dehydroepiandrosterone and 3-β-methylandrost-5-en-17-one on attack towards lactating female intruders by castrated male mice

1989 • 34 citations

Low density lipoprotein-receptors in primary cultures of rat glial cells

1992 • 34 citations

Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: implications for regulation of neurosteroidogenesis

1995 • 32 citations

Ontogeny of 5 alpha-reductase (type 1) messenger ribonucleic acid expression in rat brain: early presence in germinal zones

1996 • 31 citations

Non-reproductive actions of sex steroids

1995 • 29 citations

Δ5-3β-Hydroxysteroid acyl transferase activity in the rat brain

1992 • 25 citations

A localization study of the cytochrome P-45021-linked monooxygenase system in adult rat brain

1993 • 23 citations

[Persistence of the circadian rhythm of dehydroepiandrosterone in the brain, but not in the plasma, of castrated and adrenalectomized rats].

1986 • 19 citations

Cytochrome P-45011? rat brain

1991 • 18 citations

“Prolegomena” to the biology of the diazepam binding inhibitor (DBI)

1991 • 13 citations

Aromatization and 19-hydroxylation of androgens by rat brain cytochrome P-450

1988 • 11 citations

Effects of hypothydroidism on the gene expression of progesterone receptors in the neonatal rat brain

1994 • 7 citations

Precursors of the neurosteroids

1994 • 5 citations

Deleted Work

1955 • 0 citations